| Title: |
Impact of minimal residual disease on the outcome of hematopoietic stem cell transplantation for childhood acute lymphoblastic leukemia within the FORUM Trial |
| Authors: |
Balduzzi, Adriana; Glogova, Evgenia; Peters, Christina; Sedlacek, Petr; Dalle, Jean-Hugues; Locatelli, Franco; Meisel, Roland; Burkhardt, Birgit; Buechner, Jochen; Wachowiak, Jacek; Bierings, Marc; Staciuk, Raquel; Graphakos, Stelios; Güngör, Tayfun; Yesilipek, Akif; Svec, Peter; Palma, Julia; Krivan, Gergely; Diaz-de-Heredia, Cristina; Limido, Francesca; Ansari, Marc; Kalwak, Krzysztof; Bader, Peter; Ifversen, Marianne |
| Contributors: |
Balduzzi, A; Glogova, E; Peters, C; Sedlacek, P; Dalle, J; Locatelli, F; Meisel, R; Burkhardt, B; Buechner, J; Wachowiak, J; Bierings, M; Staciuk, R; Graphakos, S; Güngör, T; Yesilipek, A; Svec, P; Palma, J; Krivan, G; Diaz-de-Heredia, C; Limido, F; Ansari, M; Kalwak, K; Bader, P; Ifversen, M |
| Publisher Information: |
Ferrata Storti Foundation; IT |
| Publication Year: |
2026 |
| Collection: |
Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| Subject Terms: |
minimal residual disease; hematopoietic stem cell transplantation; childhood; acute lymphoblastic leukemia; FORUM Trial |
| Description: |
In the randomized cohort of the international phase-III FORUM trial, which showed the superiority of total-body irradiation (TBI) over chemotherapy-based conditioning prior to hematopoietic stem cell transplantation (HSCT) for pediatric acute lymphoblastic leukemia (ALL), type of conditioning and remission phase, but not pre-HSCT minimal residual disease (MRD), were associated with outcome. We report the impact of MRD within the extended FORUM cohort. Patients (N=1,014) aged 4-21 years old, transplanted from a matched donor who had ≥1 MRD measurement prior to and/or 100 days and/or one year after HSCT were eligible. A threshold of 0.01% defined MRD positivity versus negativity. Prior to HSCT, 21% of patients were MRDpos. Three-year event-free survival (EFS) was 0.73 and 0.59 (P |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40820816; info:eu-repo/semantics/altIdentifier/wos/WOS:001660777000013; volume:111; issue:1 (January, 2026); firstpage:122; lastpage:134; numberofpages:13; journal:HAEMATOLOGICA; https://hdl.handle.net/10281/569005 |
| DOI: |
10.3324/haematol.2025.287456 |
| Availability: |
https://hdl.handle.net/10281/569005; https://doi.org/10.3324/haematol.2025.287456 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative Commons ; license uri:http://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: |
edsbas.9A354DE9 |
| Database: |
BASE |