Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction
| Title: | Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction |
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| Authors: | Wood GK; Sargent BF; Ahmad Z-U-A; Tharmaratnam K; Dunai C; Egbe FN; Martin NH; Facer B; Pendered SL; Rogers HC; Hubel C; van Wamelen DJ; Bethlehem RAI; Giunchiglia V; Hellyer PJ; Kalsi G; Needham E; Easton A; Jackson TA; Cunningham C; Upthegrove R; Pollak TA; Hotopf M; Solomon T; Pett SL; Shaw PJ; Wood N; Harrison NA; Miller KL; Jezzard P; Williams G; Duff EP; Williams S; Zelaya F; Smith SM; Keller S; Broome M; Kingston N; Husain M; Vincent A; Bradley J; Chinnery P; Menon DK; Aggleton JP; Nicholson TR; Taylor J-P; David AS; Carson A; Bullmore E; Breen G; Hampshire A; Zandi MS; Wong SH; Venneri A; Veenith T; Underwood J; Trender W; Thomson E; Thomas RH; Tamborska A; Taams L; Smith J; Smith CJ; Singh B; Sieradzki A; Shil RSK; Semple S; Seed AW; Sawcer SJ; Samuel M; Salman RA-S; Rota S; Roberts A; Peacock S; Patel A; Palmos A; Ostermann M; Orazulume O; O'Malley R; Nicholas N; Newcombe V; Nair A; Mulholland C; Morris CM; Monssen D; McIntosh AM; McIlwaine R; McKeever S; McGlinchey E; McDonnell G; Martin N; Mansoori P; Madarshahian D; MacIver CL; Lunn MP; Lilleker JB; Lewis G; Kyaw S; Zvrskovec JK; Jenkins TM; Irani S; Hughes S; Huang Y; Holland AE; Hodel EM; Hiscox J; Hilton O; Hetherington C; Hartmann M; Harrison PJ; Harrison E; Harris JD; Hardwick M; Hamid SHM; Gunatilake S; Grundmann A; Grimbly V; Griffiths M; Gregory R; Glen K; George L; Garjani A; Galea I; Francis R; Fernandes PM; Evangelou N; Ellul MA; Duff E; Dregan A; Dodd KC; Defres S; Davies N; Darby A; Cousins D; Cossette N; Collie C; Coles A; Coleman JRI; Christmas DM; Christmas D; Cavanagh J; Castell H; Butler M; Breuer J; Breen DP; Boardman SA; Blackledge B; Berry A; Benjamin L; Batra R; Basu N; Barrett S; Baker MR; Armour C; Amin J; Allen CM; Al-Chalabi A; Alam AM; Michael BD; Paddick S-M; Leek EC |
| Source: | Nature Medicine, 2024 |
| Publisher Information: | Nature Research |
| Publication Year: | 2024 |
| Collection: | Newcastle University Library ePrints Service |
| Description: | © The Author(s) 2024.The spectrum, pathophysiology and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the 1-year cognitive, serum biomarker and neuroimaging findings from a prospective, national study of cognition in 351 COVID-19 patients who required hospitalization, compared with 2,927 normative matched controls. Cognitive deficits were global, associated with elevated brain injury markers and reduced anterior cingulate cortex volume 1 year after COVID-19. Severity of the initial infective insult, postacute psychiatric symptoms and a history of encephalopathy were associated with the greatest deficits. There was strong concordance between subjective and objective cognitive deficits. Longitudinal follow-up in 106 patients demonstrated a trend toward recovery. Together, these findings support the hypothesis that brain injury in moderate to severe COVID-19 may be immune-mediated, and should guide the development of therapeutic strategies. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | unknown |
| Relation: | https://eprints.ncl.ac.uk/302591; https://eprints.ncl.ac.uk/fulltext.aspx?url=302591/DD95C4C8-C6E0-45D0-9E69-F1BA937A3761.pdf&pub_id=302591 |
| Availability: | https://eprints.ncl.ac.uk/302591 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.9821BC7F |
| Database: | BASE |