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Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition

Title:	Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition
Authors:	Mikropoulos, Christos; Selkirk, Christina G Hutten; Saya, Sibel; Bancroft, Elizabeth; Vertosick, Emily; Dadaev, Tokhir; Brendler, Charles; Page, Elizabeth; Dias, Alexander; Evans, D Gareth; Rothwell, Jeanette; Nicolai, Nicola; Greenhalgh, Lynn; Obeid, Elias; Murthy, Vedang; Copakova, Lucia; McGrath, John; Teo, Soo-Hwang; Strom, Sara; Kast, Karin; Leongamornlert, Daniel A; Foster, Christopher S; Chamberlain, Anthony; Pope, Jenny; Newlin, Anna C; Aaronson, Neil; Ardern-Jones, Audrey; Bangma, Chris; Castro, Elena; Dearnaley, David; Eyfjord, Jorunn; Falconer, Alison; Gronberg, Henrik; Hamdy, Freddie C; Johannsson, Oskar; Khoo, Vincent; Lubinski, Jan; Grindedal, Eli Marie; McKinley, Joanne; Shackleton, Kylie; Mitra, Anita V; Maehle, Lovise; Moynihan, Clare; Rennert, Gad; Suri, Mohnish; Tricker, Karen; Moss, Sue; Kote-Jarai, Zsofia; Vickers, Andrew; Lilja, Hans; Helfand, Brian T; Eeles, Rosalind A; Axcrona, Karol; Richardson, Kate; Eccles, Diana; Jensen, Thomas; Osther, Palle J; van Asperen, Christi J; Vasen, Hans; Kiemeney, Lambertus A; Ringelberg, Janneke; Cybulski, Cezary; Wokolorczyk, Dominika; Hart, Rachel; Glover, Wayne; Lam, Jimmy; Taylor, Louise; Salinas, Monica; Feliubadaló, Lidia; Oldenburg, Rogier; Cremers, Ruben; Verhaegh, Gerald; van Zelst-Stams, Wendy A; Oosterwijk, Jan C; Cook, Jackie; Rosario, Derek J; Buys, Saundra S; Conner, Tom; Domchek, Susan; Powers, Jacquelyn; Ausems, Margreet GEM; Teixeira, Manuel R; Maia, Sofia; Izatt, Louise; Schmutzler, Rita; Rhiem, Kerstin; Foulkes, William D; Boshari, Talia; Davidson, Rosemarie; Ruijs, Marielle; Helderman-van den Enden; Apollonia TJM; Andrews, Lesley; Walker, Lisa; Snape, Katie; Henderson, Alex; Jobson, Irene; Lindeman, Geoffrey J; Liljegren, Annelie; Harris, Marion; Adank, Muriel A; Kirk, Judy; Taylor, Amy; Susman, Rachel; Chen-Shtoyerman, Rakefet; Pachter, Nicholas; Spigelman, Allan; Side, Lucy; Zgajnar, Janez; Mora, Josefina; Brewer, Carole; Gadea, Neus; Brady, Angela F; Gallagher, David; van Os, Theo; Donaldson, Alan; Stefansdottir, Vigdis; Barwell, Julian; James, Paul A; Murphy, Declan; Friedman, Eitan
Contributors:	Show more 1 Inst Canc Res, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England 2 North Shore Univ Hlth Syst, Dept Surg, John & Carol Walter Ctr Urol Hlth, Evanston, IL 60201 USA 3 North Shore Univ Hlth Syst, Dept Med, Ctr Med Genet, Evanston, IL 60201 USA Show more 4 Royal Marsden NHS Fdn Trust, Fulham Rd, London SW3 6JJ, England Show more 5 Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA Show more 6 Univ Manchester, Cent Manchester Univ Hosp NHS Fdn Trust, Div Evolut & Genom Sci, Gen Med Manchester Acad Hlth Sci Ctr, Manchester M13 9WL, Lancs, England Show more 7 Oslo Univ Hosp, Dept Med Genet, N-0372 Oslo, Norway Show more 8 Akershus Univ Hosp, N-1478 Lorenskog, Norway Show more 9 Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic 3000, Australia Show more 10 Sir Peter MacCallum Dept Oncol, Melbourne, Vic 3010, Australia 11 Princess Anne Hosp, Wessex Clin Genet Serv, Southampton SO16 5YA, Hants, England Show more 12 Univ Southampton, Univ Hosp Southampton NHS Fdn Trust, Cancer Sci Fac Med, Southampton SO16 6YD, Hants, England 13 Vejle Hosp, Dept Clin Genet, DK-7100 Vejle, Denmark Show more 14 Leiden Univ, Med Ctr, Dept Clin Genet, NL-2333 ZA Leiden, Netherlands 15 Netherlands Fdn Detect Hereditary Tumors, NL-2333 Nijmegen, GA, Netherlands Show more 16 Radboud Univ Nijmegen, Med Ctr, NL-6525 Nijmegen, GA, Netherlands Show more 17 Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, PL-70204 Szczecin, Poland 18 Birmingham Womens Hosp, Clin Genet Unit, Birmingham B15 2TG, W Midlands, England 19 Repatriat Gen Hosp, Dept Urol, Daw Pk, SA 5041, Australia Show more 20 Hosp Llobregat, Catalan Inst Oncol, ICO IDIBELL, CIBERONC,Hereditary Canc Program, Barcelona 08908, Spain 21 Erasmus MC, Dept Clin Genet, NL-3015 Rotterdam, Netherlands Show more 22 Univ Med Ctr Groningen, Univ Groningen, Dept Genet, NL-9713 Groningen, Netherlands 23 Sheffield Childrens Hosp, Sheffield Clin Genet Serv, Sheffield S10 2TH, S Yorkshire, England Show more 24 Royal Hallamshire Hosp, Sheffield S10 2JF, S Yorkshire, England Show more 25 Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84103 USA Show more 26 Univ Penn, Basser Res Ctr, Philadelphia, PA 19104 USA Show more 27 Univ Med Ctr Utrecht, Dept Genet, Utrecht, CX, Netherlands Show more 28 Portuguese Oncol Inst, Genet Dept, P-4200072 Oporto, Portugal Show more 29 Portuguese Oncol Inst, Res Ctr, P-4200072 Oporto, Portugal Show more 30 Univ Porto, Biomed Sci Inst ICBAS, P-4200072 Oporto, Portugal Show more 31 Guys Hosp, South East Thames Genet Serv, London SE1 9RT, England Show more 32 Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, D-50829 Cologne, Germany Show more 33 McGill Univ, Dept Oncol, McGill Program Canc Genet, Montreal, PQ, Canada Show more 34 McGill Univ, Dept Human Genet, Montreal, PQ, Canada 35 Duncan Guthrie Inst Med Genet, Yorkhill NHS Trust, Glasgow G38SJ, Lanark, Scotland Show more 36 Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands Show more 37 Maastricht Univ, Med Ctr, Dept Clin Genet, NL-6229 HX Maastricht, Netherlands Show more 38 Prince Wales Hosp, Hereditary Canc Clin, Randwick, NSW 2031, Australia Show more 39 Churchill Hosp, Oxford OX3 7LE, England Show more 40 St George Hosp, London SW17 0QT, England 41 Newcastle Upon Tyne Hosp, Northern Genet Serv, Newcastle NE1 3BZ, England 42 Royal Melbourne Hosp, Parkville Familial Canc Ctr, Grattan St, Parkville, Vic 3050, Australia Show more 43 Walter & Eliza Hall Inst Med Res, Stem Cells & Canc Div, Parkville, Vic 3050, Australia Show more 44 Univ Melbourne, Dept Med, Parkville, Vic 3050, Australia Show more 45 Karolinska Univ Hosp, S-17184 Solna, Sweden Show more 46 Karolinska Inst, S-17184 Solna, Sweden 47 Monash Hlth, Familial Canc Ctr, Clayton, Vic 3168, Australia Show more 48 Vrije Univ Amsterdam Med Ctr, NL-1081 HV Amsterdam, Netherlands Show more 49 Westmead Hosp, Familial Canc Serv, Sydney, NSW 2145, Australia Show more 50 Westmead Inst Med Res, Ctr Canc Res, Sydney, NSW 2155, Australia Show more 51 Cambridge Univ Hosp NHS Fdn Trust, Cambridge CB2 0QQ, England 52 Royal Brisbane & Womens Hosp, Genet Hlth Queensland, Herston, Qld 4029, Australia Show more 53 Kaplan Med Ctr, Genet Inst, IL-76100 Rehovot, Israel Show more 54 King Edward Mem Hosp, Genet Serv WA, Subiaco, WA 6008, Australia Show more 55 Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6009, Australia 56 Hunter Family Canc Serv, Waratah, NSW 2298, Australia Show more 57 Univ New South Wales, St Vincents Clin Sch, Sydney, NSW 2052, Australia Show more 58 St Vincents Hosp, Kinghorn Canc Ctr, Sydney, NSW 2010, Australia Show more 59 Great Ormond St Hosp Sick Children, NE Thames Reg Genet Serv, London WC1N 3JH, England Show more 60 UCL Inst Womens Hlth, London WC1N 3JH, England Show more 61 Inst Oncol, Ljubljana 1000, Slovenia Show more 62 Hosp Santa Creu & Sant Pau, Barcelona 08041, Spain 63 Derriford Hosp, Peninsular Genet, Plymouth PL6 8DH, Devon, England Show more 64 Royal Devon & Exeter Hosp, Exeter EX2 5DW, Devon, England Show more 65 Vall dHebron Univ Hosp, High Risk & Canc Prevent Clin, Barcelona 08035, Spain 66 London North West Healthcare NHS Trust, North West Thames Reg Genet Serv, Harrow HA1 3UJ, Middx, England Show more 67 St James Hosp, Dublin 8, Ireland 68 Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands 69 St Michaels Hosp, Bristol BS2 8EG, Avon, England 70 Landspitali Natl Univ Hosp Iceland, IS-101 Reykjavik, Iceland Show more 71 Univ Leicester, Leicester LE1 7RH, Leics, England Show more 72 Univ Hosp Leicester, Leicester LE1 5WW, Leics, England 73 Royal Melbourne Hosp, Genet Med, Melbourne, Vic 3050, Australia Show more 74 Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel Show more 75 Tel Aviv Univ, Sackler Sch Med, IL-6997801 Tel Aviv, Israel Show more 76 Ist Nazl Tumori, I-20133 Milan, Italy Show more 77 Liverpool Womens Hosp, Cheshire & Mersey Clin Genet Serv, Liverpool L8 7SS, Merseyside, England Show more 78 Fox Chase Canc Ctr, Philadelphia, PA 19111 USA Show more 79 Tata Mem Hosp, Mumbai 400012, Maharashtra, India 80 Natl Canc Inst, Bratislava 83310, Slovakia 81 Subang Jaya Med Ctr, Canc Res Initiat Fdn, Subang Jaya, Selangor 47500, Malaysia Show more 82 Univ Texas Houston, MD Anderson Canc Ctr, Houston, TX 77030 USA Show more 83 Tech Univ Dresden, Dept Gynecol & Obstet, Fac Med, D-01069 Dresden, Germany Show more 84 Tech Univ Dresden, Univ Hosp Carl Gustav Carus, D-01069 Dresden, Germany Show more 85 Natl Ctr Tumor Dis NCT, Partner Site Dresden, D-01307 Dresden, Germany Show more 86 Dresden & German Canc Res Ctr DKFZ, German Canc Consortium DKTK, D-69120 Heidelberg, Germany Show more 87 Spanish Natl Canc Res Ctr, Prostate Canc Unit, Madrid 28029, Spain Show more 88 Univ Iceland, Sch Hlth Sci, Fac Med, IS-101 Reykjavik, Iceland Show more 89 Imperial Coll Healthcare NHS Trust, London W2 1NY, England 90 HCA Healthcare Labs, London WC1E 6JA, England Show more 91 Univ Hosp, S-90737 Umea, Sweden Show more 92 Univ Oxford, Nuffield Dept Surg Sci, Oxford OX1 2JD, England Show more 93 Univ Coll London Hosp NHS Fdn Trust, London NW1 2BU, England 94 CHS Natl Canc Control Ctr, Carmel Med Ctr, IL-31999 Haifa, Israel 95 City Hosp Nottingham, Nottingham NG5 1PB, England 96 IMPACT Study Collaborators List See Appendix 1, Nottingham, England Show more 97 Queen Mary Univ London, Ctr Canc Prevent, London EC1M 6BQ, England Show more 98 Mem Sloan Kettering Canc Ctr, Dept Lab Med, New York, NY 10065 USA Show more 99 Mem Sloan Kettering Canc Ctr, Dept Surg & Med, New York, NY 10065 USA Show more 100 Lund Univ, Dept Translat Med, S-20502 Malmo, Sweden
Publisher Information:	Nature Publishing Group
Publication Year:	2018
Collection:	Hirsla - Landspítali University Hospital research archive
Subject Terms:	Blöðruhálskirtilskrabbamein; Kembileit; NAF12; Prostatic Neoplasms; Mass Screening; Antigens
Description:	To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files ; BACKGROUND: Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort. METHODS: PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in men with elevated PSA values. Cox regression was used to determine whether PSA or PSAV predicted PSA elevation in men with low PSAs. Interaction terms were included in the models to determine whether BRCA status influenced the predictiveness of PSA or PSAV. RESULTS: 1634 participants had ⩾3 PSA readings of whom 174 underwent PB and 45 PrCas diagnosed. In men with PSA >3.0 ng ml-l, PSAV was not significantly associated with presence of cancer or high-grade disease. PSAV did not add to PSA for predicting time to an elevated PSA. When comparing BRCA1/2 carriers to non-carriers, we found a significant interaction between BRCA status and last PSA before biopsy (P=0.031) and BRCA2 status and PSAV (P=0.024). However, PSAV was not predictive of biopsy outcome in BRCA2 carriers. CONCLUSIONS: PSA is more strongly predictive of PrCa in BRCA carriers than non-carriers. We did not find evidence that PSAV aids decision-making for BRCA carriers over absolute PSA value alone. ; Cancer Research UK Ronald and Rita McAulay Foundation NIHR Oxford Biomedical Research Centre Program Cancer Council Tasmania Cancer Australia Prostate Cancer Foundation of Australia Cancer Council of Victoria Cancer Council of South Australia Victorian Cancer Agency Clinical Trial Capacity Cancer Australia & Prostate Cancer Foundation of Australia Association of International Cancer ...
Document Type:	article in journal/newspaper
Language:	English
ISSN:	0007-0920; 1532-1827
Relation:	http://www.nature.com/doifinder/10.1038/bjc.2017.429; Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition 2018, 118 (2):266 British Journal of Cancer; http://hdl.handle.net/2336/620466; British Journal of Cancer
DOI:	10.1038/bjc.2017.429
Availability:	http://hdl.handle.net/2336/620466; https://doi.org/10.1038/bjc.2017.429
Rights:	Archived with thanks to British Journal of Cancer ; Open Access - Opinn aðgangur
Accession Number:	edsbas.99DF1331
Database:	BASE