| Title: |
Steroid‐responsive neutropenia in a cat with progressive feline leukemia virus infection |
| Authors: |
Stavroulaki, Evangelia M.; Mylonakis, Mathios E.; Papanikolaou, Eleni; Hatzis, Aristodimos; Xenoulis, Panagiotis G. |
| Source: |
Veterinary Clinical Pathology ; volume 49, issue 3, page 389-393 ; ISSN 0275-6382 1939-165X |
| Publisher Information: |
Wiley |
| Publication Year: |
2020 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
An 8‐month‐old female domestic shorthair cat was presented to the Animal Medical Center with anorexia, lethargy, and mild gastrointestinal signs. A CBC revealed a profound neutropenia, and serologic testing with an in‐house test kit (SNAP FIV/FeLV Combo, IDEXX) was positive for feline leukemia virus (FeLV) antigen. Serial hematologic examinations during hospitalization showed a persistent neutropenia with occasionally severe anemia and thrombocytopenia. Prednisolone administration afforded complete hematologic remission within 3 days. Four weeks after the premature discontinuation of prednisolone, the patient relapsed; however, complete and prolonged hematologic remission was achieved after prednisolone was re‐induced. Bone marrow aspiration cytology was consistent with immune‐mediated destruction of the mature myeloid cells. steroid‐responsive (likely immune‐mediated) cytopenias rarely occur in cats with progressive FeLV infection. Although only a few cases of FeLV‐positive, severely neutropenic cats that responded to immunosuppressive therapy have been reported, this case highlights that a grave prognosis should not always be given to these FeLV‐positive cats. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/vcp.12896 |
| Availability: |
https://doi.org/10.1111/vcp.12896; https://onlinelibrary.wiley.com/doi/pdf/10.1111/vcp.12896; https://onlinelibrary.wiley.com/doi/full-xml/10.1111/vcp.12896 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.9DA0FA13 |
| Database: |
BASE |