| Title: |
Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection |
| Authors: |
Feng, Shuo; Phillips, Daniel J.; White, Thomas; Sayal, Homesh; Aley, Parvinder K.; Bibi, Sagida; Dold, Christina; Fuskova, Michelle; Gilbert, Sarah C.; Hirsch, Ian; Humphries, Holly E.; Jepson, Brett; Kelly, Elizabeth J.; Plested, Emma; Shoemaker, Kathryn; Thomas, Kelly M.; Vekemans, Johan; Villafana, Tonya L.; Lambe, Teresa; Pollard, Andrew J.; Voysey, Merryn; Adlou, Syed; Allen, Lauren; Angus, Brian; Anslow, Rachel; Asselin, Marie Claude; Baker, Natalie; Baker, Philip; Barlow, Thomas; Beveridge, Amy; Bewley, Kevin R.; Brown, Phillip; Brunt, Emily; Buttigieg, Karen R.; Camara, Susana; Charlton, Sue; Chiplin, Emily; Cicconi, Paola; Clutterbuck, Elizabeth A.; Collins, Andrea M.; Coombes, Naomi S.; Clemens, Sue Ann Costa; Davison, Melanie; Demissie, Tesfaye; Dinesh, Tanya; Douglas, Alexander D.; Duncan, Christopher J.A.; Emary, Katherine R.W.; Ewer, Katie J.; Felle, Sally; Ferreira, Daniela M.; Finn, Adam; Folegatti, Pedro M.; Fothergill, Ross; Fraser, Sara; Garlant, Harriet; Gatcombe, Laura; Godwin, Kerry J.; Goodman, Anna L.; Green, Christopher A.; Hallis, Bassam; Hart, Thomas C.; Heath, Paul T.; Hill, Helen; Hill, Adrian V.S.; Jenkin, Daniel; Kasanyinga, Mwila; Kerridge, Simon; Knight, Chanice; Leung, Stephanie; Libri, Vincenzo; Lillie, Patrick J.; Marinou, Spyridoula; McGlashan, Joanna; McGregor, Alastair C.; McInroy, Lorna; Minassian, Angela M.; Mujadidi, Yama F.; Penn, Elizabeth J.; Petropoulos, Christos J.; Pollock, Katrina M.; Proud, Pamela C.; Provstgaard-Morys, Samuel; Rajapaska, Durga; Ramasamy, Maheshi N.; Sanders, Katherine; Shaik, Imam; Singh, Nisha; Smith, Andrew; Snape, Matthew D.; Song, Rinn; Shrestha, Sonu; Sutherland, Rebecca K.; Thomson, Emma C.; Turner, David P.J.; Webb-Bridges, Alice; Wrin, Terri; Williams, Christopher J. |
| Publisher Information: |
Nature Publishing Group |
| Publication Year: |
2021 |
| Collection: |
University of Nottingham: Repository@Nottingham |
| Description: |
The global supply of COVID-19 vaccines remains limited. An understanding of the immune response that is predictive of protection could facilitate rapid licensure of new vaccines. Data from a randomized efficacy trial of the ChAdOx1 nCoV-19 (AZD1222) vaccine in the United Kingdom was analyzed to determine the antibody levels associated with protection against SARS-CoV-2. Binding and neutralizing antibodies at 28 days after the second dose were measured in infected and noninfected vaccine recipients. Higher levels of all immune markers were correlated with a reduced risk of symptomatic infection. A vaccine efficacy of 80% against symptomatic infection with majority Alpha (B.1.1.7) variant of SARS-CoV-2 was achieved with 264 (95% CI: 108, 806) binding antibody units (BAU)/ml: and 506 (95% CI: 135, not computed (beyond data range) (NC)) BAU/ml for anti-spike and anti-RBD antibodies, and 26 (95% CI: NC, NC) international unit (IU)/ml and 247 (95% CI: 101, NC) normalized neutralization titers (NF50) for pseudovirus and live-virus neutralization, respectively. Immune markers were not correlated with asymptomatic infections at the 5% significance level. These data can be used to bridge to new populations using validated assays, and allow extrapolation of efficacy estimates to new COVID-19 vaccines. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://nottingham-repository.worktribe.com/output/6511813; Nature Medicine; Volume 27; Issue 11; Pagination 2032-2040 |
| DOI: |
10.1038/s41591-021-01540-1 |
| Availability: |
https://doi.org/10.1038/s41591-021-01540-1; https://nottingham-repository.worktribe.com/file/6511813/1/Correlates%20of%20protection%20against%20symptomatic%20and%20asymptomatic%20SARS-CoV-2%20infection; https://nottingham-repository.worktribe.com/output/6511813 |
| Rights: |
openAccess ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.9B1CFB0D |
| Database: |
BASE |