| Title: |
High anti-SARS-CoV-2 antibody seroconversion rates before the second wave in Manaus, Brazil, and the protective effect of social behaviour measures: results from the prospective DETECTCoV-19 cohort |
| Authors: |
Lalwani, Pritesh; Araujo-Castillo, Roger V.; Ganoza, Christian A.; Salgado, Bárbara Batista; Pereira Filho, Ivanildo Vieira; da Silva, Danielle Severino Sena; de Morais, Thiago Barros do Nascimento; Jordão, Maele Ferreira; Ortiz, Jessica Vanina; Barbosa, Aguyda Rayany Cavalcante; Sobrinho, Wlademir Braga Salgado; Cordeiro, Isabelle Bezerra; de Souza Neto, Júlio Nino; de Assunção, Enedina Nogueira; da Costa, Cristiano Fernandes; de Souza, Pedro Elias; de Albuquerque, Bernardino Claudio; Astofi-Filho, Spartaco; Holanda, Aldina Iacy Paulain; Gomes, Ana Lúcia Silva; França, Ana Paula Souza de; Monteiro, André Victor Rabelo; Santos, Andressa dos Passos; Teixeira, Antônia de Sousa; Souza, Antônio Vinicius Soares de; Pinheiro, Beatriz; Santos, Bianca Pires dos; Farias, Brenda Pereira; Paulino, Bruno Nicolau; Silva, Caio Lúcio Andreola da; Oliveira, Cinthya Iamile Frithz Brandão de; Martins, Dalila de Alcântara; Oliveira, Eline Araújo de; Carvalho, Elisson Denny da Costa; Costa, Evillyn Fernandes Da; Simplicio, Fernanda Guilhon; Pereira, Fernanda Serrão; Sinimbu, Gabriele Pimentel; Cardenes, Genilton de Oliveira; Silva, Giane Alves da; Costa, Iago Sampaio Fernandes da; Correia, Ingrid Silva; Santos, Ilia Gilmara Carvalho dos; Guimarães, Jackeline Vieira; Pinheiro, Jessica Samile Batista; Romana, Juliana Correa; França, Josineide de Oliveira Novo; Pinto, Kerollen Runa; Freitas, Maria Fiamma Farias; Vasconcellos, Marne Carvalho de; Moraes, Marizete Candido; Damasceno, Matheus da Silva; Ruiz, Michelle Araújo; Lemos, Milena Maria Cardoso de; Picanço, Neila Soares; Maia, Rayara Gonzaga; Bezerra, Regiane Carneiro; Souza, Romeu Santos de; Harjani, Susy Cavalcante; Souza, Vitor Batista de; Melo, Wellington Barbosa de; Lalwani, Jaila Dias Borges |
| Source: |
Universidad Peruana de Ciencias Aplicadas (UPC) ; Repositorio Academico - UPC ; The Lancet Global Health ; 9 ; 11 ; e1508 ; e1516 |
| Publisher Information: |
Elsevier Ltd |
| Publication Year: |
2021 |
| Collection: |
Repositorio Académico de la Universidad Peruana de Ciencias Aplicadas (UPC) |
| Subject Terms: |
COVID-19; Epidemics; Female; Immunoglobulin G; Prospective Studies; https://purl.org/pe-repo/ocde/ford#3.00.00 |
| Description: |
Background: The city of Manaus, Brazil, has seen two collapses of the health system due to the COVID-19 pandemic. We report anti-SARS-CoV-2 nucleocapsid IgG antibody seroconversion rates and associated risk factors in Manaus residents before the second wave of the epidemic in Brazil. Methods: A convenience sample of adult (aged ≥18 years) residents of Manaus was recruited through online and university website advertising into the DETECTCoV-19 study cohort. The current analysis of seroconversion included a subgroup of DETECTCoV-19 participants who had at least two serum sample collections separated by at least 4 weeks between Aug 19 and Oct 2, 2020 (visit 1), and Oct 19 and Nov 27, 2020 (visit 2). Those who reported (or had no data on) having a COVID-19 diagnosis before visit 1, and who were positive for anti-SARS-CoV-2 nucleocapsid IgG antibodies at visit 1 were excluded. Using an in-house ELISA, the reactivity index (RI; calculated as the optical density ratio of the sample to the negative control) for serum anti-SARS-CoV-2 nucleocapsid IgG antibodies was measured at both visits. We calculated the incidence of seroconversion (defined as RI values ≤1·5 at visit 1 and ≥1·5 at visit 2, and a ratio >2 between the visit 2 and visit 1 RI values) during the study period, as well as incidence rate ratios (IRRs) through cluster-corrected and adjusted Poisson regression models to analyse associations between seroconversion and variables related to sociodemographic characteristics, health access, comorbidities, COVID-19 exposure, protective behaviours, and symptoms. Findings: 2496 DETECTCoV-19 cohort participants returned for a follow-up visit between Oct 19 and Nov 27, 2020, of whom 204 reported having COVID-19 before the first visit and 24 had no data regarding previous disease status. 559 participants were seropositive for anti-SARS-CoV-2 nucleocapsid IgG antibodies at baseline. Of the remaining 1709 participants who were seronegative at baseline, 71 did not meet the criteria for seroconversion and were excluded ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
2214109X |
| Relation: |
https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(21)00355-7/fulltext; https://hdl.handle.net/10757/658416; The Lancet Global Health; SCOPUS_ID:85117180231; S2214109X21003557; 0000 0001 2196 144X |
| DOI: |
10.1016/S2214-109X(21)00355-7 |
| Availability: |
https://hdl.handle.net/10757/658416; https://doi.org/10.1016/S2214-109X(21)00355-7 |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-sa/4.0/ |
| Accession Number: |
edsbas.9A8A6889 |
| Database: |
BASE |