Risk Factors for Persisting SARS-CoV-2 Infection in Patients with B-Cell Malignancies in the Omicron Era: A Multicenter Cohort Study
| Title: | Risk Factors for Persisting SARS-CoV-2 Infection in Patients with B-Cell Malignancies in the Omicron Era: A Multicenter Cohort Study |
|---|---|
| Authors: | Pasquini, Zeno; Toschi, Alice; Gibertoni, Dino; Amicucci, Armando; Casadei, Beatrice; Pellegrini, Cinzia; D'Abramo, Alessandra; De Marco, Patrizia; Bussini, Linda; Ciccone, Maria; Visentin, Alessandro; Olivares-Navarro, Paula; Bartoletti, Michele; Nicastri, Emanuele; Krampera, Mauro; Zinzani, Pier Luigi; Bonifazi, Francesca; Viale, Pierluigi; Palacios-Baena, Zaira R; Tacconelli, Evelina; Giannella, Maddalena; ORCHESTRA study group; Lorenzo Maria Canziani; Anna Maria Azzini; Gaia Maccarrone; Lorenza Lambertenghi; Natascia Caroccia; Michela Di Chiara; Francesca Simone; Alessandro Cilli; Federica Malerba; Martina Casarini; Alberto Pecorelli; Domenico Marzolla; Andrea Volpe; Filippo Miselli; Jesus Rodriguez-Baño; Maria Giulia Caponcello; Alicia Rodriguez-Fernandez; Julia Montero Benitez; Aurora Aleman Rodriguez; Lola Cubero Aranda |
| Contributors: | Pasquini, Zeno; Toschi, Alice; Gibertoni, Dino; Amicucci, Armando; Casadei, Beatrice; Pellegrini, Cinzia; D'Abramo, Alessandra; De Marco, Patrizia; Bussini, Linda; Ciccone, Maria; Visentin, Alessandro; Olivares-Navarro, Paula; Bartoletti, Michele; Nicastri, Emanuele; Krampera, Mauro; Zinzani, Pier Luigi; Bonifazi, Francesca; Viale, Pierluigi; Palacios-Baena, Zaira R; Tacconelli, Evelina; Giannella, Maddalena; Orchestra Study Group; Canziani, Lorenzo Maria; Azzini, Anna Maria; Maccarrone, Gaia; Lambertenghi, Lorenza; Caroccia, Natascia; Michela Di Chiara; Simone, Francesca; Cilli, Alessandro; Malerba, Federica; Casarini, Martina; Pecorelli, Alberto; Marzolla, Domenico; Volpe, Andrea; Miselli, Filippo; Rodriguez-Baño, Jesu; Maria Giulia Caponcello; Rodriguez-Fernandez, Alicia; Julia Montero Benitez; Aurora Aleman Rodriguez; Lola Cubero Aranda |
| Publication Year: | 2025 |
| Collection: | Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| Subject Terms: | B-cell malignancie; COVID-19 in hematologic patient; Persisting SARS-CoV-2 infection; anti-CD20 monoclonal antibody therapy; early antiviral treatment for SARS-CoV-2 |
| Description: | Background: Patients with B-cell malignancies are at high risk of persisting SARS-CoV-2 infection, which may delay oncologic treatments and increase morbidity. We aimed to assess risk factors for persisting infection in this population. Methods: We conducted a multicenter retrospective study across five tertiary hospitals between January 1, 2022, and January 1, 2023. Adult patients with B-cell malignancies and SARS-CoV-2 infection were included. Persisting infection was defined as viral shedding ≥21 days with clinical and/or radiological signs. Risk factors were evaluated through multivariable logistic regression. Results: Among 307 patients, 26.1% developed persisting infection. The cohort included non-Hodgkin lymphoma (67.4%), chronic lymphocytic leukemia (19.2%), and Hodgkin lymphoma (9.1%). Independent risk factors included anti-CD20 therapy (OR 3.22; 95% CI 2.37-4.39; p |
| Document Type: | article in journal/newspaper |
| File Description: | ELETTRONICO |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/40930215; info:eu-repo/semantics/altIdentifier/wos/WOS:001587797900002; volume:160; firstpage:1; lastpage:7; numberofpages:7; journal:INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES; https://hdl.handle.net/11562/1170190 |
| DOI: | 10.1016/j.ijid.2025.108053 |
| Availability: | https://hdl.handle.net/11562/1170190; https://doi.org/10.1016/j.ijid.2025.108053 |
| Accession Number: | edsbas.9D4B8C4B |
| Database: | BASE |