| Title: |
Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life |
| Authors: |
Santos García, Diego; Deus-Fonticoba, Teresa de; Cores Bartolomé, Carlos; Feal Painceiras, María; Íñiguez Alvarado, María Cristina; García Díaz, Iago; Jesús, Silvia; Buongiorno, María Teresa; Planellás, Lluis L.; Cosgaya, Marina; García Caldentey, Juan; Caballol, Núria; Legarda, Inés; Hernández Vara, Jorge; Cabo López, Iria; López Manzanares, Lydia; González Aramburu, Isabel; Ávila Rivera, María A.; Gómez Mayordomo, Víctor; Nogueira, Víctor; Puente, Víctor; Dotor, Julio; Borrue, Carmen; Solano Vila, Berta; Álvarez Saúco, María; Vela Desojo, Lydia; Escalante Arroyo, Sonia; Cubo Delgado, Esther; Carrillo Padilla, Francisco; Martínez Castrillo, Juan Carlos; Sánchez Alonso, Pilar; Alonso Losada, María Gema; López Ariztegui, Nuria; Gastón, Itziar; Kulisevsky Bojarsky, Jaume; Menéndez González, Manuel; Seijo, Manuel; Ruíz Martínez, Javier; Valero, Caridad; Kurtis, Mónica M.; González Ardura, Jessica; Alonso Redondo, Rubén; Ordás Bandera, Carlos Manuel; López Díaz, Luis M.; McAfee, Darrian; Calopa, Matilde; Carrillo, Fátima; Escamilla-Sevilla, Francisco; Freire-Alvarez, Eric; Gómez Esteban, Juan Carlos; García Ramos, Rocío; Luquin Piudo, Mª Rosario; Martínez Torres, Irene; Sesar Ignacio, Ángel; Martínez Martín, Pablo; Mir, Pablo |
| Publisher Information: |
IOS Press |
| Publication Year: |
2023 |
| Collection: |
Repositorio Institucional de la Universidad de Burgos (RIUBU) |
| Subject Terms: |
Axial symptoms; Cognition; MNCD classification; Non-motor symptoms; Parkinson’s disease; Quality of life; Sistema nervioso-Enfermedades; Medicina; Neurología; Nervous system-Diseases; Medicine; Neurology |
| Description: |
Background: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Objective: Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity. Methods: Data from the baseline visit of PD patients recruited from 35 centers in Spain from the COPPADIS cohort fromJanuary 2016 to November 2017 were used to apply the MNCD classification. Three instruments were used to assess QoL:1) the 39-item Parkinson's disease Questionnaire [PDQ-39]); PQ-10; the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Four hundred and thirty-nine PD patients (62.05±7.84 years old; 59% males) were included. MNCD stage was:stage 1, 8.4% (N = 37); stage 2, 62% (N = 272); stage 3, 28.2% (N = 124); stage 4-5, 1.4% (N = 6). A more advancedMNCD stage was associated with a higher score on the PDQ39SI (p < 0.0001) and a lower score on the PQ-10 (p< 0.0001) and EUROHIS-QOL8 (p< 0.0001). In many other aspects of the disease, such as disease duration, levodopa equivalent daily dose, motor symptoms, non-motor symptoms, and autonomy for activities of daily living, an association between the stage and severity was observed, with data indicating a progressive worsening related to disease progression throughout the proposed stages. Conclusion: Staging PD according to the MNCD classification correlated with QoL and disease severity. The MNCD could be a proper tool to monitor the progression of PD. ; The supplementary material is available in the electronic version of this article: https://dx.doi.org/ 10.3233/JPD-225073. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Journal of Parkinson's Disease. 2023, V. 13, n. 3, p. 379-402; https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd225073; http://hdl.handle.net/10259/8826 |
| DOI: |
10.3233/JPD-225073 |
| Availability: |
http://hdl.handle.net/10259/8826; https://doi.org/10.3233/JPD-225073 |
| Rights: |
Atribución-NoComercial 4.0 Internacional ; http://creativecommons.org/licenses/by-nc/4.0/ ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.99042907 |
| Database: |
BASE |