| Title: |
Higher systolic blood pressure in early-mid adulthood is associated with poorer cognitive performance in those with a dominantly inherited Alzheimer's disease mutation but not in non-carriers. Results from the DIAN study |
| Authors: |
Xu, Y; Aung, HL; Bateman, RJ; Brooks, WS; Chhatwal, J; Day, GS; Fagan, AM; Farlow, MR; Gordon, B; Kehoe, PG; Levin, J; Mori, H; Morris, JC; Wharton, W; Humburg, P; Schofield, PR; Peters, R |
| Source: |
urn:ISSN:1552-5260 ; urn:ISSN:1552-5279 ; Alzheimer S and Dementia, 19, 11, 4999-5009 |
| Publisher Information: |
Wiley |
| Publication Year: |
2023 |
| Collection: |
UNSW Sydney (The University of New South Wales): UNSWorks |
| Subject Terms: |
32 Biomedical and Clinical Sciences; 5202 Biological Psychology; 3202 Clinical Sciences; 3209 Neurosciences; 52 Psychology; Aging; Dementia; Genetics; Clinical Research; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Neurosciences; Acquired Cognitive Impairment; Neurodegenerative; Alzheimer's Disease; Brain Disorders; Behavioral and Social Science; Hypertension; Humans; Male; Adult; Female; Alzheimer Disease; Cross-Sectional Studies; Blood Pressure; Cognition; Mutation; autosomal-dominant Alzheimer's disease; Dominantly Inherited Alzheimer Network (DIAN); anzsrc-for: 32 Biomedical and Clinical Sciences; anzsrc-for: 5202 Biological Psychology |
| Description: |
BACKGROUND: The Dominantly Inherited Alzheimer Network (DIAN) is a longitudinal observational study that collects data on cognition, blood pressure (BP), and other variables from autosomal-dominant Alzheimer's disease mutation carriers (MCs) and non-carrier (NC) family members in early to mid-adulthood, providing a unique opportunity to evaluate BP and cognition relationships in these populations. METHOD: We examined cross-sectional and longitudinal relationships between systolic and diastolic BP and cognition in DIAN MC and NC. RESULTS: Data were available from 528 participants, who had a mean age of 38 (SD = 11) and were 42% male and 61% MCs, at a median follow-up of 2 years. Linear-multilevel models found only cross-sectional associations in the MC group between higher systolic BP and poorer performance on language (β = −0.181 [−0.318, −0.044]), episodic memory (−0.212 [−0.375, −0.049]), and a composite cognitive measure (−0.146 [−0.276, −0.015]). In NCs, the relationship was cross-sectional only and present for language alone. DISCUSSION: Higher systolic BP was cross-sectionally but not longitudinally associated with poorer cognition, particularly in MCs. BP may influence cognition gradually, but further longitudinal research is needed. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://hdl.handle.net/1959.4/unsworks_83601; https://doi.org/10.1002/alz.13082 |
| DOI: |
10.1002/alz.13082 |
| Availability: |
https://hdl.handle.net/1959.4/unsworks_83601; https://unsworks.unsw.edu.au/bitstreams/d5d9c57d-3195-470d-b173-1c844568039e/download; https://doi.org/10.1002/alz.13082 |
| Rights: |
open access ; https://purl.org/coar/access_right/c_abf2 ; CC BY ; https://creativecommons.org/licenses/by/4.0/ ; free_to_read |
| Accession Number: |
edsbas.97C7C717 |
| Database: |
BASE |