| Title: |
A randomized prospective mechanistic cardiac magnetic resonance study correlating catheter stability, late gadolinium enhancement and 3 year clinical outcomes in robotically assisted vs. standard catheter ablation. |
| Authors: |
Arujuna, A; Karim, R; Zarinabad, N; Gill, J; Rhode, K; Schaeffter, T; Wright, M; Rinaldi, CA; Cooklin, M; Razavi, R; O'Neill, MD; Gill, JS |
| Source: |
1250 ; 1241 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2014 |
| Collection: |
Imperial College London: Spiral |
| Subject Terms: |
Atrial fibrillation; Cardiac magnetic resonance imaging; Catheter ablation; Long-term follow-up; Pulmonary vein isolation; Robotic-assisted; Cardiovascular System & Hematology; 1103 Clinical Sciences |
| Description: |
To prospectively compare cardiac magnetic resonance late gadolinium enhancement (LGE) findings created by standard vs. robotically assisted catheter ablation lesions and correlate these with clinical outcomes.Forty paroxysmal atrial fibrillation patients (mean age 54 ± 13.8 years) undergoing first left atrial ablation were randomized to either robotic-assisted navigation (Hansen Sensei(®) X) or standard navigation. Pre-procedural, acute (24 h post-procedure) and late (beyond 3 months) scans were performed with LGE and T2W imaging sequences and percentage circumferential enhancement around the pulmonary vein (PV) antra were quantified. Baseline pre-procedural enhancements were similar in both groups. On acute imaging, mean % encirclements by LGE and T2W signal were 72% and 80% in the robotic group vs. 60% (P = 0.002) and 76%(P = 0.45) for standard ablation. On late imaging, the T2W signal resolved to baseline in both groups. Late gadolinium enhancement remained the predominant signal with 56% encirclement in the robotic group vs. 45% in the standard group (P = 0.04). At 6 months follow-up, arrhythmia-free patients had an almost similar mean LGE encirclement (robotic 64%, standard 60%, P = 0.45) but in recurrences, LGE was higher in the robotic group (43% vs. 30%, P = 0.001). At mean 3 years follow-up, 1.3 procedures were performed in the robotic group compared with 1.9 (P < 0.001) in the standard to achieve a success rate of 80% vs. 75%.Robotically assisted ablation results in greater LGE around the PV antrum. Effective lesions created through improved catheter stability and contact force during initial treatment may have a role in reducing subsequent re-do procedures. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Europace; http://hdl.handle.net/10044/1/30736; https://dx.doi.org/10.1093/europace/euu364 |
| DOI: |
10.1093/europace/euu364 |
| Availability: |
http://hdl.handle.net/10044/1/30736; https://doi.org/10.1093/europace/euu364 |
| Rights: |
© The Author 2015. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the CreativeCommonsAttribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Accession Number: |
edsbas.9931DCD5 |
| Database: |
BASE |