| Title: |
Vitamin K Supplementation for Prevention of Vascular Calcification in Chronic Kidney Disease Patients: Are We There Yet? |
| Authors: |
Stefanos Roumeliotis; Anila Duni; Vasilios Vaios; Athanasios Kitsos; Vassilios Liakopoulos; Evangelia Dounousi |
| Source: |
Nutrients, Vol 14, Iss 5, p 925 (2022) |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2022 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
cardiovascular disease; chronic kidney disease; end-stage kidney disease; hemodialysis; Matrix Gla Protein; menaquinone-7; Nutrition. Foods and food supply; TX341-641 |
| Description: |
Chronic Kidney Disease (CKD) patients are at high risk of presenting with arterial calcification or stiffness, which confers increased cardiovascular mortality and morbidity. In recent years, it has become evident that VC is an active process regulated by various molecules that may act as inhibitors of vessel mineralization. Matrix Gla Protein (MGP), one the most powerful naturally occurring inhibitors of arterial calcification, requires vitamin K as a co-factor in order to undergo post-translational γ-carboxylation and phosphrorylation and become biologically active. The inactive form of MGP (dephosphorylated, uncarboxylated dp-ucMGP) reflects vitamin K deficiency and has been repeatedly associated with surrogate markers of VC, stiffness, and cardiovascular outcomes in CKD populations. As CKD is a state of progressive vitamin K depletion and VC, research has focused on clinical trials aiming to investigate the possible beneficial effects of vitamin K in CKD and dialysis patients. In this study, we aim to review the current evidence regarding vitamin K supplementation in uremic patients. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.mdpi.com/2072-6643/14/5/925; https://doaj.org/toc/2072-6643; https://doaj.org/article/ad14c668abc24dc5afd468723c8ec078 |
| DOI: |
10.3390/nu14050925 |
| Availability: |
https://doi.org/10.3390/nu14050925; https://doaj.org/article/ad14c668abc24dc5afd468723c8ec078 |
| Accession Number: |
edsbas.9C8A8AF7 |
| Database: |
BASE |