| Title: |
Long-term biological effects after acute 131 I-administration of two rat models (with and without thyroid) |
| Authors: |
Mezaguer-Lekouaghet, Meriem; Souidi, Maâmar; Hadjrabia, Samia; Mameri, Saâdia; Aït-Ziane, Mounir; Badreddine, Abdelwahab; Baz, Ahcène; Lounis-Mokrani, Zohra |
| Contributors: |
Centre de Recherche Nucléaire d’Alger.02Bd Frantz Fanon, Alger, Algérie; Laboratoire de Radiobiologie des expositions accidentelles (IRSN/PSE-SANTE/SERAMED/LRAcc); Service de recherche en radiobiologie et en médecine régénérative (IRSN/PSE-SANTE/SERAMED); Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN); Centre de Recherche Nucléaire de Draria. BP 43.Sebala. Draria, Alger, Algérie; Centre Hospitalo Universitaire Mustapha Bacha, Sidi M'Hamed, Alger, Algérie; Retired, Ecole Normale Supérieure de Kouba Vieux-Kouba, Alger, Algérie; Algiers Nuclear Research Center - CRNA; GTR IRSN - Réponse médicale et sanitaire face à des situations d'urgence radiologique et nucléaire (D3P14) |
| Source: |
ISSN: 0955-3002. |
| Publisher Information: |
CCSD; Taylor and Francis |
| Publication Year: |
2024 |
| Collection: |
IRSN (Institut de Radioprotection et de Sûreté Nucléaire): Publications (HAL |
| Subject Terms: |
radioiodine therapy biological effects ionizing radiation non-target organs and Wistar rat; radioiodine therapy; biological effects; ionizing radiation; non-target organs and Wistar rat; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Purpose: Radioiodine-131 (RAI or iodine-131) is one of the most frequently used radionuclides fordiagnosis and therapy of thyroid diseases (90% of all therapies in nuclear medicine). In order tooptimize the patient protection, it is important to evaluate the long-term biological effects of RAItherapy on non-target organs.Materials and methods: An experimental animal model has been adopted, it consists on mimingRAI therapy. An activity of RAI has been administrated in two models of Wistar rats: the first modelwith an intact thyroid gland (Thy + model), and the second one was thyroidectomized (Thy- model).For each model, 6 rats were orally contaminated with a solution 18.5 ± 1MBq of [131I]NaI and 6others rats were used as controls. The 24 rats have been placed in individual cages for a period of08 months then they were euthanized. The blood was collected by cardiac puncture and all organswere immediately removed. A fraction of thyroid, liver, kidneys and testicles was put in vialscontaining formaldehyde (10%) for histological investigation.Results: Histological observations show some liver disorders more accentuated in the case of theThy- model, the appearance of kidney tissue effects (hemosiderin deposits, fibrosis and glomerularnecrosis) for both models and an absence of any anomaly for the testicles slides. The disturbanceof blood parameters specific to each organ has been revealed.Conclusions: Long-term biological effect of 131I-administration shows the appearance of varioushistological disorders confirmed by disturbances in hepatic and renal functions. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1080/09553002.2024.2400484 |
| Availability: |
https://hal.science/hal-04832217; https://hal.science/hal-04832217v1/document; https://hal.science/hal-04832217v1/file/Long-term%20biological%20effects%20after%20acute%20131I-administration%20of%20two%20rat%20models%20%20with%20and%20without%20thyroid%20.pdf; https://doi.org/10.1080/09553002.2024.2400484 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.99564DD2 |
| Database: |
BASE |