| Title: |
Reperfused Myocardial Infarction: The Road to CCS Classification of Acute MI and Beyond |
| Authors: |
Dharmakumar, Rohan; Kloner, Robert A.; Fishbein, Michael; Heusch, Gerd; Vora, Keyur P.; Gropler, Robert; Henry, Timothy; Shing-Chan, Fai; Singh, Dhirendra; Jambunathan, Nithya; Subramanian, Ramesh; Kreutz, Rolf P.; Reed, Grant W.; Kovacs, Richard J.; Fry, Edward; Kalra, Ankur; Kumar, Andreas; Raman, Subha V. |
| Contributors: |
Medicine, School of Medicine |
| Source: |
PMC |
| Publisher Information: |
Elsevier |
| Publication Year: |
2025 |
| Collection: |
Indiana University - Purdue University Indianapolis: IUPUI Scholar Works |
| Subject Terms: |
CCS stages of myocardial tissue injury; Intramyocardial hemorrhage; Myocardial infarction; Reperfusion injury; Reperfusion therapy |
| Description: |
The Canadian Cardiovascular Society recently put forth a new classification of acute reperfused myocardial infarction (MI) based on stages of myocardial injury. Backed by more than 5 decades of intense investigation in the field, the key message of this new classification is that not all MIs are the same and that the type and extent of myocardial injury should be considered in diagnosing and treating MI. We review the literature with the goal of highlighting the progressive advances that enabled the synthesis of the Canadian Cardiovascular Society classification into 4 distinct stages of tissue injury. We emphasize the major breakthroughs from insights gained from experimental, translational, and clinical studies to date. We also identify current gaps in knowledge and critical research directions that need to be pursued to improve patient care and reduce post-MI complications such as chronic heart failure and malignant arrhythmias, whose risk is linked to stage and extent of myocardial injury. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
JACC: Advances; Dharmakumar R, Kloner RA, Fishbein M, et al. Reperfused Myocardial Infarction: The Road to CCS Classification of Acute MI and Beyond. JACC Adv. 2025;4(2):101528. doi:10.1016/j.jacadv.2024.101528; https://hdl.handle.net/1805/47109 |
| Availability: |
https://hdl.handle.net/1805/47109 |
| Rights: |
Attribution-NonCommercial-NoDerivatives 4.0 International ; https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.9AFDA263 |
| Database: |
BASE |