| Title: |
Increased production of b-cell activating cytokines and altered peripheral b-cell subset distribution during hiv-related classical hodgkin lymphoma |
| Authors: |
Lievin, Raphael; Hendel-Chavez, Houria; Baldé, Aliou; Lancar, Rémi; Algarte-Génin, Michèle; Krzysiek, Roman; Costagliola, Dominique; Assoumou, Lambert K.; Taoufik, Yassine; Besson, Caroline M. |
| Contributors: |
Centre Hospitalier de Versailles André Mignot (CHV); Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Immunologie intégrative des tumeurs et immunothérapie des cancers (INTIM (U1186)); Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse; AP-HP. Université Paris Saclay-AP-HP. Université Paris Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; UFR Sciences de la santé Simone Veil (UVSQ Santé); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay; Agence Nationale de Recherches sur le Sida et les Hépatites Virales, ANRS: Lymphovir-CO16; Funding: This research was funded by ANRS, grant number: Lymphovir-CO16. |
| Source: |
ISSN: 2072-6694. |
| Publisher Information: |
CCSD; MDPI |
| Publication Year: |
2022 |
| Collection: |
Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| Subject Terms: |
Immunology; Hodgkin lymphoma; HIV; Cytokines; [SDV.CAN]Life Sciences [q-bio]/Cancer; [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology; [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases |
| Description: |
International audience ; Classical Hodgkin Lymphoma incidence increases in HIV-1-infected patients (HIV-cHL). HIV infection is associated with higher B-cell activation. Here, in 38 HIV-cHL patients from the French cohort ANRS-CO16 Lymphovir, we examined longitudinally over 24 months the serum levels of the B-cell activating cytokines IL10, IL6, and BAFF, and blood distribution of B-cell subsets. Fourteen HIV-cHL patients were also compared to matched HIV-infected controls without cHL. IL10, IL6, and BAFF levels were higher in HIV-cHL patients than in controls (p < 0.0001, p = 0.002, and p < 0.0001, respectively). Cytokine levels increased in patients with advanced-stage lymphoma compared to those with limited-stage (p = 0.002, p = 0.03, and p = 0.01, respectively). Cytokine levels significantly decreased following HIV-cHL diagnosis and treatment. Blood counts of whole B-cells were similar in HIV-cHL patients and controls, but the distribution of B-cell subsets was different with higher ratios of naive B-cells over memory B-cells in HIV-cHL patients. Blood accumulation of naive B-cells was more marked in patients with advanced cHL stages (p = 0.06). During the follow-up, total B-cell counts increased (p < 0.0001), and the proportion of naive B-cells increased further (p = 0.04). Together the results suggest that in HIV-infected patients, cHL is associated with a particular B-cell-related environment that includes increased production of B-cell-activating cytokines and altered peripheral distribution of B-cell subsets. This B-cell-related environment may fuel the process of tumorigenesis. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35008292; PUBMED: 35008292; PUBMEDCENTRAL: PMC8750095 |
| DOI: |
10.3390/cancers14010128 |
| Availability: |
https://hal.science/hal-03524494; https://hal.science/hal-03524494v1/document; https://hal.science/hal-03524494v1/file/cancers-14-00128.pdf; https://doi.org/10.3390/cancers14010128 |
| Rights: |
http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.9CD611AC |
| Database: |
BASE |