| Title: |
Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index |
| Authors: |
Hoggart, CJ; Venturini, G; Ascari, G; Lamparter, D; Macé, A; Rüeger, S; Bergmann, S; Rivolta, C; Kutalik, Z; Mangino, M; Spector, TD; Yuan, W; Bell, JT; Gomez, F; Borecki, IB; Zhao, JH; Luan, J; Scott, RA; Wareham, NJ; Loos, RJF; Teumer, A; Homuth, G; Winkler, TW; Heid, IM; Tšernikova, N; Mihailov, E; Metspalu, A; Ehret, GB; Arking, DE; Chakravarti, A; Zhang, W; Chambers, JC; Beckmann, JS; Esko, T; Lopez, MF; Vendantam, S; Berndt, SI; Gustafsson, S; Mägi, R; Ganna, A; Wheeler, E; Feitosa, MF; Justice, AE; Monda, KL; Croteau-Chonka, DC; Day, FR; Fall, T; Ferreira, T; Gentilini, D; Jackson, AU; Randall, JC; Vedantam, S; Willer, CJ; Wood, AR; Workalemahu, T; Hu, Y-J; Lee, SH; Liang, L; Lin, D-Y; Min, JL; Neale, BM; Thorleifsson, G; Yang, J; Albrecht, E; Amin, N; Bragg-Gresham, JL; Cadby, G; den Heijer, M; Eklund, N; Fischer, K; Goel, A; Hottenga, J-J; Huffman, JE; Jarick, I; Johansson, A; Johnson, T; Kanoni, S; Kleber, ME; König, IR; Kristiansson, K; Lamina, C; Lecoeur, C; Li, G; McArdle, WL; Medina-Gomez, C; Müller-Nurasyid, M; Ngwa, JS; Nolte, IM; Paternoster, L; Pechlivanis, S; Perola, M; Peters, MJ; Preuss, M; Rose, LM; Shi, J; Shungin, D; Smith, AV; Strawbridge, RJ; Surakka, I; Trip, MD; Tyrer, J; Van Vliet-Ostaptchouk, JV; Vandenput, L; Waite, LL; Absher, D; Asselbergs, FW; Atalay, M; Attwood, AP; Balmforth, AJ; Basart, H; Beilby, J; Bonnycastle, LL; Brambilla, P; Bruinenberg, M; Campbell, H; Chasman, DI; Chines, PS; Collins, FS; Connell, JM; Cookson, W; de Faire, U; de Vegt, F; Dei, M; Dimitriou, M; Edkins, S; Estrada, K; Evans, DM; Farrall, M; Ferrario, MM; Ferrières, J; Franke, L; Frau, F; Gejman, PV; Grallert, H; Grönberg, H; Gudnason, V; Hall, AS; Hall, P; Hartikainen, A-L; Hayward, C; Heard-Costa, NL; Heath, AC; Hebebrand, J; Hu, FB; Hunt, SE; Hyppönen, E; Iribarren, C; Jacobs, KB; Jansson, J-O; Jula, A; Kähönen, M; Kathiresan, S; Kee, F; Khaw, K-T; Kivimaki, M; Koenig, W; Kraja, AT; Kumari, M; Kuulasmaa, K; Kuusisto, J; Laitinen, JH; Lakka, TA; Langenberg, C; Launer, LJ; Lind, L; Lindström, J; Liu, J; Liuzzi, A; Lokki, M-L; Lorentzon, M; Madden, PA; Magnusson, PK; Manunta, P; Marek, D; März, W; Leach, IM; McKnight, B; Medland, SE; Milani, L; Montgomery, GW; Mooser, V; Mühleisen, TW; Munroe, PB; Musk, AW; Narisu, N; Navis, G; Nicholson, G; Nohr, EA; Ong, KK; Oostra, BA; Palmer, CNA; Palotie, A; Peden, JF; Pedersen, N; Peters, A; Polasek, O; Pouta, A; Pramstaller, PP; Prokopenko, I; Pütter, C; Radhakrishnan, A; Raitakari, O; Rendon, A; Rivadeneira, F; Rudan, I; Saaristo, TE; Sambrook, JG; Sanders, AR; Sanna, S; Saramies, J; Schipf, S; Schreiber, S; Schunkert, H; Shin, S-Y; Signorini, S; Sinisalo, J; Skrobek, B; Soranzo, N; Stancakova, A; Stark, K; Stephens, JC; Stirrups, K; Stolk, RP; Stumvoll, M; Swift, AJ; Theodoraki, EV; Thorand, B; Tregouet, D-A; Tremoli, E; Van der Klauw, MM; van Meurs, JBJ; Vermeulen, SH; Viikari, J; Virtamo, J; Vitart, V; Waeber, G; Wang, Z; Widen, E; Wild, SH; Willemsen, G; Winkelmann, BR; Witteman, JCM; Wolffenbuttel, BHR; Wong, A; Wright, AF; Zillikens, MC; Amouyel, P; Boehm, BO; Boerwinkle, E; Boomsma, DI; Caulfield, MJ; Chanock, SJ; Cupples, LA; Cusi, D; Dedoussis, GV; Erdmann, J; Eriksson, JG; Franks, PW; Froguel, P; Gieger, C; Gyllensten, U; Hamsten, A; Harris, TB; Hengstenberg, C; Hicks, AA; Hingorani, A; Hinney, A; Hofman, A; Hovingh, KG; Hveem, K; Illig, T; Jarvelin, M-R; Jöckel, K-H; Keinanen-Kiukaanniemi, SM; Kiemeney, LA; Kuh, D; Laakso, M; Lehtimäki, T; Levinson, DF; Martin, NG; Morris, AD; Nieminen, MS; Njølstad, I; Ohlsson, C; Oldehinkel, AJ; Ouwehand, WH; Palmer, LJ; Penninx, B; Power, C; Province, MA; Psaty, BM; Qi, L; Rauramaa, R; Ridker, PM; Ripatti, S; Salomaa, V; Samani, NJ; Snieder, H; Sørensen, TIA; Stefansson, K; Tönjes, A; Tuomilehto, J; Uitterlinden, AG; Uusitupa, M; van der Harst, P; Vollenweider, P; Wallaschofski, H; Watkins, H; Wichmann, H-E; Wilson, JF; Abecasis, GR; Assimes, TL; Barroso, I; Boehnke, M; Deloukas, P; Fox, CS; Frayling, T; Groop, LC; Haritunian, T; Hunter, D; Kaplan, RC; Karpe, F; Moffatt, M; Mohlke, KL; O'Connell, JR; Pawitan, Y; Schadt, EE; Schlessinger, D; Steinthorsdottir, V; Strachan, DP; Thorsteinsdottir, U; van Duijn, CM; Visscher, PM; Di Blasio, AM; Hirschhorn, JN; Lindgren, CM; Morris, AP; Meyre, D; Scherag, A; McCarthy, MI; Speliotes, EK; North, KE; Ingelsson, E; Bochud, P-Y; Barcella, M; Salvi, E; Dauvilliers, Y; Benyamin, B; Whitfield, JB; Kemp, JP; Da Smith, G; Berg, J; Blackwood, D; Cavanagh, J; Connell, J; Connor, M; Cunningham-Burley, S; Deary, I; Dominiczak, A; Ellis, P; FitzPatrick, B; Ford, I; Gertz, R; Grau, A; Haddow, G; Jackson, C; Kerr, S; Lindsay, R; McGilchrist, M; McIntyre, D; Morris, A; Morton, R; Muir, W; Murray, G; Palmer, C; Pell, J; Philp, A; Porteous, D; Porteous, M; Procter, R; Ralston, S; Reid, D; Sinnott, R; Smith, B; St Clair, D; Sullivan, F; Sweetland, M; Ure, J; Watt, G; Wolf, R; Wright, A; Hastie, ND; de Bakker, P; Bültmann, U; Geleijnse, M; Harst, PVD; Koppelman, G; Rosmalen, JGM; van Rossum, L; Smidt, H; Swertz, MA; Alizadeh, B; de Boer, R; Boezen, HM; Hillege, H; van der Klauw, M; Ormel, J; Postma, D; Rosmalen, J; Slaets, J; Stolk, R; Wolffenbuttel, B; Wijmenga, C; Russo, A; Fiorito, G; Matullo, G; Guarrera, S; Moradpour, D; Iranzo, A; Santamaria, J; Lammers, GJ; Aubert, V; Heim, MH; Peraita-Adrados, R; Negro, F; Schmidt, CO; Völzke, H; Strauch, K; Kooner, JS; Paccaud, F; Bochud, M; Rousson, V; Tafti, M; Frayling, TM |
| Source: |
PLoS Genetics , 10 (7) , Article e1004508. (2014) |
| Publication Year: |
2014 |
| Collection: |
University College London: UCL Discovery |
| Description: |
The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their parental origin. We present a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. The method exploits increased phenotypic variance in the heterozygous genotype group relative to the homozygous groups. We applied the method to >56,000 unrelated individuals to search for POEs influencing body mass index (BMI). Six lead SNPs were carried forward for replication in five family-based studies (of ~4,000 trios). Two SNPs replicated: the paternal rs2471083-C allele (located near the imprinted KCNK9 gene) and the paternal rs3091869-T allele (located near the SLC2A10 gene) increased BMI equally (beta = 0.11 (SD), P |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/1447540/1/journal.pgen.1004508.pdf; https://discovery.ucl.ac.uk/id/eprint/1447540/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/1447540/1/journal.pgen.1004508.pdf; https://discovery.ucl.ac.uk/id/eprint/1447540/ |
| Rights: |
open |
| Accession Number: |
edsbas.9D450EEE |
| Database: |
BASE |