| Title: |
Integrated phenotyping of the anti-cancer immune response in HIV-associated hepatocellular carcinoma |
| Authors: |
Pinato, D. J.; Kaneko, T.; D'Alessio, A.; Forner, A.; Fessas, P.; Minguez, B.; Giannini, E. G.; Grillo, F.; Diaz, A.; Mauri, F. A.; Fulgenzi, C. A. M.; Dalla Pria, A.; Goldin, R. D.; Pieri, G.; Toniutto, P.; Avellini, C.; Plaz Torres, M. C.; Akarca, A. U.; Marafioti, T.; Bhoori, S.; Mirò, J. M.; Bower, M.; Brau, N; Mazzaferro, V. |
| Contributors: |
D.J. Pinato; T. Kaneko; A. D'Alessio; A. Forner; P. Fessa; B. Minguez; E.G. Giannini; F. Grillo; A. Diaz; F.A. Mauri; C.A.M. Fulgenzi; A. Dalla Pria; R.D. Goldin; G. Pieri; P. Toniutto; C. Avellini; M.C. Plaz Torre; A.U. Akarca; T. Marafioti; S. Bhoori; J.M. Mirò; M. Bower; N. Brau; V. Mazzaferro |
| Publisher Information: |
ELSEVIER |
| Publication Year: |
2023 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
HCC; HIV; PD-L1; Prognosis; Settore MED/18 - Chirurgia Generale |
| Description: |
Background & Aims: HIV-seropositivity shortens survival in patients with hepatocellular carcinoma (HCC). Although risk factors for HCC including HCV infection can influence T cell phenotype, it is unknown whether HIV can influence functional characteristics of the T cell infiltrate. Methods: From the Liver Cancer in HIV biorepository, we derived 129 samples of transplanted (76%) or resected (20%) HCC in eight European and North American centres. We profiled intra-and peritumoural tissue to evaluate regulatory CD4+/FOXP3+ and immune-exhausted CD8+/PD1+ T cells in HIV+ (n = 66) and HIV-(n = 63) samples. We performed targeted transcriptomics and T-cell receptor sequencing in a restricted subset of samples evaluated in relationship with HIV status. We correlated immunopathologic features with patients' characteristics including markers of HIV infection. Results: Of the 66 HIV+ patients, 83% were HCV coinfected with an undetectable HIV viral load (51%) and a median blood CD4+ cell count of 430 cells/mm3 (range 15-908). Patients who were HIV+ were compared with HIV-controls with similar staging characteristics including Barcelona Clinic Liver Cancer (BCLC) stage A-B (86% vs. 83%, p = 0.16), |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/37274775; info:eu-repo/semantics/altIdentifier/wos/WOS:001011203800001; volume:5; issue:7; firstpage:1; lastpage:12; numberofpages:12; journal:JHEP REPORTS; https://hdl.handle.net/2434/988568 |
| DOI: |
10.1016/j.jhepr.2023.100741 |
| Availability: |
https://hdl.handle.net/2434/988568; https://doi.org/10.1016/j.jhepr.2023.100741 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.99337AC5 |
| Database: |
BASE |