| Title: |
Distinct Inflammatory Phenotypes Are Associated With Subclinical and Clinical Cardiovascular Disease in People With Human Immunodeficiency Virus |
| Authors: |
McGettrick, Padraig; Tinago, Willard; O’Brien, Julie; Miles, Sarah; Lawler, Leo; Garcia-Leon, Alejandro; Mahon, Niall; Lambert, John; Sheehan, Gerard; Landay, Alan; Sabin, Caroline A; Cotter, Aoife G; Mallon, Patrick W G; McGettrick, P; Alvarez Barco, E; Tinago, W; Garcia-Leon, A; McDermott, A; McGinty, T; Cotter, A G; Macken, A; Mallon, P W G; Kavanagh, E; McCarthy, G; Sheehan, G; Lambert, J; Powderly, W; Compston, J; Sabin, C; Cotter, A; Muldoon, E; Lambert, J S; Green, S; Leamy, K; Kenny, G; McCann, K; McCann, R; O’Broin, C; Waqas, S; Savinelli, S; Feeney, E; Garcia Leon, A; Miles, S; Alalwan, D; Negi, R; de Barra, E; McConkey, S |
| Contributors: |
Irish Health Research Board |
| Source: |
The Journal of Infectious Diseases ; volume 230, issue 3, page e616-e621 ; ISSN 0022-1899 1537-6613 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2024 |
| Description: |
Despite inflammation being implicated in cardiovascular disease (CVD) in people with human immunodeficiency virus (PWH), considerable heterogeneity within populations of PWH exists. Stratifying CVD risk based on inflammatory phenotype could play an important role. Using principal component analyses and unsupervised hierarchical clustering, we examined 38 biomarkers to identify inflammatory phenotypes in 2 independent cohorts of PWH. We identified 3 distinct inflammatory clusters present in both cohorts that were associated with altered risk of both subclinical CVD (cohort 1) and prevalent clinical CVD (cohort 2) after adjusting for CVD risk factors. These data support precision medicine approaches to enhance CVD risk assessment in PWH. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/infdis/jiae007 |
| DOI: |
10.1093/infdis/jiae007/56717621/jiae007.pdf |
| Availability: |
https://doi.org/10.1093/infdis/jiae007; https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiae007/56717621/jiae007.pdf; https://academic.oup.com/jid/article-pdf/230/3/e616/59248564/jiae007.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.9A70362C |
| Database: |
BASE |