| Title: |
Comprehension of acoustically degraded speech in Alzheimer’s disease and primary progressive aphasia |
| Authors: |
Jiang, Jessica; Johnson, Jeremy C S; Requena-Komuro, Maï-Carmen; Benhamou, Elia; Sivasathiaseelan, Harri; Chokesuwattanaskul, Anthipa; Nelson, Annabel; Nortley, Ross; Weil, Rimona S; Volkmer, Anna; Marshall, Charles R; Bamiou, Doris-Eva; Warren, Jason D; Hardy, Chris J D |
| Contributors: |
The Dementia Research Centre; Alzheimer’s Research UK; Brain Research Trust; The Wolfson Foundation; Alzheimer’s Society; the Royal National Institute for Deaf People, Alzheimer’s Research UK; National Institute for Health Research University College London Hospitals Biomedical Research Centre; the Wellcome Trust; UK Research and Innovation; Creative Commons Attribution; Frontotemporal Dementia Research Studentship in Memory of David Blechner; The National Brain Appeal; Association of British Neurologists Clinical Research Training Fellowship; Wellcome Trust PhD studentship; Brain Research UK PhD Studentship; Clinical Research Fellowship; Leonard Wolfson Experimental Neurology Centre; NIHR Advanced Fellowship; Bart’s Charity and the National Institute for Health Research; Wellcome Clinical Research Career Development Fellowship; Royal National Institute for Deaf People; RNID-Dunhill Medical Trust Pauline Ashley Fellowship; Wellcome Institutional Strategic Support Fund Award; National Institute for Health Research; NIHR [Invention for Innovation; NIHR; Department of Health and Social Care |
| Source: |
Brain ; volume 146, issue 10, page 4065-4076 ; ISSN 0006-8950 1460-2156 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2023 |
| Description: |
Successful communication in daily life depends on accurate decoding of speech signals that are acoustically degraded by challenging listening conditions. This process presents the brain with a demanding computational task that is vulnerable to neurodegenerative pathologies. However, despite recent intense interest in the link between hearing impairment and dementia, comprehension of acoustically degraded speech in these diseases has been little studied. Here we addressed this issue in a cohort of 19 patients with typical Alzheimer’s disease and 30 patients representing the three canonical syndromes of primary progressive aphasia (non-fluent/agrammatic variant primary progressive aphasia; semantic variant primary progressive aphasia; logopenic variant primary progressive aphasia), compared to 25 healthy age-matched controls. As a paradigm for the acoustically degraded speech signals of daily life, we used noise-vocoding: synthetic division of the speech signal into frequency channels constituted from amplitude-modulated white noise, such that fewer channels convey less spectrotemporal detail thereby reducing intelligibility. We investigated the impact of noise-vocoding on recognition of spoken three-digit numbers and used psychometric modelling to ascertain the threshold number of noise-vocoding channels required for 50% intelligibility by each participant. Associations of noise-vocoded speech intelligibility threshold with general demographic, clinical and neuropsychological characteristics and regional grey matter volume (defined by voxel-based morphometry of patients’ brain images) were also assessed. Mean noise-vocoded speech intelligibility threshold was significantly higher in all patient groups than healthy controls, and significantly higher in Alzheimer’s disease and logopenic variant primary progressive aphasia than semantic variant primary progressive aphasia (all P < 0.05). In a receiver operating characteristic analysis, vocoded intelligibility threshold discriminated Alzheimer’s ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/brain/awad163 |
| DOI: |
10.1093/brain/awad163/50713413/awad163.pdf |
| Availability: |
https://doi.org/10.1093/brain/awad163; https://academic.oup.com/brain/advance-article-pdf/doi/10.1093/brain/awad163/50713413/awad163.pdf; https://academic.oup.com/brain/article-pdf/146/10/4065/51824224/awad163.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.9C2D34FF |
| Database: |
BASE |