| Title: |
Association of proteinuria and hypertensionwith incident atrial fibrillation in an elderly population: nationwide data from a community-based elderly cohort |
| Authors: |
Park, YJ; Yang, PS; Yu, HT; Kim, TH; Jang, E; Uhm, JS; Pak, HN; Lee, MH; Lip, GYH; Joung, B |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2022 |
| Collection: |
The University of Liverpool Repository |
| Description: |
Objective: The excess risk of atrial fibrillation in relation to the presence of proteinuria associated with hypertension has not been well elucidated. We aimed to determine the effect of hypertension and/or proteinuria on the incidence of atrial fibrillation. Second, we evaluated whether the associations with temporal changes in proteinuria status on the incidence of atrial fibrillation. Methods and results: A total of 85 434 participants with hypertension and 125 912 participants without hypertension with age at least 60 years from the Korea National Health Insurance Service-Senior cohort were included. Amongst controls (participants without proteinuria and hypertension), hypertension only, proteinuria only, and hypertension with proteinuria groups, the adjusted incidences of atrial fibrillation were 0.51, 0.69. 0.78 and 0.99 per 100 person-years, respectively after inverse probability of treatment weighting. Compared with controls, the weighted risks of atrial fibrillation in the hypertension only, proteinuria only and hypertension with proteinuria groups were increased by 37% (hazard ratio 1.37, 95% confidence interval, CI 1.30-1.44, P 0.001), 55% (hazard ratio 1.55, 95% CI 1.28-1.88, P |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
0263-6352 |
| Relation: |
https://livrepository.liverpool.ac.uk/3172141/1/Association%20of%20proteinuria%20and%20hypertension%20with%20incident%20atrial%20fibrillation%20in%20an%20elderly%20population%20nationwide%20data%20from%20.pdf; Park, YJ, Yang, PS, Yu, HT, Kim, TH, Jang, E, Uhm, JS, Pak, HN, Lee, MH, Lip, GYH orcid:0000-0002-7566-1626 and Joung, B (2022) Association of proteinuria and hypertensionwith incident atrial fibrillation in an elderly population: nationwide data from a community-based elderly cohort Journal of Hypertension, 40 (1). pp. 128-135. ISSN 0263-6352, 1473-5598 |
| DOI: |
10.1097/hjh.0000000000002987 |
| Availability: |
https://livrepository.liverpool.ac.uk/3172141/; https://doi.org/10.1097/hjh.0000000000002987; https://livrepository.liverpool.ac.uk/3172141/1/Association%20of%20proteinuria%20and%20hypertension%20with%20incident%20atrial%20fibrillation%20in%20an%20elderly%20population%20nationwide%20data%20from%20.pdf |
| Accession Number: |
edsbas.9C64E8E0 |
| Database: |
BASE |