| Title: |
MARS spectral molecular imaging of lamb tissue: data collection and image analysis |
| Authors: |
Aamir, R; Chernoglazov, AI; Bateman, CJ; Butler, APH; Butler, PH; Anderson, NG; Bell, ST; Panta, RK; Healy, JL; Mohr, JL; Rajendran, K; Walsh, MF; de Ruiter, NJA; Gieseg, SP; Woodfield, TBF; Renaud, PF; Brooke, L; Abdul-Majid, S; Clyne, M; Glendenning, R; Bones, PJ; Billinghurst, M; Bartneck, C; Mandalika, H; Grasset, R; Schleich, N; Scott, N; Nik, SJ; Opie, A; Janmale, T; Tang, DN; Kim, D; Doesburg, RM; Zainon, R; Ronaldson, JP; Cook, NJ; Smithies, DJ; Hodge, K |
| Publisher Information: |
IOP Publishing for SISSA Medialab |
| Collection: |
Lincoln University (New Zealand): Lincoln U Research Archive |
| Subject Terms: |
x-ray detectors; computerized tomography (CT); computed radiography (CR); medical-image reconstruction methods and algorithms; computer-aided diagnosis; data acquisition concepts; ANZSRC::07 Agricultural and Veterinary Sciences; ANZSRC::11 Medical and Health Sciences; ANZSRC::110320 Radiology and Organ Imaging; ANZSRC::40 Engineering; ANZSRC::51 Physical sciences |
| Description: |
Spectral molecular imaging is a new imaging technique able to discriminate and quantify different components of tissue simultaneously at high spatial and high energy resolution. Our MARS scanner is an x-ray based small animal CT system designed to be used in the diagnostic energy range (20–140 keV). In this paper, we demonstrate the use of the MARS scanner, equipped with the Medipix3RX spectroscopic photon-processing detector, to discriminate fat, calcium, and water in tissue. We present data collected from a sample of lamb meat including bone as an illustrative example of human tissue imaging. The data is analyzed using our 3D Algebraic Reconstruction Algorithm (MARS-ART) and by material decomposition based on a constrained linear least squares algorithm. The results presented here clearly show the quantification of lipid-like, water-like and bone-like components of tissue. However, it is also clear to us that better algorithms could extract more information of clinical interest from our data. Because we are one of the first to present data from multi-energy photon-processing small animal CT systems, we make the raw, partial and fully processed data available with the intention that others can analyze it using their familiar routines. The raw, partially processed and fully processed data of lamb tissue along with the phantom calibration data can be found at https://hdl.handle.net/10092/8531. |
| Document Type: |
article in journal/newspaper |
| File Description: |
12 pages |
| Language: |
English |
| Relation: |
The original publication is available from IOP Publishing for SISSA Medialab - https://doi.org/10.1088/1748-0221/9/02/P02005 - https://doi.org/10.1088/1748-0221/9/02/p02005; Journal of Instrumentation; https://doi.org/10.1088/1748-0221/9/02/P02005; https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=elements_prod&SrcAuth=WosAPI&KeyUT=WOS:000332314400040&DestLinkType=FullRecord&DestApp=WOS_CPL; AC2FL (isidoc); https://hdl.handle.net/10182/8860 |
| DOI: |
10.1088/1748-0221/9/02/P02005 |
| Availability: |
https://hdl.handle.net/10182/8860; https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=elements_prod&SrcAuth=WosAPI&KeyUT=WOS:000332314400040&DestLinkType=FullRecord&DestApp=WOS_CPL; https://doi.org/10.1088/1748-0221/9/02/P02005 |
| Rights: |
© CERN 2014, published under the terms of the Creative Commons Attribution 3.0 License by IOP Publishing Ltd and Sissa Medialab srl. Any further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation and DOI. ; https://creativecommons.org/licenses/by/4.0/ ; Attribution |
| Accession Number: |
edsbas.99EF8E7D |
| Database: |
BASE |