| Title: |
Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19 |
| Authors: |
Mann, ER; Menon, M; Knight, SB; Konkel, JE; Jagger, C; Shaw, TN; Krishnan, S; Rattray, M; Ustianowski, A; Bakerly, ND; Dark, P; Lord, G; Simpson, A; Felton, T; Ho, L-P; NIHR Respiratory TRC, .; Feldmann, M; CIRCO, .; Grainger, JR; Hussell, T |
| Source: |
Science Immunology , 5 (51) , Article eabd6197. (2020) |
| Publication Year: |
2020 |
| Collection: |
University College London: UCL Discovery |
| Description: |
COVID-19 pathogenesis is associated with an exaggerated immune response. However, the specific cellular mediators and inflammatory components driving diverse clinical disease outcomes remain poorly understood. We undertook longitudinal immune profiling on both whole blood and peripheral blood mononuclear cells of hospitalized patients during the peak of the COVID-19 pandemic in the United Kingdom. Here, we report key immune signatures present shortly after hospital admission that were associated with the severity of COVID-19. Immune signatures were related to shifts in neutrophil to T cell ratio, elevated serum IL-6, MCP-1, and IP-10 and modulation of CD14+ monocyte phenotype and function. Modified features of CD14+ monocytes included poor induction of the prostaglandin-producing enzyme, COX-2, and enhanced expression of the cell cycle marker Ki-67. Longitudinal analysis revealed reversion of some immune features back to the healthy median level in patients with a good eventual outcome. These findings identify previously unappreciated alterations in the innate immune compartment of patients with COVID-19 and lend support to the idea that therapeutic strategies targeting release of myeloid cells from bone marrow should be considered in this disease. Moreover, they demonstrate that features of an exaggerated immune response are present early after hospital admission, suggesting that immunomodulating therapies would be most beneficial at early time points. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10111413/1/eabd6197.full.pdf; https://discovery.ucl.ac.uk/id/eprint/10111413/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10111413/1/eabd6197.full.pdf; https://discovery.ucl.ac.uk/id/eprint/10111413/ |
| Rights: |
open |
| Accession Number: |
edsbas.9746E2FC |
| Database: |
BASE |