| Title: |
MRI‐Based Score to Recognize Thalamic Glioma Grade in Children: Morphology, Diffusion, and Arterial‐Spin‐Labeling Perfusion |
| Authors: |
Plasse, Alexis; Levy, Raphael; Tauziède‐espariat, Arnault; Agripnidis, Thibault; Hak, Jean-François; Roux, Charles-Joris; Samoyeau, Thomas; Ollitrault, Alexis; Beccaria, Kevin; Guida, Lelio; Blauwblomme, Thomas; Grill, Jacques; Dufour, Christelle; Guerrini-Rousseau, Léa; Bourdeaut, Franck; Doz, François; Varlet, Pascale; Boddaert, Nathalie; Dangouloff‐ros, Volodia; Hak, Jean‐françois; Roux, Charles‐joris |
| Contributors: |
Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité); Trajectoires développementales en psychiatrie : mesures et modélisations (ERL Inserm U1299); CB - Centre Borelli - UMR 9010 (CB); Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université Paris Cité (UPCité)-Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université Paris Cité (UPCité); Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm) |
| Source: |
ISSN: 1545-5009. |
| Publisher Information: |
CCSD; Wiley |
| Publication Year: |
2025 |
| Collection: |
Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| Subject Terms: |
Thalamus; MRI; Glioma; Children; Brain; MESH: Humans; MESH: Child; MESH: Spin Labels; MESH: Follow-Up Studies; MESH: Thalamus; MESH: Magnetic Resonance Imaging; MESH: Prognosis; MESH: Diffusion Magnetic Resonance Imaging; MESH: Female; MESH: Male; MESH: Glioma; MESH: Retrospective Studies; Preschool; MESH: Brain Neoplasms; MESH: Adolescent; MESH: Neoplasm Grading; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Purpose: Thalamic gliomas are found predominantly in children and can be classified into two main types with different prognoses and management: diffuse midline glioma (DMG) H3K27-altered and low-grade glioma (LGG). Our aim was to find imaging features distinguishing these tumors and to develop a diagnostic score.Patients and Methods: A retrospective study spanning September 1999 to May 2021 involved pediatric patients with thalamic gliomas, categorized into H3K27-altered DMG and LGG groups. Preoperative imaging, including morphology, diffusion, and arterial-spin-labeling perfusion, was reviewed blindly and compared between the two groups. A diagnostic score was formulated based on significant findings. Results were validated using an internal and external validation cohort.Results: Sixty-six patients were included (median age, 9 years; interquartile range [IQR] [5–13]; 38 girls) with 37 DMG H3K27-altered and 29 LGG. DMG H3K27-altered tumors exhibited larger volumes (median 64 cc, IQR [36–88] vs 26 cc, IQR [15–37], p< 0.001), greater heterogeneity in T2-weighted signal and enhancement (62% [22/37] vs 31% [9/29], p = 0.04, and 97% [32/33] vs 56% [15/27], p = 0.0008, respectively), lower minimum relative apparent diffusion coefficient (ADC) (0.92 (IQR [0.76–1.23]) vs 1.55 (IQR [1.40–1.72]), p < 0.001), and higher relative maximum cerebral blood flow (CBF) levels (2.08 (IQR [1.48–3.05]) vs 0.84(IQR [0.45–1]), p < 0.001). A diagnostic score integrating tumor diameter, solid content predominance, relative ADC, and relative CBF achieved 100% sensitivity and specificity in distinguishing DMG H3K27-altered tumors from LGG (full score available for 36patients), with good results in external and internal validation cohorts (12 patients).Conclusion: The morphological, diffusion, and arterial spin labeling imaging characteristics of pediatric thalamic tumors enable excellent differentiation of DMG H3K27-altered and LGG. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40213928; PUBMED: 40213928 |
| DOI: |
10.1002/pbc.31704 |
| Availability: |
https://u-paris.hal.science/hal-05121475; https://u-paris.hal.science/hal-05121475v1/document; https://u-paris.hal.science/hal-05121475v1/file/Pediatric%20Blood%20Cancer%20-%202025%20-%20Plasse%20-%20MRI%E2%80%90Based%20Score%20to%20Recognize%20Thalamic%20Glioma%20Grade%20in%20Children%20Morphology%20.pdf; https://doi.org/10.1002/pbc.31704 |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.99248BA9 |
| Database: |
BASE |