| Title: |
Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission |
| Authors: |
F. Nicoletti; G. Battaglia; R. Di Marco; D. Melchiorri; V. Bruno; M. Storto; Richard Ngomba; L. Iacovelli; A. Arcella; R. Gradini; P. Sale; L. Rampello; T. De Vita |
| Publication Year: |
2007 |
| Subject Terms: |
B140 - Neuroscience; B210 - Pharmacology; Animals; antigen presenting cell; article; brain tumor; central nervous system; G protein coupled receptor; gene expression; glioblastoma; glutamate receptor 1; glutamate receptor 3; glutamate receptor 4; Glutamic Acid; Hepatocytes; human; human cell; Humans; melanoma; Metabotropic Glutamate; metabotropic receptor; Neoplastic Stem Cells; neural stem cell; neurotransmission; Osteoblasts; Pancreas; pathophysiology; priority journal; receptor gene; receptor subtype |
| Description: |
Metabotropic glutamate (mGlu) receptors are G-protein coupled receptors activated by glutamate, the major excitatory neurotransmitter of the CNS. A growing body of evidence suggests that the function of mGlu receptors is not restricted to the regulation of synaptic transmission. mGlu receptors are expressed in a variety of peripheral cells, including inter alia hepatocytes, pancreatic cells, osteoblasts and immune cells. Within the immunological synapses, mGlu receptors expressed by T cells might contribute to the vast array of signals generated by the antigen-presenting cells. mGlu receptors are also found in embryonic and neural stem cells. This suggests their involvement in the pathophysiology of brain tumors, which likely originates from cancer stem cells similar to neural stem cells. Ligands of mGlu3 and mGlu4 receptors are potential candidates for the experimental treatment of malignant gliomas and medulloblastomas, respectively. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
10779/lincoln.24345790.v2; https://figshare.com/articles/journal_contribution/Metabotropic_glutamate_receptors_Beyond_the_regulation_of_synaptic_transmission/24345790 |
| Availability: |
https://figshare.com/articles/journal_contribution/Metabotropic_glutamate_receptors_Beyond_the_regulation_of_synaptic_transmission/24345790 |
| Rights: |
CC BY 4.0 |
| Accession Number: |
edsbas.97A738CC |
| Database: |
BASE |