| Title: |
Laboratory evidence that dinotefuran, pyriproxyfen and permethrin combination abrogates Leishmania infantum transmissibility by sick dogs |
| Authors: |
Bongiorno G.; Bosco A.; Bianchi R.; Rinaldi L.; Foglia Manzillo V.; Gizzarelli M.; Maurelli M. P.; Giaquinto D.; El Houda Ben Fayala N.; Varloud M.; Crippa A.; Oliva G.; Gradoni L.; Cringoli G. |
| Contributors: |
Bongiorno, G.; Bosco, A.; Bianchi, R.; Rinaldi, L.; Foglia Manzillo, V.; Gizzarelli, M.; Maurelli, M. P.; Giaquinto, D.; El Houda Ben Fayala, N.; Varloud, M.; Crippa, A.; Oliva, G.; Gradoni, L.; Cringoli, G. |
| Publication Year: |
2022 |
| Collection: |
IRIS Università degli Studi di Napoli Federico II |
| Subject Terms: |
affected dog; Leishmania infantum; sand flie; transmissibility; xenodiagnosis |
| Description: |
Dogs are reservoir hosts of leishmaniasis caused by Leishmania infantum and transmitted by phlebotomine vectors. The effect of dinotefuran, pyriproxyfen and permethrin spot-on solution (Vectra®3D, Ceva Santé Animale, Libourne, France) on Leishmania transmissibility by naturally infected dogs via reared Phlebotomus perniciosus, was assessed. Dogs affected by leishmaniasis were submitted to xenodiagnosis and 6 infecting >10% of insects were treated topically on day 0. Antifeeding, insecticidal and anti-transmissibility effects were evaluated through xenodiagnoses performed on days 1, 7 and 28, using individual pre-treatment parameters as control. Feeding and mortality rates were assessed at 24 h, whereas promastigote infection, maturation and burden were assessed up to 96 h post blood meal (potentially infectious rate). On day 1, the anti-feeding efficacy was >95% in 4 dogs, insecticidal efficacy 100% in 4 dogs, and anti-transmissibility effect 100% in 6 dogs. Efficacy rates recorded on day 7 were very similar to day 1. On day 28, anti-feeding and insecticidal efficacy values were much broader, ranging 32.6–100% and 7.7–94.4%, respectively. Potentially infectious insects were recorded from two dogs, with sharp decrease in transmissibility rate as compared with pre-treatment condition. Altogether, Vectra®3D abrogated by >98% the potential Leishmania transmissibility by the examined pool of infected dogs over 1 month. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/WOS:000713240200001; journal:MEDICAL AND VETERINARY ENTOMOLOGY; https://hdl.handle.net/11588/868020 |
| DOI: |
10.1111/mve.12553 |
| Availability: |
https://hdl.handle.net/11588/868020; https://doi.org/10.1111/mve.12553 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Accesso privato/ristretto |
| Accession Number: |
edsbas.9C195330 |
| Database: |
BASE |