| Title: |
Mutation of the PRE1 and its associated PRE-like in p AGA1 slows down response time. |
| Authors: |
Sandrine Pinheiro; Mariona Nadal-Ribelles; Carme Solé; Vincent Vincenzetti; Yves Dusserre; Francesc Posas; Serge Pelet |
| Publication Year: |
2025 |
| Collection: |
The University of Auckland: Figshare |
| Subject Terms: |
Microbiology; Cell Biology; Genetics; Molecular Biology; Immunology; Developmental Biology; Science Policy; Infectious Diseases; Plant Biology; Biological Sciences not elsewhere classified; two haploid cells; saccharomyces cerevisiae < p; core promoter modulate; ste12 binding sites; binding sites; strong dimer; specific timing; largely encoded; large diversity; basal association |
| Description: |
A. Scheme of the p AGA1 endogenous promoter, which contains three consensus PRE sites and at least five non-consensus ones. PRE2 together with a non-consensus PRE spaced by 3 bp in tail-to-tail orientation are essential for the inducibility of the promoter. PRE1 (closest to the core) is spaced by 5 bp from a non-consensus site in tail to head conformation. PRE1 or its associated PRE-like have been mutated. B. Dynamics of nuclear enrichment of the dPSTR R under the control of the endogenous (dark blue) or the mutated (light blue or magenta) AGA1 promoter. The solid line represents the median of the population and the shaded area the 25–75- percentile of the population. C. Histogram of the difference in response time between the tested promoters and the internal p AGA1 -dPSTR Y reference. The T indicates that the histograms for the two mutated promoters are significantly different from the endogenous promoter using a Wilcoxon rank sum test. (PDF) |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| DOI: |
10.1371/journal.pgen.1011710.s007 |
| Availability: |
https://doi.org/10.1371/journal.pgen.1011710.s007; https://figshare.com/articles/journal_contribution/Mutation_of_the_PRE1_and_its_associated_PRE-like_in_p_i_AGA1_i_slows_down_response_time_/29332264 |
| Rights: |
CC BY 4.0 |
| Accession Number: |
edsbas.999D45ED |
| Database: |
BASE |