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No increased risk of Kaposi sarcoma relapse in patients with controlled HIV‐1 infection after switching protease inhibitor‐based antiretroviral therapy

Title: No increased risk of Kaposi sarcoma relapse in patients with controlled HIV‐1 infection after switching protease inhibitor‐based antiretroviral therapy
Authors: Lajaunie, Rébecca; Cuzin, Lise; Palich, Romain; Makinson, Alain; Bani‐sadr, Firouzé; Duvivier, Claudine; Arvieux, Cedric; Rey, David; Poizot‐martin, Isabelle; Delpierre, Cyril; Delobel, Pierre; Martin‐blondel, Guillaume; Chirouze, C; Drobacheff-Thiébaut, C; Foltzer, A; Bouiller, K; Hustache-Mathieu, L; Lepiller, Q; Bozon, F; Babre, O; S Brunel, A; Muret, P; Chevalier, E; Jacomet, C; Laurichesse, H; Lesens, O; Vidal, M; Mrozek, N; Aumeran, Claire; Baud, O; Corbin, V; Goncalvez, E; Mirand, A; Brebion, A; Henquell, C; Lamaury, I; Fabre, I; Curlier, E; Ouissa, R; Herrmann-Storck, C; Tressieres, B; C Receveur, M; Boulard, F; Daniel, C; Clavel, C; M Roger, P; Markowicz, S; Chellum Rungen, N; Merrien, D; Perré, P; Guimard, T; Bollangier, O; Leautez, S; Morrier, M; Laine, L; Boucher, D; Point, P; Cotte, L; Ader, F; Becker, A; Boibieux, A; Brochier, C; Brunel-Dalmas, F; Cannesson, O; Chiarello, P; Chidiac, C; Degroodt, S; Ferry, T; Godinot, M; M Livrozet, J; Makhloufi, D; Miailhes, P; Perpoint, T; Perry, M; Pouderoux, C; Roux, S; Triffault-Fillit, C; Valour, F; Charre, C; Icard, V; C Tardy, J; a Trabaud, M; Ravaux, I; Ménard, A; y Belkhir, A; Colson, P; Dhiver, C; Madrid, A; Martin-Degioanni, M; Meddeb, L; Mokhtari, M; Motte, A; Raoux, A; Toméi, C; Tissot-Dupont, H; Poizot-Martin, I; Brégigeon, S; Zaegel-Faucher, O; Obry-Roguet, V; Laroche, H; Orticoni, M; J Soavi, M; Ressiot, E; J Ducassou, M; Jaquet, I; Galie, S; Colson, H; S Ritleng, A; Ivanova, A; Debreux, C; Lions, C; Rojas-Rojas, T; Cabié, A; Abel, S; Bavay, J; Bigeard, B; Cabras, O; Cuzin, L; Dupin de Majoubert, R; Fagour, L; Guitteaud, K; Marquise, A; Najioullah, F; Pierre-François, S; Pasquier, J; Richard, P; Rome, K; M Turmel, J; Varache, C; Atoui, N; Bistoquet, M; Delaporte, E; Le Moing, V; Makinson, A; Meftah, N; Merle de Boever, C; Montes, B; Montoya Ferrer, A; Tuaillon, E; Reynes, J; Lefèvre, B; Jeanmaire, E; Hénard, S; Frentiu, E; Charmillon, A; Legoff, A; Tissot, N; André, M; Boyer, L; P Bouillon, M; Delestan, M; Goehringer, F; Bevilacqua, S; Rabaud, C; May, T; Raffi, F; Allavena, C; Aubry, O; Billaud, E; Biron, C; Bonnet, B; Bouchez, S; Boutoille, D; Brunet-Cartier, C; Deschanvres, C; J Gaborit, B; Grégoire, A; Grégoire, M; Grossi, O; Guéry, R; Jovelin, T; Lefebvre, M; Le Turnier, P; Lecomte, R; Morineau, P; Reliquet, V; Sécher, S; Cavellec, M; Paredes, E; Soria, A; Ferré, V; André-Garnier, E; Rodallec, A; Pugliese, P; Breaud, S; Ceppi, C; Chirio, D; Cua, E; Dellamonica, P; Demonchy, E; de Monte, A; Durant, J; Etienne, C; Ferrando, S; Garraffo, R; Michelangeli, C; Mondain, V; Naqvi, A; Oran, N; Perbost, I; Carles, M; Klotz, C; Maka, A; Pradier, C; Prouvost-Keller, B; Risso, K; Rio, V; Rosenthal, E; Touitou, I; Wehrlen-Pugliese, S; Zouzou, G; Hocqueloux, L; Prazuck, T; Gubavu, C; Sève, A; Giaché, S; Rzepecki, V; Colin, M; Boulard, C; Thomas, G; Cheret, A; Goujard, C; Quertainmont, Y; Teicher, E; Lerolle, N; Jaureguiberry, S; Colarino, R; Deradji, O; Castro, A; Barrail-Tran, A; Yazdanpanah, Y; Landman, R; Joly, V; Ghosn, J; Rioux, C; Lariven, S; Gervais, A; X Lescure, F; Matheron, S; Louni, F; Julia, Z; Le Gac, S; Charpentier, C; Descamps, D; Peytavin, G; Duvivier, C; Aguilar, C; Alby-Laurent, F; Amazzough, K; Benabdelmoumen, G; Bossi, P; Cessot, G; Charlier, C; H Consigny, P; Jidar, K; Lafont, E; Lanternier, F; Leporrier, J; Lortholary, O; Louisin, C; Lourenco, J; Parize, P; Pilmis, B; Rouzaud, C; Touam, F; a Valantin, M; Tubiana, R; Agher, R; Seang, S; Schneider, L; Palich, R; Blanc, C; Katlama, C; Bani-Sadr, F; L Berger, J; N'Guyen, Y; Lambert, D; Kmiec, I; Hentzien, M; Brunet, A; Romaru, J; Marty, H; Brodard, V; Arvieux, C; Tattevin, P; Revest, M; Souala, F; Baldeyrou, M; Patrat-Delon, S; M Chapplain, J; Benezit, F; Dupont, M; Poinot, M; Maillard, A; Pronier, C; Lemaitre, F; Morlat, C; Poisson-Vannier, M; P Sinteff, J; Gagneux-Brunon, A; Botelho-Nevers, E; Frésard, A; Ronat, V; Lucht, F; Rey, D; Fischer, P; Partisani, M; Cheneau, C; Priester, M; L Batard, M; Mélounou, C; Bernard-Henry, C; de Mautort, E; Fafi-Kremer, S; Delobel, P; Alvarez, M; Biezunski, N; Debard, A; Delpierre, C; Gaube, G; Lansalot, P; Lelièvre, L; Marcel, M; Martin-Blondel, G; Piffaut, M; Porte, L; Saune, K; Robineau, O; Ajana, F; Aïssi, E; Alcaraz, I; Alidjinou, E; Baclet, V; Bocket, L; Boucher, A; Digumber, M; Huleux, T; Lafon-Desmurs, B; Meybeck, A; Pradier, M; Tetart, M; Thill, P; Viget, N; Valette, M
Contributors: Service Maladies infectieuses et tropicales CHU Toulouse; Pôle Inflammation, infection, immunologie et loco-moteur CHU Toulouse (Pôle I3LM Toulouse); Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Centre Hospitalier Universitaire de Martinique Fort-de-France, Martinique (CHU de Martinique); Equipe EQUITY (CERPOP); Centre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP); Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM); CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); Département Maladies Infectieuses et Tropicales CHRU Montpellier; Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Hôpital universitaire Robert Debré Reims (CHU Reims); Service des Maladies infectieuses et tropicales CHU Necker; Hôpital Necker - Enfants Malades AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité); Institut Cochin (IC UM3 (UMR 8104 / U1016)); Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité); Centre Médical de l'Institut Pasteur (CMIP); Institut Pasteur Paris (IP)-Université Paris Cité (UPCité); Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou; Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg); Hôpitaux Universitaires de Strasbourg (HUS); Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD); Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM); Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Laboratoire Chrono-environnement (UMR 6249) (LCE); Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC); Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC); Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon); EMERGEN consortium; Science des Procédés Céramiques et de Traitements de Surface (SPCTS); Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM); Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS); CHU Clermont-Ferrand; Service Maladies Infectieuses et Tropicales CHU Clermont-Ferrand; Pôle RHEUNNIRS CHU Clermont-Ferrand; CHU Gabriel Montpied Clermont-Ferrand; CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Gabriel Montpied Clermont-Ferrand; CHU Clermont-Ferrand-CHU Clermont-Ferrand; Queen's University Kingston, Canada; Laboratoire Microorganismes : Génome et Environnement (LMGE); Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA); Université Clermont Auvergne (UCA); Service Hygiène Hospitalière CHU Clermont-Ferrand; Centre de Coordination de la Lutte contre les Infections Nosocomiales Sud-Est (CCLIN Sud-Est); And The Dat’AIDS study group: C Chirouze, C Drobacheff-Thiébaut, A Foltzer, K Bouiller, L Hustache-Mathieu, Q Lepiller, F Bozon, O Babre, A S Brunel, P Muret, E Chevalier, C Jacomet, H Laurichesse, O Lesens, M Vidal, N Mrozek, C Aumeran, O Baud, V Corbin, E Goncalvez, A Mirand, A Brebion, C Henquell, I Lamaury, I Fabre, E Curlier, R Ouissa, C Herrmann-Storck, B Tressieres, M C Receveur, F Boulard, C Daniel, C Clavel, P M Roger, S Markowicz, N Chellum Rungen, D Merrien, P Perré, T Guimard, O Bollangier, S Leautez, M Morrier, L Laine, D Boucher, P Point, L Cotte, F Ader, A Becker, A Boibieux, C Brochier, F Brunel-Dalmas, O Cannesson, P Chiarello, C Chidiac, S Degroodt, T Ferry, M Godinot, J M Livrozet, D Makhloufi, P Miailhes, T Perpoint, M Perry, C Pouderoux, S Roux, C Triffault-Fillit, F Valour, C Charre, V Icard, J C Tardy, M A Trabaud, I Ravaux, A Ménard, A Y Belkhir, P Colson, C Dhiver, A Madrid, M Martin-Degioanni, L Meddeb, M Mokhtari, A Motte, A Raoux, C Toméi, H Tissot-Dupont, I Poizot-Martin, S Brégigeon, O Zaegel-Faucher, V Obry-Roguet, H Laroche, M Orticoni, M J Soavi, E Ressiot, M J Ducassou, I Jaquet, S Galie, H Colson, A S Ritleng, A Ivanova, C Debreux, C Lions, T Rojas-Rojas, A Cabié, S Abel, J Bavay, B Bigeard, O Cabras, L Cuzin, R Dupin de Majoubert, L Fagour, K Guitteaud, A Marquise, F Najioullah, S Pierre-François, J Pasquier, P Richard, K Rome, J M Turmel, C Varache, N Atoui, M Bistoquet, E Delaporte, V Le Moing, A Makinson, N Meftah, C Merle de Boever, B Montes, A Montoya Ferrer, E Tuaillon, J Reynes, B Lefèvre, E Jeanmaire, S Hénard, E Frentiu, A Charmillon, A Legoff, N Tissot, M André, L Boyer, M P Bouillon, M Delestan, F Goehringer, S Bevilacqua, C Rabaud, T May, F Raffi, C Allavena, O Aubry, E Billaud, C Biron, B Bonnet, S Bouchez, D Boutoille, C Brunet-Cartier, C Deschanvres, B J Gaborit, A Grégoire, M Grégoire, O Grossi, R Guéry, T Jovelin, M Lefebvre, P Le Turnier, R Lecomte, P Morineau, V Reliquet, S Sécher, M Cavellec, E Paredes, A Soria, V Ferré, E André-Garnier, A Rodallec, P Pugliese, S Breaud, C Ceppi, D Chirio, E Cua, P Dellamonica, E Demonchy, A De Monte, J Durant, C Etienne, S Ferrando, R Garraffo, C Michelangeli, V Mondain, A Naqvi, N Oran, I Perbost, M Carles, C Klotz, A Maka, C Pradier, B Prouvost-Keller, K Risso, V Rio, E Rosenthal, I Touitou, S Wehrlen-Pugliese, G Zouzou, L Hocqueloux, T Prazuck, C Gubavu, A Sève, S Giaché, V Rzepecki, M Colin, C Boulard, G Thomas, A Cheret, C Goujard, Y Quertainmont, E Teicher, N Lerolle, S Jaureguiberry, R Colarino, O Deradji, A Castro, A Barrail-Tran, Y Yazdanpanah, R Landman, V Joly, J Ghosn, C Rioux, S Lariven, A Gervais, F X Lescure, S Matheron, F Louni, Z Julia, S Le Gac, C Charpentier, D Descamps, G Peytavin, C Duvivier, C Aguilar, F Alby-Laurent, K Amazzough, G Benabdelmoumen, P Bossi, G Cessot, C Charlier, P H Consigny, K Jidar, E Lafont, F Lanternier, J Leporrier, O Lortholary, C Louisin, J Lourenco, P Parize, B Pilmis, C Rouzaud, F Touam, M A Valantin, R Tubiana, R Agher, S Seang, L Schneider, R Palich, C Blanc, C Katlama, F Bani-Sadr, J L Berger, Y N'Guyen, D Lambert, I Kmiec, M Hentzien, A Brunet, J Romaru, H Marty, V Brodard, C Arvieux, P Tattevin, M Revest, F Souala, M Baldeyrou, S Patrat-Delon, J M Chapplain, F Benezit, M Dupont, M Poinot, A Maillard, C Pronier, F Lemaitre, C Morlat, M Poisson-Vannier, T Jovelin, J P Sinteff, A Gagneux-Brunon, E Botelho-Nevers, A Frésard, V Ronat, F Lucht, D Rey, P Fischer, M Partisani, C Cheneau, M Priester, M L Batard, C Mélounou, C Bernard-Henry, E de Mautort, S Fafi-Kremer, P Delobel, M Alvarez, N Biezunski, A Debard, C Delpierre, G Gaube, P Lansalot, L Lelièvre, M Marcel, G Martin-Blondel, M Piffaut, L Porte, K Saune, O Robineau, F Ajana, E Aïssi, I Alcaraz, E Alidjinou, V Baclet, L Bocket, A Boucher, M Digumber, T Huleux, B Lafon-Desmurs, A Meybeck, M Pradier, M Tetart, P Thill, N Viget, M Valette
Source: ISSN: 1464-2662.
Publisher Information: CCSD; Wiley
Publication Year: 2022
Collection: Université de Franche-Comté (UFC): HAL
Subject Terms: AIDS; HHV8; Kaposi sarcoma; antiretroviral therapy; protease inhibitors; switch; MESH: CD4 Lymphocyte Count; MESH: HIV Infections* / complications; MESH: HIV Infections* / drug therapy; MESH: HIV-1; MESH: Humans; MESH: Neoplasm Recurrence; Local / complications; MESH: Protease Inhibitors / adverse effects; MESH: Retrospective Studies; MESH: Sarcoma; Kaposi* / drug therapy; MESH: Viral Load; [SDV]Life Sciences [q-bio]
Description: International audience ; Objectives: Our aim was to assess if switching from a protease inhibitors (PI)-based regimen to a PI-free one is associated with an increased risk of Kaposi Sarcoma (KS) relapse among patients living with HIV (PLHIV) with history of KS and controlled HIV replication.Methods: In a retrospective analysis of the prospectively collected Dat'AIDS database we selected patients who both had a past KS history and a HIV-1 viral load below 200 copies/mL while being PI-treated. We searched for KS relapses while persistent virological success was maintained for at least 6 months, whether patients kept taking the PI, or switched to PI-free regimen.Results: Among the 216 patients with past KS event and a history of HIV-1 infection efficiently treated by a PI-based regimen, 148 patients (68.5%) later switched to a PI-sparing regimen. Their baseline characteristics were not different from non-switching patients. We described 7 cases of relapse (3.2% of the 216 patients). Five cases of relapse occurred in switching patients (3.4%). The remaining two relapses occurred in PI-treated patients (2.9%). At KS relapse, CD4 cell count was 459 cells/μL (range 225-560) for switching patients, compared with 362 and 136 cells/μL for the other two patients.Conclusions: In this large cohort of PLHIV with a history of KS and ART-controlled HIV replication, KS relapses were described in 3.2% of the patients, and were not more frequent when a PI-containing ART regimen has been switched to a PI-free regimen. Our results do not support a specific effect of PI on KS.
Document Type: article in journal/newspaper
Language: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/34668293; PUBMED: 34668293
DOI: 10.1111/hiv.13168
Availability: https://inserm.hal.science/inserm-03651227; https://inserm.hal.science/inserm-03651227v1/document; https://inserm.hal.science/inserm-03651227v1/file/HIVMedicine_2022.pdf; https://doi.org/10.1111/hiv.13168
Rights: https://about.hal.science/hal-authorisation-v1/
Accession Number: edsbas.9A169304
Database: BASE