| Title: |
Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer |
| Authors: |
Barnes, Daniel R.; Tyrer, Jonathan P.; Dennis, Joe; Leslie, Goska; Bolla, Manjeet K.; Lush, Michael; Aeilts, Amber M.; Aittomäki, Kristiina; Andrieu, Nadine; Andrulis, Irene L.; Anton-Culver, Hoda; Arason, Adalgeir; Arun, Banu K.; Balmaña, Judith; Bandera, Elisa V.; Barkardottir, Rosa B.; Berger, Lieke P. V.; Berrington de Gonzalez, Amy; Berthet, Pascaline; Białkowska, Katarzyna; Bjørge, Line; Blanco, Amie M.; Blok, Marinus J.; Bobolis, Kristie A.; Bogdanova, Natalia V.; Brenton, James D.; Butz, Henriett; Buys, Saundra S.; Caligo, Maria A.; Campbell, Ian; Castillo, Carmen; Claes, Kathleen B. M.; Colonna, Sarah V.; Cook, Linda S.; Daly, Mary B.; Dansonka-Mieszkowska, Agnieszka; de la Hoya, Miguel; deFazio, Anna; DePersia, Allison; Ding, Yuan Chun; Doherty, Jennifer A.; Domchek, Susan M.; Dörk, Thilo; Einbeigi, Zakaria; Engel, Christoph; Evans, D. Gareth; Foretova, Lenka; Fortner, Renée T.; Fostira, Florentia; Foti, Maria Cristina; Friedman, Eitan; Frone, Megan N.; Ganz, Patricia A.; Gentry-Maharaj, Aleksandra; Glendon, Gord; Godwin, Andrew K.; González-Neira, Anna; Greene, Mark H.; Gronwald, Jacek; Guerrieri-Gonzaga, Aliana; Hamann, Ute; Hansen, Thomas V. O.; Harris, Holly R.; Hauke, Jan; Heitz, Florian; Hogervorst, Frans B. L.; Hooning, Maartje J.; Hopper, John L.; Huff, Chad D.; Huntsman, David G.; Imyanitov, Evgeny N.; Izatt, Louise; Jakubowska, Anna; James, Paul A.; Janavicius, Ramunas; John, Esther M.; Kar, Siddhartha; Karlan, Beth Y.; Kennedy, Catherine J.; Kiemeney, Lambertus A.L.M.; Konstantopoulou, Irene; Kupryjanczyk, Jolanta; Laitman, Yael; Lavie, Ofer; Lawrenson, Kate; Lester, Jenny; Lesueur, Fabienne; Lopez-Pleguezuelos, Carlos; Mai, Phuong L.; Manoukian, Siranoush; May, Taymaa; McNeish, Iain A.; Menon, Usha; Milne, Roger L.; Modugno, Francesmary; Mongiovi, Jennifer M.; Montagna, Marco; Moysich, Kirsten B.; Neuhausen, Susan L.; Nielsen, Finn C.; Noguès, Catherine; Oláh, Edit; Olopade, Olufunmilayo I.; Osorio, Ana; Papi, Laura; Pathak, Harsh; Pearce, Celeste L.; Pedersen, Inge S.; Peixoto, Ana; Pejovic, Tanja; Peng, Pei-Chen; Peshkin, Beth N.; Peterlongo, Paolo; Powell, C. Bethan; Prokofyeva, Darya; Pujana, Miquel Angel; Radice, Paolo; Rashid, Muhammad U.; Rennert, Gad; Richenberg, George; Sandler, Dale P.; Sasamoto, Naoko; Setiawan, Veronica W.; Sharma, Priyanka; Sieh, Weiva; Singer, Christian F.; Snape, Katie; Sokolenko, Anna P.; Soucy, Penny; Southey, Melissa C.; Stoppa-Lyonnet, Dominique; Sutphen, Rebecca; Sutter, Christian; Tan, Yen Y.; Teixeira, Manuel R.; Terry, Kathryn L.; Thomsen, Liv Cecilie V.; Tischkowitz, Marc; Toland, Amanda E.; Van Gorp, Toon; Vega, Ana; Velez Edwards, Digna R.; Webb, Penelope M.; Weitzel, Jeffrey N.; Wentzensen, Nicolas; Whittemore, Alice S.; Winham, Stacey J.; Wu, Anna H.; Yadav, Siddhartha; Yu, Yao; Ziogas, Argyrios; Berchuck, Andrew; Couch, Fergus J.; Goode, Ellen L.; Goodman, Marc T.; Monteiro, Alvaro N.; Offit, Kenneth; Ramus, Susan J.; Risch, Harvey A.; Schildkraut, Joellen M.; Thomassen, Mads; Simard, Jacques; Easton, Douglas F.; Jones, Michelle R.; Chenevix-Trench, Georgia; Gayther, Simon A.; Antoniou, Antonis C.; Pharoah, Paul D. P. |
| Contributors: |
Kristiina Aittomäki / Principal Investigator; HUS Physiology, Genetics and Preanalytics; Department of Medical and Clinical Genetics; HUSLAB |
| Publisher Information: |
Springer Nature in partnership with the Center of Excellence in Genomic Medicine Research |
| Publication Year: |
2026 |
| Collection: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| Subject Terms: |
Biomedicine; Genetics; developmental biology; physiology |
| Description: |
Nineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We meta-analyzed >22 million variants for 398,238 women from the Ovarian Cancer Association Consortium (OCAC), UK Biobank (UKBB) and Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) to identify novel HGSOC susceptibility loci. Eight novel variants were associated with HGSOC risk. An interesting discovery biologically was TP53 3’-UTR SNP rs78378222-T’s association with HGSOC (per-T-allele relative risk (RR) = 1.44, 95% CI:1.28–1.62, P = 1.76 × 10−9). Polygenic scores (PGS) were developed using OCAC and CIMBA data and trained on FinnGen data. The optimal PGS included 64,518 variants and was associated with an odds ratio of 1.46 (95% CI:1.37–1.54) per standard deviation when validated in the UKBB. This study represents the largest HGSOC GWAS to date – demonstrating that improvements in imputation reference panels and increased sample sizes help to identify HGSOC associated variants that previously went undetected, ultimately improving PGS which can improve personalized HGSOC risk prediction. ; Peer reviewed |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
RIS: urn:2D0562DCD83B13A69770B2B3DD987611; RIS: Barnes2025; https://hdl.handle.net/10138/625744; 105025377880; 001639168900001 |
| Availability: |
https://hdl.handle.net/10138/625744 |
| Rights: |
cc_by ; info:eu-repo/semantics/openAccess ; openAccess |
| Accession Number: |
edsbas.97E1FA7A |
| Database: |
BASE |