| Title: |
Long-term outcomes after severe childhood malnutrition in adolescents in Malawi (LOSCM): a prospective observational cohort study. |
| Authors: |
Kirolos, Amir; Harawa, Philliness P; Chimowa, Takondwa; Divala, Oscar; Freyne, Bridget; Jones, Angus G; Lelijveld, Natasha; Lissauer, Samantha; Maleta, Kenneth; Gladstone, Melissa J; Kerac, Marko; CHANGE study collaborators group |
| Publisher Information: |
Elsevier BV |
| Publication Year: |
2024 |
| Collection: |
London School of Hygiene & Tropical Medicine: LSHTM Research Online |
| Description: |
BACKGROUND: Research on long-term outcomes of severe childhood malnutrition is scarce. Existing evidence suggests potential associations with cardiometabolic disease and impaired cognition. We aimed to assess outcomes in adolescents who were exposed to severe childhood malnutrition compared with peers not exposed to severe childhood malnutrition. METHODS: In Long-term Outcomes after Severe Childhood Malnutrition (LOCSM), we followed up adolescents who had 15 years earlier received treatment for severe childhood malnutrition at Queen Elizabeth Central Hospital in Blantyre, Malawi. Adolescents with previous severe childhood malnutrition included in LOCSM had participated in an earlier follow-up study (ChroSAM) at 7 years after treatment for severe childhood malnutrition, where they were compared to siblings and age-matched children in the community without previous severe childhood malnutrition. We measured anthropometry, body composition, strength, glucose tolerance, cognition, behaviour, and mental health during follow-up visits between Sept 9, 2021, and July 22, 2022, comparing outcomes in adolescents exposed to previous severe childhood malnutrition with unexposed siblings and adolescents from the community assessed previously (for ChroSAM) and newly recruited during current follow-up. We used a linear regression model to adjust for age, sex, disability, HIV, and socioeconomic status. This study is registered with the International Standard Randomised Controlled Trial Number Registry (ISRCTN17238083). FINDINGS: We followed up 168 previously malnourished adolescents (median age 17·1 years [IQR 16·5 to 18·0]), alongside 123 siblings (18·2 years [15·0 to 20·5]), and 89 community adolescents (17·1 years [16·3 to 18·1]). Since last measured 8 years previously, mean height-for-age Z (HAZ) scores had improved in previously malnourished adolescents (difference 0·33 [95% CI 0·20 to 0·46]) and siblings (0·32 [0·09 to 0·55]), but not in community adolescents (difference -0·01 [-0·24 to 0·23]). Previously malnourished ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
2352-4642 |
| Relation: |
https://researchonline.lshtm.ac.uk/id/eprint/4680039/1/Kirolos-etal-2024-Long-term-outcomes-after-severe.pdf; Kirolos, Amir; Harawa, Philliness P; Chimowa, Takondwa; Divala, Oscar; Freyne, Bridget; Jones, Angus G; Lelijveld, Natasha; Lissauer, Samantha; Maleta, Kenneth; Gladstone, Melissa J; +2 more.Kerac, Marko ORCID logo; and CHANGE study collaborators group (2024) Long-term outcomes after severe childhood malnutrition in adolescents in Malawi (LOSCM): a prospective observational cohort study. The Lancet. Child & adolescent health, 8 (4). pp. 280-289. ISSN 2352-4642 DOI:10.1016/S2352-4642(23)00339-5 |
| DOI: |
10.1016/s2352-4642(23)00339-5 |
| Availability: |
https://researchonline.lshtm.ac.uk/id/eprint/4680039/; https://doi.org/10.1016/s2352-4642(23)00339-5 |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.996CCF02 |
| Database: |
BASE |