| Title: |
A Simple Endoscopic Score for Crohn's Disease (SES-CD) ≥ 7 Predicts Disease Progression |
| Authors: |
Peraza, Jellyana; Kaper, Marco Emilio; Bargas, Andre; Kim, Iris; Agrawal, Manasi; Larsen, Lone; Jacobsen, Henrik Albaek; Jess, Tine; Colombel, Jean-Frederic; Torres, Joana; Ungaro, Ryan C.; Ananthakrishnan, Ashwin N. |
| Source: |
Peraza, J, Kaper, M E, Bargas, A, Kim, I, Agrawal, M, Larsen, L, Jacobsen, H A, Jess, T, Colombel, J-F, Torres, J, Ungaro, R C & Ananthakrishnan, A N 2025, 'A Simple Endoscopic Score for Crohn's Disease (SES-CD) ≥ 7 Predicts Disease Progression', Alimentary Pharmacology & Therapeutics, vol. 61, no. 6, pp. 1011-1018. https://doi.org/10.1111/apt.18492 |
| Publication Year: |
2025 |
| Collection: |
Aalborg University (AAU): Publications / Aalborg Universitet: Publikationer |
| Subject Terms: |
Crohn's disease; SES-CD; endoscopic severity; inflammatory bowel disease |
| Description: |
BACKGROUND: Up to 30% of patients with Crohn's disease (CD) will experience a mild disease course. However, there is no consensus definition for mild CD. AIM: To examine the Simple Endoscopic Score for Crohn's disease (SES-CD) thresholds best associated with low likelihood of long-term disease progression. METHODS: We conducted a multicentre retrospective cohort study at three tertiary care centres in United States and Europe. We analysed data from 177 surgery-naïve patients with CD who had endoscopic assessment while not on immunosuppressive therapy. The primary outcome was disease progression (systemic steroids, biologic or immunomodulator therapy initiation; new stricturing or penetrating complications; or CD-related hospitalisation or surgery). Univariable and multivariable Cox proportional hazards modelling identified predictors of the primary outcome at 2 and 5 years following endoscopy. RESULTS: Disease progression occurred in 23% and 35% of patients at years two and five, respectively. Endoscopic severity at enrolment independently predicted disease progression. Compared to those with an SES-CD of 0, an SES-CD ≥ 7 had a greater risk of progression at 2 years (HR 2.50, 95% CI 1.09-5.72) and 5 years (HR 2.89, 95% CI 1.41-5.91). SES-CD > 7 remained independently predictive of disease progression among the 129 immunosuppression-naïve patients (HR 5.65, 95% CI 1.49-21.52) and after excluding patients with prior penetrating disease (HR 2.32, 95% CI 1.00-5.45). CONCLUSIONS: SES-CD ≥ 7 predicts disease progression in mild CD. A score ≤ 6 may help identify patients less likely to progress and be part of the definition of mild CD. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0269-2813; 0953-0673 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39757503; info:eu-repo/semantics/altIdentifier/pissn/0269-2813; info:eu-repo/semantics/altIdentifier/eissn/0953-0673 |
| DOI: |
10.1111/apt.18492 |
| Availability: |
https://vbn.aau.dk/da/publications/76952b3b-b20e-448a-a9e4-1e8fb42052cf; https://doi.org/10.1111/apt.18492; https://www.scopus.com/pages/publications/85214410536 |
| Rights: |
info:eu-repo/semantics/closedAccess |
| Accession Number: |
edsbas.9CBE9E20 |
| Database: |
BASE |