| Title: |
Genome-wide association study meta-analysis of suicide attempt identifies twelve genome-wide significant loci and implicates genetic risks for specific health factors |
| Authors: |
Docherty, Anna, R; Mullins, Niamh; Ashley-Koch, Allison, E; Qin, Xuejun; Coleman, Jonathan, R I; Shabalin, Andrey; Kang, Jooeun; Murnyak, Balasz; Wendt, Frank; Adams, Mark; Campos, Adrian, I; Diblasi, Emily; Fullerton, Janice, M; Kranzler, Henry, R; Bakian, Amanda; Monson, Eric, T; Rentería, Miguel, E; Walss-Bass, Consuelo; Andreassen, Ole, A; Bulik, Cynthia, M; Edenberg, Howard, J; Kessler, Ronald, C; Mann, J, John; Nurnberger, John, I; Pistis, Giorgio; Streit, Fabian; Ursano, Robert, J; Polimonti, Renato; Dennis, Michelle; Garrett, Melanie; Hair, Lauren; Harvey, Philip; Hauser, Elizabeth, R; Hauser, Michael, A; Huffman, Jennifer; Jacobson, Daniel; Lindquist, Jennifer, H; Madduri, Ravi; Mcmahon, Benjamin; Oslin, David, W; Trafton, Jodie; Awasthi, Swapnil; Bergen, Andrew, W; Berrettini, Wade, H; Bohus, Martin; Brandt, Harry; Chang, Xiao; Chen, Hsi-Chung; Chen, Wei, J; Christensen, Erik, D; Crawford, Steven; Crow, Scott; Duriez, Philibert; Edwards, Alexis, C; Fernández-Aranda, Fernando; Fichter, Manfred, M; Galfalvy, Hanga; Gallinger, Steven; Gandal, Michael; Gorwood, Philip; Guo, Yiran; Hafferty, Jonathan, D; Hakonarson, Hakon; Halmi, Katherine, A; Hishimoto, Akitoyo; Jain, Sonia; Jamain, Stéphane; Jiménez-Murcia, Susana; Johnson, Craig; Kaplan, Allan, S; Kaye, Walter, H; Keel, Pamela, K; Kennedy, James, L; Kim, Minsoo; Klump, Kelly, L; Levey, Daniel, F; Li, Dong; Liao, Shih-Cheng; Lieb, Klaus; Lilenfeld, Lisa; Lori, Adriana; Magistretti, Pierre, J; Marshall, Christian, R; Mitchell, James, E; Myers, Richard, M; Okazaki, Satoshi; Otsuka, Ikuo; Pinto, Dalila; Powers, Abigail; Ramoz, Nicolas; Ripke, Stephan; Roepke, Stefan; Rozanov, Vsevolod; Scherer, Stephen, W; Schmahl, Christian; Sokolowski, Marcus; Starnawska, Anna; Strober, Michael; Su, Mei-Hsin; Thornton, Laura, M; Treasure, Janet; Ware, Erin, B; Watson, Hunna, J; Witt, Stephanie, H; Woodside, D, Blake; Yilmaz, Zeynep; Zillich, Lea; Adolfsson, Rolf; Agartz, Ingrid; Air, Tracy, M; Alda, Martin; Alfredsson, Lars; Anjorin, Adebayo; Appadurai, Vivek; Artigas, María, Soler; van der Auwera, Sandra; Azevedo, M, Helena; Bass, Nicholas; Bau, Claiton, Hd; Baune, Bernhard, T; Bellivier, Frank; Berger, Klaus; Biernacka, Joanna, M; Bigdeli, Tim, B; Binder, Elisabeth, B; Boehnke, Michael; Boks, Marco, P; Bosch, Rosa; Braff, David, L; Bryant, Richard; Budde, Monika; Byrne, Enda, M; Cahn, Wiepke; Casas, Miguel; Castelao, Enrique; Cervilla, Jorge, A; Chaumette, Boris; Cichon, Sven; Corvin, Aiden; Craddock, Nicholas; Craig, David; Degenhardt, Franziska; Djurovic, Srdjan; Fanous, Ayman, H; Foo, Jerome, C; Forstner, Andreas, J; Frye, Mark; Gatt, Justine, M; Gejman, Pablo, V; Giegling, Ina; Grabe, Hans, J; Green, Melissa, J; Grevet, Eugenio, H; Grigoroiu-Serbanescu, Maria; Gutierrez, Blanca; Guzman-Parra, Jose; Hamilton, Steven, P; Hamshere, Marian, L; Hartmann, Annette, M; Hauser, Joanna; Heilmann-Heimbach, Stefanie; Hoffmann, Per; Ising, Marcus; Jones, Ian; Jones, Lisa, A; Jonsson, Lina; Kahn, René, S; Kelsoe, John, R; Kendler, Kenneth, S; Kloiber, Stefan; Koenen, Karestan, C; Kogevinas, Manolis; Konte, Bettina; Krebs, Marie-Odile; Landén, Mikael; Lawrence, Jacob; Leboyer, Marion; Lee, Phil, H; Levinson, Douglas, F; Liao, Calwing; Lissowska, Jolanta; Lucae, Susanne; Mayoral, Fermin; Mcelroy, Susan, L; Mcgrath, Patrick; Mcguffin, Peter; Mcquillin, Andrew; Mehta, Divya; Melle, Ingrid; Milaneschi, Yuri; Mitchell, Philip, B; Molina, Esther; Morken, Gunnar; Mortensen, Preben, Bo; Müller-Myhsok, Bertram; Nievergelt, Caroline; Nimgaonkar, Vishwajit; Nöthen, Markus, M; O’donovan, Michael, C; Ophoff, Roel, A; Owen, Michael, J; Pato, Carlos; Pato, Michele, T; Penninx, Brenda, Wjh; Pimm, Jonathan; Potash, James, B; Power, Robert, A; Preisig, Martin; Quested, Digby; Ramos-Quiroga, Josep, Antoni; Reif, Andreas; Ribasés, Marta; Richarte, Vanesa; Rietschel, Marcella; Rivera, Margarita; Roberts, Andrea; Roberts, Gloria; Rouleau, Guy, A; Rovaris, Diego, L; Rujescu, Dan; Sánchez-Mora, Cristina; Sanders, Alan, R; Schofield, Peter, R; Schulze, Thomas, G; Scott, Laura, J; Serretti, Alessandro; Shi, Jianxin; Shyn, Stanley, I; Sirignano, Lea; Sklar, Pamela; Smeland, Olav, B; Smoller, Jordan, W; Sonuga-Barke, Edmund, J S; Spalletta, Gianfranco; Strauss, John, S; Świątkowska, Beata; Trzaskowski, Maciej; Tsuang, Ming, T; Turecki, Gustavo; Vilar-Ribó, Laura; Vincent, John, B; Völzke, Henry; Walters, James, Tr; Weickert, Cynthia, Shannon; Weickert, Thomas, W; Weissman, Myrna, M; Williams, Leanne, M; Wray, Naomi, R; Zai, Clement, C; Agerbo, Esben; Børglum, Anders, D; Breen, Gerome; Demontis, Ditte; Erlangsen, Annette; Esko, Tõnu; Gelernter, Joel; Glatt, Stephen, J; Hougaard, David, M; Hwu, Hai-Gwo; Kuo, Po-Hsiu; Lewis, Cathryn, M; Li, Qingqin, S; Liu, Chih-Min; Martin, Nicholas, G; Mcintosh, Andrew, M; Medland, Sarah, E; Mors, Ole; Nordentoft, Merete; Olsen, Catherine, M; Porteous, David; Smith, Daniel, J; Stahl, Eli, A; Stein, Murray, B; Wasserman, Danuta; Werge, Thomas; Whiteman, David, C; Willour, Virginia; Coon, Hilary; Beckham, Jean, C; Kimbrel, Nathan, A; Ruderfer, Douglas, M |
| Contributors: |
School of Medicine University of Utah, Salt Lake City; University of Utah; J. Craig Venter Institute; Swinburne University of Technology Melbourne; The University of Queensland (UQ All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations ); University of New South Wales Kensington; Perelman School of Medicine; University of Pennsylvania Philadelphia; University of Oslo (UiO); Oslo University Hospital Oslo; Karolinska Institutet = Karolinska Institute Stockholm; Université de Caroline du Nord à Chapel Hill = University of North Carolina Chapel Hill (UNC-Chapel Hill); University of North Carolina System (UNC); Harvard Medical School Boston (HMS); Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University Milan, Italie (UniSR); University Medical Center Heidelberg; IMRB - "Neuropsychiatrie translationnelle" Créteil (U955 Inserm - UPEC); Institut Mondor de Recherche Biomédicale (IMRB); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) |
| Source: |
https://inserm.hal.science/inserm-04197646 ; 2023. |
| Publisher Information: |
CCSD |
| Publication Year: |
2023 |
| Collection: |
Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| Subject Terms: |
[SDV]Life Sciences [q-bio] |
| Description: |
Objective Suicidal behavior is heritable and a major cause of death worldwide. Two large-scale genome-wide association studies (GWAS) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The current study leveraged the genetic cohorts from both studies to conduct the largest GWAS meta-analysis of SA to date. Multi-ancestry and admixture-specific meta-analyses were conducted within groups of significant African, East Asian, and European ancestry admixtures. Methods This study was comprised of 22 cohorts, including 43,871 SA cases and 915,025 ancestry-matched controls. Analytical methods across multi-ancestry and individual ancestry admixtures included inverse variance-weighted fixed effects meta-analyses, followed by gene, gene-set, tissue-set, and drug-target enrichment, as well as summary-data-based Mendelian Randomization with brain eQTL data, phenome-wide genetic correlation, and genetic causal proportion analyses. Results Multi-ancestry and European ancestry admixture GWAS meta-analyses identified 12 risk loci at p |
| Document Type: |
report |
| Language: |
English |
| Relation: |
MEDRXIV: 2022.07.03.22277199 |
| DOI: |
10.1101/2022.07.03.22277199 |
| Availability: |
https://inserm.hal.science/inserm-04197646; https://inserm.hal.science/inserm-04197646v1/document; https://inserm.hal.science/inserm-04197646v1/file/2022.07.03.22277199v3.full.pdf; https://doi.org/10.1101/2022.07.03.22277199 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.9995F314 |
| Database: |
BASE |