| Title: |
Evaluation of correlations between genetic variants and high-resolution computed tomography patterns in idiopathic pulmonary fibrosis |
| Authors: |
Baratella E.; Ruaro B.; Giudici F.; Wade B.; Santagiuliana M.; Salton F.; Confalonieri P.; Simbolo M.; Scarpa A.; Tollot S.; Marrocchio C.; Cova M. A.; Confalonieri M. |
| Contributors: |
Baratella, E.; Ruaro, B.; Giudici, F.; Wade, B.; Santagiuliana, M.; Salton, F.; Confalonieri, P.; Simbolo, M.; Scarpa, A.; Tollot, S.; Marrocchio, C.; Cova, M. A.; Confalonieri, M. |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2021 |
| Collection: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Subject Terms: |
Familial idiopathic pulmonary fibrosi; High-resolution computed tomog-raphy (HRCT); Idiopathic pulmonary fibrosi; Interstitial lung disease |
| Description: |
Background. Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease (ILD). This prospective observational study aimed at the evaluation of any correlation between genetic variants associated with IPF susceptibility and high-resolution computed tomog-raphy (HRCT) patterns. It also aimed at evidencing any differences in the HRTC pattern between the familial and sporadic form at diagnosis and after two years. Methods. A total of 65 IPF patients (mean age at diagnosis 65 ± 10) were enrolled after having given written informed consent. HRCT and genetic evaluations were performed. Results. A total of 19 familial (mean age 62 ± 15) and 46 sporadic (mean age 70 ± 9) IPF patients were enrolled. A statistically significant difference was evidenced in the HRTC pattern at diagnosis between the two groups. Sporadic IPF patients had a predominantly usual interstitial pneumonia (UIP) pattern compared with those patients with familial IPF (60.0% vs. 21.1%, respectively). Moreover, familial IPF patients had more alternative diagnoses than those with sporadic IPF (31.6% vs. 2.2%, respectively). Furthermore, there was a slight increase in the typical UIP pattern in the familial IPF group at two years from diagnosis. Conclusions. Genetic factors play a pivotal role in the risk of developing IPF. However, further studies are required to clarify how these genetic factors may guide clinical treatment decisions. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/33922858; info:eu-repo/semantics/altIdentifier/wos/WOS:000653845700001; volume:11; issue:5; firstpage:762; journal:DIAGNOSTICS; https://hdl.handle.net/11577/3401285 |
| DOI: |
10.3390/diagnostics11050762 |
| Availability: |
https://hdl.handle.net/11577/3401285; https://doi.org/10.3390/diagnostics11050762 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.9B093625 |
| Database: |
BASE |