| Title: |
Population-level impact of switching to 1-dose human papillomavirus vaccination in high-income countries: examining uncertainties using mathematical modeling |
| Authors: |
Brisson, Marc; Laprise, Jean-François; Drolet, Mélanie; Chamberland, Éléonore; Bénard, Élodie; Burger, Emily A; Jit, Mark; Kim, Jane J; Markowitz, Lauri E; Sauvageau, Chantal; Sy, Stephen |
| Contributors: |
Canadian Institute of Health Research Foundation; Bill & Melinda Gates Foundation; Single-Dose HPV vaccine consortium - PATH |
| Source: |
JNCI Monographs ; volume 2024, issue 67, page 387-399 ; ISSN 1052-6773 1745-6614 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2024 |
| Description: |
Background A concern in high-income countries is that switching to 1-dose human papillomavirus (HPV) vaccination could cause a rebound in HPV infection and cervical cancer if 1-dose efficacy or duration were inferior to 2 doses. Using mathematical modeling and up-to-date trial-based data, we projected the population-level effectiveness of switching from 2-dose to 1-dose vaccination under different vaccine efficacy and duration assumptions in high-income countries. Methods We used HPV-ADVISE (Agent-based Dynamic model for VaccInation and Screening Evaluation), a transmission-dynamic model of HPV infection and cervical cancer, varying key model assumptions to identify those with the greatest impact on projections of HPV-16 and cervical cancer incidence over time: 1) 1-dose vaccine efficacy and vaccine duration, 2) mechanisms of vaccine efficacy and duration over time, 3) midadult (>30 years of age) sexual behavior, 4) progression to cervical cancer among midadults, and 5) vaccination coverage and programs. Results In high-income countries, 1-dose vaccination would cause no appreciable rebound in HPV-16 infection, except for a limited rebound under the most pessimistic assumptions of vaccine duration (average, 25 years), because 1) the switch would occur when HPV prevalence is low because of high 2-dose vaccination coverage and 2) individuals would be protected during their peak ages of sexual activity ( |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/jncimonographs/lgae038 |
| Availability: |
https://doi.org/10.1093/jncimonographs/lgae038; https://academic.oup.com/jncimono/article-pdf/2024/67/387/60629497/lgae038.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.98C9390A |
| Database: |
BASE |