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Beyond the Numbers: Reframing Uric Acid Elevations in Bempedoic Acid Therapy

Title: Beyond the Numbers: Reframing Uric Acid Elevations in Bempedoic Acid Therapy
Authors: Fogacci F; Borghi C; Cicero AFG
Contributors: Fogacci, F; Borghi, C; Cicero, Arrigo Francesco Giuseppe
Publication Year: 2025
Collection: IRIS Università degli Studi di Bologna (CRIS - Current Research Information System)
Subject Terms: Uric acid; bempedoic acid; xanthine oxidase
Description: We read with great interest the brief report by Prof. Ray et al on the association between uric acid– lowering therapies and gout incidence among patients treated with bempedoic acid in the CLEAR (Cholesterol LowEring via bempedoic acid, an ACLinhibiting Regimen) Outcomes trial.1 The authors are to be commended for addressing an often-overlooked metabolic aspect of bempedoic acid therapy and for providing valuable insights into the management of hyperuricemia in this population. We would like to offer a few considerations that may further contextualize and expand the clinical interpretation of these findings
Document Type: article in journal/newspaper
File Description: ELETTRONICO
Language: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/41421014; info:eu-repo/semantics/altIdentifier/wos/WOS:001650533800002; volume:5; issue:1; firstpage:1; lastpage:2; numberofpages:2; journal:JACC. ADVANCES; https://hdl.handle.net/11585/1050377; https://www.sciencedirect.com/science/article/pii/S2772963X25009111
DOI: 10.1016/j.jacadv.2025.102482
Availability: https://hdl.handle.net/11585/1050377; https://doi.org/10.1016/j.jacadv.2025.102482; https://www.sciencedirect.com/science/article/pii/S2772963X25009111
Rights: info:eu-repo/semantics/openAccess ; license:Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY) ; license uri:iris.PUB15
Accession Number: edsbas.96F20EB7
Database: BASE