| Title: |
Hbcab positivity is a risk factor for an increased detectability of hiv rna after switching to a two-drug regimen lamivudine-based (2dr-3tc-based) treatment: Analysis of a multicenter italian cohort |
| Authors: |
Malagnino V.; Teti E.; Compagno M.; Coppola L.; Salpini R.; Svicher V.; Basso M.; Battagin G.; Panese S.; Rossi M. C.; Scaggiante R.; Zago D.; Iannetta M.; Parisi S. G.; Andreoni M.; Sarmati L. |
| Contributors: |
Malagnino, V.; Teti, E.; Compagno, M.; Coppola, L.; Salpini, R.; Svicher, V.; Basso, M.; Battagin, G.; Panese, S.; Rossi, M. C.; Scaggiante, R.; Zago, D.; Iannetta, M.; Parisi, S. G.; Andreoni, M.; Sarmati, L. |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2021 |
| Collection: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Subject Terms: |
2DR; 3TC/DTG; Anti-HBc; Dual therapy; HIV/HBV coinfection |
| Description: |
The aim of this study was to evaluate whether the presence of anti-hepatitis B (HBV) c antibodies (HBcAb positivity) could influence the control of Human Immunodeficiency Virus (HIV) viremia in patients living with HIV (PLWH) who switch a to two-drug antiretroviral therapy (2DR) containing lamivudine (3TC) (2DR-3TC). A retrospective observational multicenter study was conducted on 166 PLWH switching to the 2DR-3TC-based regimen: 58 HBcAb-positive and 108 HBcAb-negative patients. The HBcAb-positive PLWH group demonstrated a significantly higher percentage of subjects with very low-level viremia at all time points after switching (6th month: < 31% vs 17.6%, p = 0.047; 12th month 34% vs 27.5%, p = 0.001; 24th month 37% vs 34.2, p = 0.003 of the HBcAb-positive and HBcAb-negative groups, respectively) and a higher percentage of subjects with detectable HIV RNA greater than 20 copies/mL 12 and 24 months after switching (12 months 32% vs 11%, p = 0.001; 24 months 37% vs 13.9%, p = 0.003 of the HBcAb-positive and HBcAb-negative groups, respectively). Logistic regression analysis showed that an increase in age of ten years (OR 2.48 (95% CI 1.58–3.89), p < 0.0001) and the presence of HBcAb positivity (OR 2.7 (5% CI 1.05–6.9), p = 0.038) increased the risk of detectability of HIV RNA by nearly three-fold after switching to 2DR-3TC. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/33671934; info:eu-repo/semantics/altIdentifier/wos/WOS:000622807500001; volume:9; issue:2; firstpage:1; lastpage:13; numberofpages:13; journal:MICROORGANISMS; https://hdl.handle.net/11577/3420409 |
| DOI: |
10.3390/microorganisms9020396 |
| Availability: |
https://hdl.handle.net/11577/3420409; https://doi.org/10.3390/microorganisms9020396 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.9C97B8B1 |
| Database: |
BASE |