| Title: |
Low-dose CT for lung cancer screening in a high-risk population (SUMMIT): a prospective, longitudinal cohort study |
| Authors: |
Bhamani, Amyn; Creamer, Andrew; Verghese, Priyam; Prendecki, Ruth; Horst, Carolyn; Tisi, Sophie; Hall, Helen; Khaw, Chuen R; Mullin, Monica; McCabe, John; Gyertson, Kylie; Bowyer, Vicky; Arancon, Dominique; Eng, Jeannie; Bojang, Fanta; Levermore, Claire; Hacker, Anne-Marie; Arthur-Darkwa, Esther; Farrelly, Laura; Patel, Anant; Lock, Sara; Shaw, Alan; Banka, Rajesh; Bhowmik, Angshu; Ekeowa, Ugo; Mangera, Zaheer; Valerio, Christopher; Ricketts, William M; Mohammed, Ali; O'Shaughnessy, Terry; Navani, Neal; Quaife, Samantha L; Nair, Arjun; Devaraj, Anand; Janes, Sam M; Dickson, Jennifer L; Callender, Thomas; Khaw, Chuen; Ruparel, Mamta; Patrick, Tanya; Hackshaw, Allan; Teague, Jon; Chan, Kitty C; Sarpong, Rachael; Suresh, Malavika; El-Emir, Ethaar; Airebamen, Judy; Cotton, Alice; Phua, Kaylene; Murali, Elodie; Mehta, Simranjit; Zylstra, Janine; Parry-Billings, Karen; Ife, Columbus; Neville, April; Robinson, Paul; Green, Laura; Hanif, Zahra; Kiconco, Helen; McEwen, Ricardo; Beech, Nicholas; Ovayolu, Derya; Hosein, Christine; Enes, Sylvia P; Rowlands, Jane; Karavadra, Sheetal; Samson, Aashna; Patel, Urja P; Hoque, Fahmida; Pervez, Hina; Nnorom, Sofia; Miah, Moksud; McKee, Julian; Clark, Mark; Levermore, Fanta; SUMMIT consortium, . |
| Source: |
The Lancet Oncology (2025) (In press). |
| Publisher Information: |
Elsevier BV |
| Publication Year: |
2025 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
SUMMIT consortium |
| Description: |
Background: Low-dose CT screening reduces lung cancer mortality. In advance of planned national lung cancer screening programmes, research is needed to inform policies regarding implementation. We aimed to assess the implementation of low-dose CT for lung cancer screening in a high-risk population and to validate a multicancer early detection blood test.// Methods: In this prospective, longitudinal cohort study, individuals aged 55–77 years recorded as current smokers in their primary care records at any point within the past 20 years were identified from 329 primary care practices in London (UK) and invited for a lung health check via postal letter. Individuals meeting the 2013 United States Preventive Services Taskforce criteria (current or former smokers within the past 15 years with at least 30 pack-year smoking histories) or having a Prostate, Lung, Colorectal and Ovarian 2012 model 6-year risk of 1·3% or greater, and not currently receiving treatment for an active cancer (except adjuvant hormonal therapy), were eligible for the study. These individuals underwent lung cancer screening via non-contrast, thin collimation low-dose CT. In this analysis, we report the results of the baseline round of low-dose CT screening. Key primary endpoints were those associated with examining the performance of a lung cancer screening service. Outcome measures were analysed on a per-participant level using descriptive frequencies. The study was registered with ClinicalTrials.gov, NCT03934866.// Findings: Between April 8, 2019, and May 14, 2021, 12 773 participants were recruited and analysed. 7353 (57·6%) of 12 773 participants were male and 5420 (42·4%) were female, and 10 665 (83·5%) participants were White. 261 (2·0%) of 12 773 participants were diagnosed with lung cancer (including 163 [1·3%] participants with screen-detected lung cancer and 98 [0·8%] with delayed screen-detected lung cancer [ie, after a 3-month or 6-month nodule follow-up CT]) and 276 (2·2%) participants were diagnosed with any intrathoracic malignancy ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10206995/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10206995/1/Hackshaw_Low-dose%20CT%20for%20lung%20cancer%20screening_1-s2.0-S1470204525000828-main.pdf; https://discovery.ucl.ac.uk/id/eprint/10206995/ |
| Rights: |
open |
| Accession Number: |
edsbas.98073D35 |
| Database: |
BASE |