| Title: |
Prognostication algorithm for non-cirrhotic non-B non-C hepatocellular carcinoma—a multicenter study under the aegis of the French Association of Hepato-Biliary Surgery and liver Transplantation |
| Authors: |
Maulat, Charlotte; Truant, Stéphanie; Hobeika, Christian; Barbier, Louise; Herrero, Astrid; Doussot, Alexandre; Gagnière, Johan; Girard, Édouard; Tranchart, Hadrien; Regimbeau, Jean-Marc; Fuks, David; Cauchy, François; Prodeau, Mathieu; Notte, Antoine; Toubert, Cyprien; Salamé, Ephrem; El Amrani, Mehdi; Andrieu, Sandrine; Muscari, Fabrice; Shourick, Jason; Suc, Bertrand |
| Contributors: |
Service Chirurgie viscérale et digestive CHU Toulouse; Pôle Maladies de l'appareil digestif CHU Toulouse; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 (CANTHER); Institut Pasteur de Lille; Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS); Université Paris Cité (UPCité); Hôpital Beaujon AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Centre Hospitalier Régional Universitaire de Tours (CHRU Tours); Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon); Service Chirurgie Digestive et Hépatobiliaire CHU Clermont-Ferrand; CHU Estaing Clermont-Ferrand; CHU Clermont-Ferrand-CHU Clermont-Ferrand-Pôle Spécialités médicales et chirurgicales CHU Clermont-Ferrand; CHU Clermont-Ferrand; CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble (CHUGA); Université Paris-Sud - Paris 11 - Faculté de médecine (UP11 UFR Médecine); Université Paris-Sud - Paris 11 (UP11); AP-HP - Hôpital Antoine Béclère Clamart; CHU Amiens-Picardie; Simplification des soins chez les patients complexes - UR UPJV 7518 (SSPC); Université de Picardie Jules Verne (UPJV); Institut Mutualiste de Montsouris (IMM); Service de Chirurgie Digestive CHRU Besançon; Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC); Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC); Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse; AP-HP. Université Paris Saclay-AP-HP. Université Paris Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Centre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP); Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Source: |
ISSN: 2304-3881. |
| Publisher Information: |
CCSD; AME Publishing Company |
| Publication Year: |
2023 |
| Collection: |
Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| Subject Terms: |
Hepatocellular carcinoma (HCC); non-cirrhotic liver; prognostic factors; prognostication algorithm; recurrence-free survival (RFS); [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Description: |
International audience ; Background: Liver resection and local ablation are the only curative treatment for non-cirrhotic hepatocellular carcinoma (HCC). Few data exist concerning the prognosis of patients resected for non-cirrhotic HCC. The objectives of this study were to determine the prognostic factors of recurrence-free survival (RFS) and overall survival (OS) and to develop a prognostication algorithm for non-cirrhotic HCC.Methods: French multicenter retrospective study including HCC patients with non-cirrhotic liver without underlying viral hepatitis: F0, F1 or F2 fibrosis.Results: A total of 467 patients were included in 11 centers from 2010 to 2018. Non-cirrhotic liver had a fibrosis score of F0 (n=237, 50.7%), F1 (n=127, 27.2%) or F2 (n=103, 22.1%). OS and RFS at 5 years were 59.2% and 34.5%, respectively. In multivariate analysis, microvascular invasion and HCC differentiation were prognostic factors of OS and RFS and the number and size were prognostic factors of RFS (P2 HCC regardless of size (n=20, Group 3). The 5-year RFS rates were 52.7% (Group 1), 30.1% (Group 2) and 5% (Group 3).Conclusions: We developed a prognostication algorithm based on the number (≤ or >2) and size (≤ or >10 cm), which could be used as a treatment decision support concerning the need for perioperative therapy. In case of bifocal HCC, surgery should not be a contraindication. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/37124677; PUBMED: 37124677; PUBMEDCENTRAL: PMC10129883 |
| DOI: |
10.21037/hbsn-22-33 |
| Availability: |
https://u-picardie.hal.science/hal-04089016; https://u-picardie.hal.science/hal-04089016v1/document; https://u-picardie.hal.science/hal-04089016v1/file/Maulat_2023.pdf; https://doi.org/10.21037/hbsn-22-33 |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.9B0964D0 |
| Database: |
BASE |