| Title: |
Factors associated with early catheterization in patients randomized to the conservative strategy in the ISCHEMIA Trial |
| Authors: |
Pracon, R; Spertus, J A; Broderick, S; Bangalore, S; Rockhold, F W; Ruzyllo, W; Demchenko, E; Mavromatis, K; Stone, G W; Mancini, G B J; Boden, W E; Newman, J D; Reynolds, H R; Hochman, J S; Maron, D M |
| Source: |
European Heart Journal ; volume 43, issue Supplement_2 ; ISSN 0195-668X 1522-9645 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2022 |
| Description: |
Background In the ISCHEMIA trial, individuals randomized to the conservative strategy (CON) could undergo coronary catheterization (cath) for suspicion of an endpoint event, persistent symptoms despite optimal medical therapy, or through protocol non-adherence. Understanding the reasons for cath in CON participants can aid in ISCHEMIA results interpretation. Purpose To describe the frequency of and factors associated with early cath in ISCHEMIA CON participants. Methods A prespecified, post-hoc analysis of the 2591 CON participants was performed with multivariable analyses to identify independent factors associated with cath within 6 months of randomization (“early cath”). Results Overall 8.7% (225/2591) of CON participants underwent an early cath: with 4.6% (119/2591) for a suspected endpoint, 1.6% (41/2591) for medical treatment failure, and 2.6% (67/2591) for protocol non-adherence; 67% of all these caths (151/225) occurred within the first 3 months from randomization. Independent factors associated with cath among CON participants included daily (HR=5.84, CI: 2.73–12.47, p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/eurheartj/ehac544.1215 |
| Availability: |
https://doi.org/10.1093/eurheartj/ehac544.1215; https://academic.oup.com/eurheartj/article-pdf/43/Supplement_2/ehac544.1215/46362103/ehac544.1215.pdf |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.96D0173D |
| Database: |
BASE |