| Title: |
INFLUENCE OF MATERNAL HYPERTYROIDISM ON POSTNATAL MORPHOGENESIS OF PROGENY TESTES AS DETECTED BY MORPHOMETRIC AND LECTIN HISTOCHEMISTRY METHODS ; ВЛИЯНИЕ ЭКСПЕРИМЕНТАЛЬНОГО ГИПЕРТИРЕОЗА МАТЕРИНСКОГО ОРГАНИЗМА НА ПОСТНАТАЛЬНЫЙ МОРФОГЕНЕЗ ЯИЧЕК ПОТОМСТВА ПО ДАННЫМ МОРФОМЕТРИИ И ЛЕКТИНОВОЙ ГИСТОХИМИИ ; ВПЛИВ ЕКСПЕРИМЕНТАЛЬНОГО ГІПЕРТИРЕОЗУ МАТЕРИНСЬКОГО ОРГАНІЗМУ НА ПОСТНАТАЛЬНИЙ МОРФОГЕНЕЗ ЯЄЧОК ПОТОМСТВА ЗА ДАНИМИ МОРФОМЕТРІЇ ТА ЛЕКТИНОВОЇ ГІСТОХІМІЇ |
| Authors: |
Shegedin, A. Yu.; Strus, Kh. I.; Yashchenko, A. M. |
| Source: |
Achievements of Clinical and Experimental Medicine; No. 3 (2019); 157-165 ; Достижения клинической и экспериментальной медицины; № 3 (2019); 157-165 ; Здобутки клінічної і експериментальної медицини; № 3 (2019); 157-165 ; 2415-8836 ; 1811-2471 ; 10.11603/1811-2471.2019.v.i3 |
| Publisher Information: |
Тернопільський державний медичний університет |
| Publication Year: |
2020 |
| Collection: |
I. Horbachevsky Ternopil State Medical University: DSpace Repository / ТЕРНОПІЛЬСЬКИЙ ДЕРЖАВНИЙ МЕДИЧНИЙ УНІВЕРСИТЕТ імені І.Я. Горбачевськог (ТДМУ) |
| Subject Terms: |
rats; maternal hyperthyroidism; progeny testes morphogenesis; morphometry; lectin histochemistry; крысы; гипертиреоз материнского организма; морфогенез яичек потомства; морфометрия; лектиновая гистохимия; щури; гіпертиреоз материнського організму; морфогенез яєчок потомства; морфометрія; лектинова гістохімія |
| Description: |
SUMMARY. By means of morphometric and lectin histochemistry methods the impact of maternal hyperthyroidism on the structural components of progeny testes on the successive stages of postnatal ontogeny was investigated. The aim of the study – to invesigate the impact of maternal hyperthyroidism on the micromorphology and glycan profile of progeny testes. Material and Methods. Hyperthyroidism was induced by feeding experimental group of animals with 100 mkg/kg of L-thyroxine for two weeks before pregnancy, throughout the gestational and lactation period. The lectin panel included GNA, PNA, SBA, WGA, SNA, and LABA. Results. On the 20th prenatal and 1st postnatal days within the progeny testes maternal hyperthyroidism induced significant decrease of interstitial connective tissue content, which was accompanied by the enhanced proliferative activity of Sertoli cells of seminiferous cords. On postnatal day 20th increased proliferative rate of the spermatogenic epithelium was combined with reduction of lectin receptors sites in spermatocytes located within seminiferous tubules adulmenal compartment. On postnatal day 40th experimental group animals demonstrated acceleration of acrosomal biogenesis, destructive changes in cellular components of seminiferous tubules with diminution of their diameter and compensatory interstitial space expansion. Differences in morphometric parameters and lectin labeling of testicular components of control and experimental group rats were maximally expressed on the prenatal day 20th with subsequent deminishing in sexually mature animals, indicating a transient impact of maternal hyperthyroidism on the histophysiology of progeny testes. A trend for reduction of lectin receptor sites in progeny testes under the influence of maternal hyperthyroidism has been noted, but no significant qualitative differences in their carbohydrate determinants were detected so far. In the present study it was documented intense labeling of fetal Leydig cells with GNA and LABA, of acrosomal granules and caps of ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
Ukrainian |
| Relation: |
https://ojs.tdmu.edu.ua/index.php/zdobutky-eks-med/article/view/10393/10099; https://repository.tdmu.edu.ua//handle/123456789/13980 |
| DOI: |
10.11603/1811-2471.2019.v.i3.10393 |
| Availability: |
https://repository.tdmu.edu.ua//handle/123456789/13980; https://ojs.tdmu.edu.ua/index.php/zdobutky-eks-med/article/view/10393; https://doi.org/10.11603/1811-2471.2019.v.i3.10393 |
| Accession Number: |
edsbas.9BCD7B87 |
| Database: |
BASE |