| Title: |
Autonomic correlates of large muscle group movements during non-REM sleep in restless legs syndrome: a comparative analysis with periodic and non-periodic leg movements |
| Authors: |
Mogavero M. P.; Silvani A.; Lanza G.; Rundo F.; Bruni O.; Congiu P.; Puligheddu M.; Ferini Strambi L.; Ferri R. |
| Contributors: |
Mogavero, M. P.; Silvani, A.; Lanza, G.; Rundo, F.; Bruni, O.; Congiu, P.; Puligheddu, M.; Ferini Strambi, L.; Ferri, R. |
| Publication Year: |
2026 |
| Collection: |
IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| Subject Terms: |
arousal; autonomic nervous system; heart rate; isolated leg movements during sleep; large muscle group movement; periodic leg movements during sleep; restless legs syndrome; short-interval leg movements during sleep; sleep physiology |
| Description: |
Study Objectives Large muscle group movements during sleep (LMMS) have recently been recognized as a prevalent feature in patients with restless legs syndrome (RLS), yet their autonomic profile remains insufficiently characterized. This study aimed to compare heart rate (HR) changes associated with LMMS to those accompanying short-interval (SILMS), periodic (PLMS), and isolated leg movements (ISOLMS) during non-REM sleep in RLS. Methods Thirty drug-free RLS patients (20 women, mean age 57.6±12.73 years) underwent full-night polysomnography. For each subject, five arousal-associated events per movement type were selected, provided they were isolated by at least 30 seconds of motor/arousal-free sleep. HR changes were analyzed by computing R-R intervals and expressing them as a percentage of baseline, synchronized to movement onset. The area under the curve (AUC,−10 to +20 s), HR change peak, and movement durations were statistically compared using non-parametric tests. Results LMMS were significantly longer than other movement types (mean duration: 9.3 s vs. |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40652310; info:eu-repo/semantics/altIdentifier/wos/WOS:001554216600001; volume:49; issue:2; firstpage:1; lastpage:8; numberofpages:8; journal:SLEEP; https://hdl.handle.net/11585/1047150 |
| DOI: |
10.1093/sleep/zsaf194 |
| Availability: |
https://hdl.handle.net/11585/1047150; https://doi.org/10.1093/sleep/zsaf194 |
| Accession Number: |
edsbas.99933CF1 |
| Database: |
BASE |