Changes in cardiac function in patients receiving radiation therapy for lung cancer
| Title: | Changes in cardiac function in patients receiving radiation therapy for lung cancer |
|---|---|
| Authors: | Han, Ivy S; Ko, Kyunga; Zou, Jennifer Wei; Smith, Amanda M; Yegya-Raman, Nikhil; Daniels, Amber; Triolo, Carla; Xia, Congying; Mak, Raymond H; Guthier, Christian; Walls, Gerard; Robinson, Clifford; Soike, Michael; Kole, Adam J; Ohri, Nitin; Jabbour, Salma K; Di Carli, Marcelo F; Bravo, Paco; Mitchell, Joshua D; Lefebvre, Benedicte; Wilcox, Nicholas S; Wu, Kai Yi; Bradley, Jeffrey D; Feigenberg, Steven J; Ky, Bonnie |
| Source: | Han, I S, Ko, K, Zou, J W, Smith, A M, Yegya-Raman, N, Daniels, A, Triolo, C, Xia, C, Mak, R H, Guthier, C, Walls, G, Robinson, C, Soike, M, Kole, A J, Ohri, N, Jabbour, S K, Di Carli, M F, Bravo, P, Mitchell, J D, Lefebvre, B, Wilcox, N S, Wu, K Y, Bradley, J D, Feigenberg, S J & Ky, B 2026, 'Changes in cardiac function in patients receiving radiation therapy for lung cancer', Journal of Thoracic Oncology. https://doi.org/10.1016/j.jtho.2026.01.002 |
| Publication Year: | 2026 |
| Collection: | Queen's University Belfast: Research Portal |
| Subject Terms: | /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being |
| Description: | Introduction The cardiovascular toxicity of radiation therapy (RT) remains incompletely understood in patients with non-small cell lung cancer (NSCLC). Our objective was to define changes in echocardiographic parameters of structure and function with RT and their associations with cardiac dose-volume metrics. Methods This multi-center, longitudinal prospective cohort study included participants with NSCLC who received standard, curative-intent thoracic RT. Dose-volume metrics were extracted from centrally contoured cardiac substructures. Echocardiograms at baseline, end of RT, six months post-RT, and 12 months post-RT were core lab-quantified. Repeated-measures multivariable linear regression via generalized estimating equations estimated changes in echocardiographic measures and associations with dose-volume metrics. Results Across 125 participants, there was a modest worsening in left ventricular ejection fraction (LVEF) (p=0.019), global longitudinal strain (p |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1556-0864; 1556-1380 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/41534787; info:eu-repo/semantics/altIdentifier/pissn/1556-0864; info:eu-repo/semantics/altIdentifier/eissn/1556-1380 |
| DOI: | 10.1016/j.jtho.2026.01.002 |
| Availability: | https://pure.qub.ac.uk/en/publications/8ef522d6-dedd-4bd4-965b-637ceeb6c07f; https://doi.org/10.1016/j.jtho.2026.01.002; https://pureadmin.qub.ac.uk/ws/files/669002011/GERR.pdf |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.99FA589F |
| Database: | BASE |