| Title: |
Direct virucidal effect of a throat lozenge with fixed combination of cetylpyridinium chloride and benzydamine hydrochloride on SARS-CoV-2 – in vitro study |
| Authors: |
Codrut Sarafoleanu; Raluca Enache |
| Source: |
Romanian Journal of Pharmaceutical Practice, Vol 14, Iss 3-4, Pp 123-129 (2021) |
| Publisher Information: |
Amaltea Medical Publishing House |
| Publication Year: |
2021 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
sars-cov-2; cetylpyridinium chloride; benzydamine hydrochloride; lozenge; respiratory tract infection; Therapeutics. Pharmacology; RM1-950; Pharmacy and materia medica; RS1-441 |
| Description: |
Objectives. To evaluate the in vitro virucidal effect of the combination of cetylpyridinium chloride (CPC) and benzydamine hydrochloride (BH) as a throat lozenge against the novel SARS-CoV-2. Material and methods. The study evaluated the viral presence and titre in cell cultures by using SARS-CoV-2 virus incubated for 1, 5, 15 minutes, with three different concentrations of three different active substances (CPC, free BH/ CPC, BH/CPC lozenge). The titre of the virus was expressed as TCID50/ml calculated with the Spearman-Kärber method. Outcomes. The faster virucidal effect in high concentration was seen in the combination BH/CPC as throat lozenge when compared to CPC as free active substance. A reduction of the virus concentration was seen, at 15 minutes contact, in all three concentrations. Conclusions. There is a strong virucidal effect a throat lozenge with fixed combination of cetylpyridinium chloride and benzydamine hydrochloride on the novel coronavirus. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://farma.com.ro/articles/2021.3-4/RJPhP_2021_3-4_Art-04.pdf; https://doaj.org/toc/2066-5563; https://doaj.org/toc/2069-6671; https://doaj.org/article/0e50ef00a14d422c8a3e4ad4fa5b97bf |
| DOI: |
10.37897/RJPhP.2021.3.3 |
| Availability: |
https://doi.org/10.37897/RJPhP.2021.3.3; https://doaj.org/article/0e50ef00a14d422c8a3e4ad4fa5b97bf |
| Accession Number: |
edsbas.971BCA5F |
| Database: |
BASE |