| Title: |
Multi-scale signaling and tumor evolution in high-grade gliomas |
| Authors: |
Liu, Jingxian; Cao, Song; Imbach, Kathleen; Gritsenko, Maarina A.; Lih, Tung-Shing M.; Kyle, Jennifer E.; Yaron-Barir, Tomer M.; Binder, Zev A.; Li, Yize; Strunilin, Ilya; Wang, Yi-Ting; Tsai, Chia-Feng; Ma, Weiping; Chen, Lijun; Clark, Natalie M.; Shinkle, Andrew; Naser Al Deen, Nataly; Caravan, Wagma; Houston, Andrew; Simin, Faria Anjum; Wyczalkowski, Matthew A.; Wang, Liang-Bo; Storrs, Erik; Chen, Siqi; Illindala, Ritvik; Li, uping D.; Jayasinghe, Reyka; Rykunov, Dmitry; Cottingham, Sandra L.; Chu, Rosalie K.; Weitz, Karl K.; Moore, Ronald J.; Sagendorf, Tyler; Petyuk, Vladislav A.; Nestor, Michael; Bramer, Lisa M.; Stratton, Kelly G.; Schepmoes, Athena A.; Couvillion, Sneha P.; Eder, Josie; Kim, Young-Mo; Gao, Yuqian; Fillmore, Thomas L.; Zhao, Rui; Monroe, Matthew E.; Southard-Smith, Austin N.; Li, Yang E.; Jui-Hsien Lu, Rita; Johnson, Jared L.; Wiznerowicz, Maciej; Hostetter, Galen; Newton, Chelsea J.; Ketchum, Karen A.; Thangudu, Ratna R.; Barnholtz-Sloan, Jill S.; Wang, Pei; Fenyö, David; An, Eunkyung; Thiagarajan, Mathangi; Robles, Ana I.; Mani, D.R.; Smith, Richarf D.; Porta-Pardo, Eduard; Cantley, Lewis C.; Iavarone, Antonio; Chen, Feng; Mesri, Mehdi; Nasrallah, MacLean P.; Zhang, Hui; Resnick, Adam C.; Chheda, Milan G.; Rodland, Karin D.; Liu, Tao; Ding, Li; Universitat Autònoma de Barcelona |
| Publication Year: |
2024 |
| Collection: |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| Subject Terms: |
CPTAC; Glioblastoma; Glycoproteomics; Lipidome; Metabolome; Proteomics; Single nuclei ATAC-seq; Single nuclei RNA-seq; Tumor recurrence |
| Description: |
Although genomic anomalies in glioblastoma (GBM) have been well studied for over a decade, its 5-year survival rate remains lower than 5%. We seek to expand the molecular landscape of high-grade glioma, composed of IDH-wildtype GBM and IDH-mutant grade 4 astrocytoma, by integrating proteomic, metabolomic, lipidomic, and post-translational modifications (PTMs) with genomic and transcriptomic measurements to uncover multi-scale regulatory interactions governing tumor development and evolution. Applying 14 proteogenomic and metabolomic platforms to 228 tumors (212 GBM and 16 grade 4 IDH-mutant astrocytoma), including 28 at recurrence, plus 18 normal brain samples and 14 brain metastases as comparators, reveals heterogeneous upstream alterations converging on common downstream events at the proteomic and metabolomic levels and changes in protein-protein interactions and glycosylation site occupancy at recurrence. Recurrent genetic alterations and phosphorylation events on PTPN11 map to important regulatory domains in three dimensions, suggesting a central role for PTPN11 signaling across high-grade gliomas. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
85197092; 18783686 |
| Relation: |
Cancer Cell; Vol. 42 Núm. 7 (august 2024), p. 1217-1238.e19; https://ddd.uab.cat/record/309357; urn:10.1016/j.ccell.2024.06.004; urn:oai:ddd.uab.cat:309357; urn:scopus_id:85197092645; urn:articleid:18783686v42n7p1217; urn:pmid:38981438; urn:pmcid:PMC11337243; urn:oai:pubmedcentral.nih.gov:11337243 |
| Availability: |
https://ddd.uab.cat/record/309357 |
| Rights: |
open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. ; https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.97B59A69 |
| Database: |
BASE |