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Role of vitamin D and its receptor in regulation of mechanisms of immune inflammation in patients with ischemic heart disease ; Роль витамина D и его рецептора в регуляции механизмов воспаления у больных ишемической болезнью сердца

Title:	Role of vitamin D and its receptor in regulation of mechanisms of immune inflammation in patients with ischemic heart disease ; Роль витамина D и его рецептора в регуляции механизмов воспаления у больных ишемической болезнью сердца
Authors:	O. A. Berkovich; Zh. I. Ionova; J. Du; O. D. Belyaeva; О. А. Беркович; Ж. И. Ионова; Ц. Ду; О. Д. Беляева
Contributors:	This study was carried out as part of the State assignment of the Ministry of Health of the Russian Federation on the topic: “Molecular genetic predictors and morphological and functional phenotypes of heart failure with a preserved ejection fraction of the left ventricle in cardiomyopathies of various genesis” State Authorization № AAAA-A18-118070690073-2.; Работа выполнена в рамках государственного задания Министерства здравоохранения Российской Федерации № АААА-А18-118070690073-2 «Молекулярно-генетические предикторы и морфофункциональные фенотипы сердечной недостаточности с сохраненной фракцией выброса левого желудочка при кардиомиопатиях различного генеза».
Source:	Translational Medicine; Том 8, № 6 (2021); 5-14 ; Трансляционная медицина; Том 8, № 6 (2021); 5-14 ; 2410-5155 ; 2311-4495 ; undefined
Publisher Information:	Almazov National Medical Research Centre, Saint Petersburg, Russia
Publication Year:	2022
Collection:	Translational Medicine (E-Journal) / Трансляционная медицина
Subject Terms:	рецептор витамина D; coronary heart disease; immune inflammation; vitamin D; vitamin D deficiency; vitamin D receptor; витамин D; дефицит витамина D; иммунное воспаление; ишемическая болезнь сердца
Description:	Coronary heart disease still underlies high morbidity and mortality in people of working age. Thus, today one of the most important tasks facing clinical cardiology is the search for new molecular genetic predictors of coronary artery disease associated with the unfavorable course of this disease and the development of complications. In the present review, we analyzed the available data on the mechanisms of vitamin D interrelation with the development of immune inflammation in patients with coronary heart disease. The role of vitamin D and its receptor in cardiovascular diseases and in the development of coronary heart disease, in particular, is considered.Recent studies showed that vitamin D deficiency is a new risk factor for the development of atherosclerosis and immune inflammation. Immune damage of the vascular wall increases the risk of acute coronary syndrome, especially in patients with a predisposition to atherothrombosis. Vitamin D has a multilevel effect on immune inflammation mechanisms by restoring the balance in the system of pro- and anti-inflammatory cytokines. The protective effects of vitamin D on immune inflammation in the vascular wall are realized through vitamin D receptors. The present work re-viewed the studies describing possible mechanisms of immune inflammation regulation by vitamin D and its receptor and activation of immune inflammation in patients with vitamin D deficiency. Further studies of mechanisms of influence of vitamin D receptor on the suppression of immune inflammation are needed. ; Ишемическая болезнь сердца ассоциирована с высокой заболеваемостью и смертностью людей работоспособного возраста. Таким образом, одной из важнейших задач, стоящих сегодня перед клинической кардиологией, является поиск новых молекулярно-генетических предикторов ИБС, связанных с неблагоприятным течением этого заболевания и развитием осложнений. Предметом изучения в настоящем обзоре стало рассмотрение имеющихся данных о механизмах взаимосвязи витамина D c развитием иммунного воспаления у больных ...
Document Type:	article in journal/newspaper
File Description:	application/pdf
Language:	Russian
ISSN:	1672-7347
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DOI:	10.18705/2311-4495-2021-6-5-14
Availability:	https://transmed.almazovcentre.ru/jour/article/view/654; https://doi.org/10.18705/2311-4495-2021-6-5-14
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Accession Number:	edsbas.981C3C84
Database:	BASE