| Title: |
Sex Differences in Longitudinal Tau-PET in Preclinical Alzheimer Disease : A Meta-Analysis |
| Authors: |
Coughlan, Gillian T.; Klinger, Hannah M.; Boyle, Rory; Betthauser, Tobey J.; Binette, Alexa Pichet; Christenson, Luke; Chadwick, Trevor; Hansson, Oskar; Harrison, Theresa M.; Healy, Brian; Jacobs, Heidi I. L.; Hanseeuw, Bernard; Jonaitis, Erin; Jack, Clifford R.; Johnson, Keith A.; Langhough, Rebecca E.; Properzi, Michael J.; Rentz, Dorene M.; Schultz, Aaron P.; Smith, Ruben; Seto, Mabel; Johnson, Sterling C.; Mielke, Michelle M.; Shirzadi, Zahra; Yau, Wai-Ying Wendy; Manson, JoAnn E.; Sperling, Reisa A.; Vemuri, Prashanthi; Buckley, Rachel F.; Hurko, Orest; Black, Sanra E; Doody, Rachelle; Doraiswamy, Murali; Gamst, Anthony; Kaye, Jeffrey; Obisesan, Thomas; Rusinek, Henry; Scharre, Doug; Sperling, Reisa; Weiner, Michael W; Green., Robert C |
| Contributors: |
UCL - SSS/IONS/NEUR - Clinical Neuroscience |
| Source: |
JAMA Neurology, Vol. 82, no.4, p. 364 (2025) |
| Publisher Information: |
American Medical Association (AMA) |
| Publication Year: |
2025 |
| Collection: |
DIAL@USL-B (Université Saint-Louis, Bruxelles) |
| Description: |
Importance: Alzheimer disease (AD) predominates in females at almost twice the rate relative to males. Mounting evidence in adults without AD indicates that females exhibit higher tau deposition than age-matched males, particularly in the setting of elevated β-amyloid (Aβ), but the evidence for sex differences in tau accumulation rates is inconclusive. Objective: To examine whether female sex is associated with faster tau accumulation in the setting of high Aβ (as measured with positron emission tomography [PET]) and the moderating influence of sex on the association between APOEε4 carrier status and tau accumulation. Data sources: This meta-analysis used data from 6 longitudinal aging and AD studies, including the Alzheimer's Disease Neuroimaging Initiative, Berkeley Aging Cohort Study, BioFINDER 1, Harvard Aging Brain Study, Mayo Clinic Study of Aging, and Wisconsin Registry for Alzheimer Prevention. Longitudinal data were collected between November 2004 and May 2022. Study selection: Included studies required available longitudinal [18F]flortaucipir or [18F]-MK-6240 tau-PET scans, as well as baseline [11C] Pittsburgh Compound B, [18F]flutemetamol or [18F]florbetapir Aβ-PET scans. Recruitment criteria varied across studies. Analyses began on August 7, 2023, and were completed on February 5, 2024. Data extraction and synthesis: In each study, primary analyses extracted estimates for the sex (female or male) and the sex by baseline Aβ-PET status (high or low) association with longitudinal tau-PET using a series of mixed-effects models. Secondary mixed-effects models extracted the interaction estimate for the association of sex by APOEε4 carrier status with longitudinal tau-PET. Study-specific estimates for each mixed-effects model were then pooled in a meta-analysis, and the global fixed effect (β) and total heterogeneity (I2) across studies were estimated. This study is reported following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline. Main outcomes and ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
boreal:303504; http://hdl.handle.net/2078.1/303504 |
| DOI: |
10.1001/jamaneurol.2025.0013 |
| Availability: |
http://hdl.handle.net/2078.1/303504; https://doi.org/10.1001/jamaneurol.2025.0013 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.977310A7 |
| Database: |
BASE |