| Title: |
Clinical presentation, disease course, and outcome of COVID-19 in hospitalized patients with and without pre-existing cardiac disease: a cohort study across 18 countries |
| Authors: |
Linschoten, M; Uijl, A; Schut, A; Jakob, CEM; Romao, LR; Bell, RM; McFarlane, E; Stecher, M; Zondag, AGM; van Iperen, EPA; Hermans-van Ast, JF; Lea, NC; Schaap, J; Jewbali, LS; Smits, PC; Patel, RS; Aujayeb, A; van Smeden, M; Siebelink, HJ; Williams, S; Pilgram, L; Tieleman, RG; Williams, B; Asselbergs, FW; Al-Ali, AK; Al-Muhanna, FA; Al-Rubaish, AM; Al-Windy, NYY; Alkhalil, M; Almubarak, YA; Al Nafie, AN; Al Shahrani, M; Al Shehri, AM; Anning, C; Anthonio, RL; Badings, EA; Ball, C; Van Beek, EA; Ten Berg, JM; Von Bergwelt-Baildon, M; Bianco, M; Blagova, O; Bleijendaal, H; Bor, WL; Borgmann, S; van Boxem, AJM; van den Brink, FS; Bucciarelli-Ducci, C; Van Bussel, BCT; Byrom-Goulthorp, R; Captur, G; Caputo, M; Charlotte, N; vom Dahl, J; Dark, P; De Sutter, J; Degenhardt, C; Delsing, CE; Dolff, S; Dorman, HGR; Drost, JT; Eberwein, L; Emans, ME; Er, AG; Ferreira, JB; Forner, MJ; Friedrichs, A; Gabriel, L; Groenemeijer, BE; Groenendijk, AL; Gruener, B; Guggemos, W; Haerkens-Arends, HE; Hanses, F; Hedayat, B; Heigener, D; van der Heijden, DJ; Hellou, E; Hellwig, K; Henkens, MTHM; Hermanides, RS; Hermans, WRM; van Hessen, MWJ; Heymans, SRB; Hilt, AD; van der Horst, ICC; Hower, M; van Ierssel, SH; Isberner, N; Jensen, B; Kearney, MT; Kielstein, JT; Kietselaer, BLJH; Kochanek, M; Kolk, MZH; Koning, AMH; Kopylov, PY; Kuijper, AFM; Kwakkel-van, ERPJM; Lanznaster, J; van der Linden, MMJM; van der Lingen, ACJ; Linssen, GCM; Lomas, D; Maarse, M; Magdelijns, FJH; Magro, M; Markart, P; Martens, FMAC; Mazzilli, SG; McCann, GP; van der Meer, P; Meijs, MFL; Merle, U; Messiaen, P; Milovanovic, M; Monraats, PS; Montagna, L; Moriarty, A; Moss, AJ; Mosterd, A; Nadalin, S; Nattermann, J; Neufang, M; Nierop, PR; Offerhaus, JA; Van Ofwegen-Hanekamp, CEE; Parker, E; Persoon, AM; Piepel, C; Pinto, YM; Poorhosseini, H; Prasad, S; Raafs, AG; Raichle, C; Rauschning, D; Redon, J; Reidinga, AC; Ribeiro, MIA; Riedel, C; Rieg, S; Ripley, DP; Rommele, C; Rothfuss, K; Ruddel, J; Ruthrich, MM; Salah, R; Saneei, E; Saxena, M; Schellings, DAAM; Scholte, NTB; Schubert, J; Seelig, J; Shafiee, A; Shore, AC; Spinner, C; Stieglitz, S; Strauss, R; Sturkenboom, NH; Tessitore, E; Thomson, RJ; Timmermans, PJR; Tio, RA; Tjong, FVY; Tometten, L; Trauth, J; Van Craenenbroeck, EM; van Veen, HPAA; den Uil, CA; Vehreschild, MJGT; Veldhuis, L; Veneman, T; Verschure, DO; Voigt, I; Walter, L; vande Watering, DJ; de Vries, JK; vande Wal, RMA; Westendorp, ICD; Westendorp, PHM; Westhoff, T; Weytjens, C; Wierda, E; Wille, K; de With, K; Worm, M; Woudstra, P; Wu, KW; Zaal, R; Zaman, AG; van der Zee, PM; Zijlstra, LE; Alling, TE; Ahmed, R; Bayraktar-Verver, ECE; van Aken, K; Jimenes, Bermudez FJ; Biole, CA; Den Boer-Penning, P; Bontje, M; Bos, M; Bosch, L; Broekman, M; Broeyer, FJF; de Bruijn, EAW; Bruinsma, S; Cardoso, NM; Cosyns, B; Len, van Da DH; Dekimpe, E; Domange, J; van Doorn, JL; van DOorn, P; Dormal, F; Drost, IMJ; Dunnink, A; van Eck, JWM; Elshinawy, K; Gevers, RMM; Gognieva, DG; van der Graaf, M; Grangeon, S; Guclu, A; Habib, A; Haenen, NA; Hamilton, K; Handgraaf, S; Heidbuchel, H; Hendriks-van Woerden, M; Hessels-Linnemeijer, BM; Hosseini, K; Huisman, J; Jacobs, TC; Jansen, SE; Janssen, A; Jourdan, K; ten Kate, GL; van Kempen, MJ; Kievit, CM; Kleikers, P; Knufman, N; van der Kooi, SE; Koole, BAS; Koole, MAC; Kui, KK; Kuipers-Elferink, L; Lemoine, I; Lensink, E; van Marrewijk, V; Meijer, EJ; Melein, AJ; Mesitskaya, DF; van Nes, CPM; Paris, FMA; Perrelli, MG; Pieterse-Rots, A; Pisters, R; Polkerman, BC; van Poppel, A; Reinders, S; Reitsma, MJ; Ruiter, AH; Selder, JL; van der Sluis, A; Sousa, AIC; Tajdini, M; Sanchez, Tercedor L; Van de Heyning, CM; Vial, H; Vlieghe, E; Vonkeman, HE; Vreugdenhil, P; de Vries, TAC; Willems, AM; Wils, AM; Zoet-Nugteren, SK |
| Source: |
European Heart Journal , 43 (11) pp. 1104-1120. (2022) |
| Publisher Information: |
OXFORD UNIV PRESS |
| Publication Year: |
2022 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
Science & Technology; Life Sciences & Biomedicine; Cardiac & Cardiovascular Systems; Cardiovascular System & Cardiology; COVID-19; SARS-CoV-2; Epidemiology; Patient registry; Comorbidity; Cardiovascular disease; HEART-FAILURE; AMERICAN-COLLEGE; EUROPEAN-SOCIETY; TASK-FORCE; ASSOCIATION; GUIDELINES; MANAGEMENT; DIAGNOSIS |
| Description: |
AIMS: Patients with cardiac disease are considered high risk for poor outcomes following hospitalization with COVID-19. The primary aim of this study was to evaluate heterogeneity in associations between various heart disease subtypes and in-hospital mortality. METHODS AND RESULTS: We used data from the CAPACITY-COVID registry and LEOSS study. Multivariable Poisson regression models were fitted to assess the association between different types of pre-existing heart disease and in-hospital mortality. A total of 16 511 patients with COVID-19 were included (21.1% aged 66-75 years; 40.2% female) and 31.5% had a history of heart disease. Patients with heart disease were older, predominantly male, and often had other comorbid conditions when compared with those without. Mortality was higher in patients with cardiac disease (29.7%; n = 1545 vs. 15.9%; n = 1797). However, following multivariable adjustment, this difference was not significant [adjusted risk ratio (aRR) 1.08, 95% confidence interval (CI) 1.02-1.15; P = 0.12 (corrected for multiple testing)]. Associations with in-hospital mortality by heart disease subtypes differed considerably, with the strongest association for heart failure (aRR 1.19, 95% CI 1.10-1.30; P < 0.018) particularly for severe (New York Heart Association class III/IV) heart failure (aRR 1.41, 95% CI 1.20-1.64; P < 0.018). None of the other heart disease subtypes, including ischaemic heart disease, remained significant after multivariable adjustment. Serious cardiac complications were diagnosed in |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10146390/3/Patel_Manuscript_23082021_PL.pdf; https://discovery.ucl.ac.uk/id/eprint/10146390/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10146390/3/Patel_Manuscript_23082021_PL.pdf; https://discovery.ucl.ac.uk/id/eprint/10146390/ |
| Rights: |
open |
| Accession Number: |
edsbas.96EE9802 |
| Database: |
BASE |