| Title: |
Systemic and Tumor-directed Therapy for Oligorecurrent Metastatic Prostate Cancer (SATURN): Primary Endpoint Results from a Phase 2 Clinical Trial. |
| Authors: |
Nikitas, John; Rettig, Matthew; Shen, John; Reiter, Robert; Lee, Alan; Steinberg, Michael; Valle, Luca; Sachdeva, Ankush; Romero, Tahmineh; Calais, Jeremie; Czernin, Johannes; Nickols, Nicholas; Kishan, Amar |
| Source: |
European Urology, vol 85, iss 6 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2024 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
Abiraterone acetate; Androgen annihilation therapy; Apalutamide; Leuprolide; Metastasis-directed therapy; Oligorecurrence; Prostate cancer; Stereotactic body radiotherapy; Humans; Male; Prostatic Neoplasms; Aged; Radiosurgery; Neoplasm Recurrence; Local; Middle Aged; Thiohydantoins; Prednisone; Prostate-Specific Antigen; Neoplasm Metastasis; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Androgen Antagonists; Treatment Outcome; Antineoplastic Agents; Hormonal |
| Description: |
Nearly all men with metastatic hormone-sensitive prostate cancer treated with intermittent androgen deprivation therapy (ADT) experience recurrence within 6mo of testosterone recovery. We conducted a single-arm phase 2 trial to evaluate whether addition of dual androgen receptor pathway inhibitors (ARPIs) and metastasis-directed stereotactic body radiotherapy (SBRT) to intermittent ADT improves recurrence rates for men with between one and five nonvisceral, extrapelvic metastases on prostate-specific membrane antigen positron emission tomography/computed tomography after prior radical prostatectomy. Patients received 6mo of androgen annihilation therapy (AAT; leuprolide, abiraterone acetate plus prednisone, and apalutamide) and metastasis-directed SBRT. The primary endpoint was the percentage of patients with prostate-specific antigen (PSA) |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt3k18x9ps; https://escholarship.org/uc/item/3k18x9ps; https://escholarship.org/content/qt3k18x9ps/qt3k18x9ps.pdf |
| DOI: |
10.1016/j.eururo.2024.01.021 |
| Availability: |
https://escholarship.org/uc/item/3k18x9ps; https://escholarship.org/content/qt3k18x9ps/qt3k18x9ps.pdf; https://doi.org/10.1016/j.eururo.2024.01.021 |
| Rights: |
public |
| Accession Number: |
edsbas.9D700231 |
| Database: |
BASE |