| Title: |
Impact of high-dose vitamin D and calcium carbonate supplementation on bone density in adolescents living with HIV: a randomised, placebo-controlled trial |
| Authors: |
Ferrand, Rashida A; Dzavakwa, Nyasha V; Bandason, Tsitsi; Chisenga, Molly; Filteau, Suzanne; Kranzer, Katharina; Banda Mabuda, Hildah; Mchugh, Grace; Mujuru, Hilda; Redzo, Nicol; Rowland-Jones, Sarah L; Schaible, Ulrich E; Simms, Victoria; Tang, Jonathan C Y; Kasonka, Lackson; Gregson, Celia L |
| Source: |
Ferrand, R A, Dzavakwa, N V, Bandason, T, Chisenga, M, Filteau, S, Kranzer, K, Banda Mabuda, H, Mchugh, G, Mujuru, H, Redzo, N, Rowland-Jones, S L, Schaible, U E, Simms, V, Tang, J C Y, Kasonka, L, Gregson, C L 2026, 'Impact of high-dose vitamin D and calcium carbonate supplementation on bone density in adolescents living with HIV: a randomised, placebo-controlled trial', Lancet Child and Adolescent Health, vol. 10, no. 2, pp. 111-121. https://doi.org/10.1016/S2352-4642(25)00301-3 |
| Publication Year: |
2026 |
| Collection: |
University of Bristol: Bristol Reserach |
| Subject Terms: |
Humans; Adolescent; Female; Male; Bone Density/drug effects; HIV Infections/drug therapy; Child; Double-Blind Method; Calcium Carbonate/administration & dosage; Dietary Supplements; Young Adult; Vitamin D/administration & dosage; Cholecalciferol/administration & dosage; Absorptiometry; Photon; Zambia; Zimbabwe |
| Description: |
Background : HIV has adverse impact on skeletal development in children despite antiretroviral therapy (ART). We investigated the effect of high-dose (20 000 IU) weekly vitamin D3 and daily calcium carbonate (500 mg) supplementation for 48 weeks on bone density and muscle strength and power among peripubertal individuals (11–19 years) with perinatally acquired HIV. Methods : We conducted an individually randomised, double-blind, placebo-controlled trial. Individuals taking ART for at least 6 months who had a defined caregiver, and knew their HIV status (in those aged >12 years) were recruited from HIV clinics in Harare, Zimbabwe and Lusaka, Zambia. The primary outcome was total body less-head bone mineral density (TBLH-BMD) Z score and secondary outcome was lumbar spine bone mineral apparent density (LS-BMAD) Z score (both measured by dual-energy x-ray absorptiometry). Linear regression was used to compare arms adjusting for country and baseline value of the measure. Pre-specified subgroup analyses by country, age-group, sex, pubertal stage, calcium intake, tenofovir disproxil fumarate use, and baseline vitamin D insufficiency (defined as 25[OH]D |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41391456; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/1983/a353f623-e7c2-408a-9a2b-5deb6edd6a58 |
| DOI: |
10.1016/S2352-4642(25)00301-3 |
| Availability: |
https://hdl.handle.net/1983/a353f623-e7c2-408a-9a2b-5deb6edd6a58; https://research-information.bris.ac.uk/en/publications/a353f623-e7c2-408a-9a2b-5deb6edd6a58; https://doi.org/10.1016/S2352-4642(25)00301-3 |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.9AC3014B |
| Database: |
BASE |