| Title: |
2302. Transmissibility of SARS-CoV-2 by symptom: data from a case-ascertained household transmission study |
| Authors: |
Mellis, Alexandra; Smith-Jeffcoat, Sarah E; Petrie, Joshua; Keipp Talbot, H; Morrissey, Kerry Grace; Stockwell, Melissa; Maldonado, Yvonne A; Bowman, Natalie M; Lutrick, Karen; Rao, Suchitra; Salvatore, Phillip P; Biddle, Jessica E; Olivo, Vanessa; Battan-Wraith, Steph; Merrill, Lori S; McLaren, Son H; Sano, Ellen; Diaz, Anny; Sarnquist, Clea; Govindaranjan, Prasanthi; Goodman, Sara H; Ellingson, Katherine; Ledezma, Karla I; Pryor, Kathleen; Lin, Jessica T; Bullock, Ayla; Yang, Amy; Belongia, Edward; McLean, Huong; Asturias, Edwin J; Izurieta, Hector; Hart, Kimberly W; Schmitz, Jonathan; Zhu, Yuwei; Rolfes, Melissa A; Grijalva, Carlos G |
| Source: |
Open Forum Infectious Diseases ; volume 10, issue Supplement_2 ; ISSN 2328-8957 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2023 |
| Description: |
Background Understanding the transmissibility of respiratory viruses by symptoms is important for public health. Methods Persons who tested positive for SARS-CoV-2 and their household contacts (HHC) were recruited from 7 US sentinel sites or by remote invitation nationwide during Sep. 2021—Mar. 2023. The household primary case was the person with the earliest symptom onset or positive test. Starting ≤6 days after primary case onset, primary cases and HHC completed symptom logs (daily, retrospective since onset and for 10 days post-enrollment) and collected nasal or saliva specimens (daily for 10 days) that were tested by RT-PCR. Infected individuals were counted as having developed fever, lower respiratory symptoms (LRS: wheezing, chest tightness/pain, shortness of breath, cough), other symptoms (fatigue, aches, abdominal pain, diarrhea, vomiting, change of taste/smell, headache, sore throat, runny nose, nasal congestion), or as being asymptomatic based on all logs. Risk of secondary infection (any PCR positivity) among eligible, tested HHC (Methods 1) by symptoms of primary cases was estimated using Poisson regression with generalized estimating equations. We estimated days from onset to last PCR positive in a survival model. Methods upload 1. Enrolled and analytically included household members in case-ascertained studies of household transmission of SARS-CoV-2, United States, Sept 2021 - Mar 2023. Results This analysis included 842 households (839 primary cases, 836 infected HHC, and 615 uninfected HHC, median household size of 2). Most primary cases (99%) and infected HHC (81%) were symptomatic (Results 1). Primary cases had higher frequencies of fever or LRS than infected HHC (Results 2). HHC exposed to primary cases who developed fever or LRS were more likely to become infected than HHC exposed to primary cases who did not have fever or LRS (Results 3). Post-hoc comparisons by individual symptoms supported this for fever and all LRS but chest pain (fever: IRR 1.31 95% CI: 1.13-1.52; cough: IRR ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ofid/ofad500.1924 |
| Availability: |
https://doi.org/10.1093/ofid/ofad500.1924; https://academic.oup.com/ofid/article-pdf/10/Supplement_2/ofad500.1924/53765717/ofad500.1924.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.9A348B96 |
| Database: |
BASE |