| Title: |
Higher schizotypy predicts better metabolic profile in unaffected siblings of patients with schizophrenia |
| Authors: |
Atbasoglu,E. Cem; Gumus-Akay,Guvem; Guloksuz,Sinan; Saka,Meram Can; Ucok,Alp; Alptekin,Koksal; Gullu,Sevim; van Os, Jim; Hersenen-Medisch 1; Brain |
| Publication Year: |
2018 |
| Subject Terms: |
Dopamine; Genetics; Insulin resistance; Schizophrenia; Schizotypy; Type 2 diabetes mellitus; Taverne; Pharmacology |
| Description: |
Rationale: Type 2 diabetes (T2D) is more frequent in schizophrenia (Sz) than in the general population. This association is partly accounted for by shared susceptibility genetic variants. Objective: We tested the hypotheses that a genetic predisposition to Sz would be associated with higher likelihood of insulin resistance (IR), and that IR would be predicted by subthreshold psychosis phenotypes. Methods: Unaffected siblings of Sz patients (n = 101) were compared with a nonclinical sample (n = 305) in terms of IR, schizotypy (SzTy), and a behavioural experiment of “jumping to conclusions”. The measures, respectively, were the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), Structured Interview for Schizotypy-Revised (SIS-R), and the Beads Task (BT). The likelihood of IR was examined in multiple regression models that included sociodemographic, metabolic, and cognitive parameters alongside group status, SIS-R scores, and BT performance. Results: Insulin resistance was less frequent in siblings (31.7%) compared to controls (43.3%) (p < 0.05), and negatively associated with SzTy, as compared among the tertile groups for the latter (p < 0.001). The regression model that examined all relevant parameters included the tSzTy tertiles, TG and HDL-C levels, and BMI, as significant predictors of IR. Lack of IR was predicted by the highest as compared to the lowest SzTy tertile [OR (95%CI): 0.43 (0.21–0.85), p = 0.015]. Conclusion: Higher dopaminergic activity may contribute to both schizotypal features and a favourable metabolic profile in the same individual. This is compatible with dopamine’s regulatory role in glucose metabolism via indirect central actions and a direct action on pancreatic insulin secretion. The relationship between dopaminergic activity and metabolic profile in Sz must be examined in longitudinal studies with younger unaffected siblings. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
0033-3158 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/372476 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/372476 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.9D4ED36F |
| Database: |
BASE |