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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Title:	Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Authors:	Surendran P; Feofanova EV; Lahrouchi N; Ntalla I; Karthikeyan S; Cook J; Chen LY; Mifsud B; Yao C; Kraja AT; Cartwright JH; Hellwege JN; Giri A; Tragante V; Thorleifsson G; Liu DJJ; Prins BP; Stewart ID; Cabrera CP; Eales JM; Akbarov A; Auer PL; Bielak LF; Bis JC; Braithwaite VS; Brody JA; Daw EW; Warren HR; Drenos F; Nielsen SF; Faul JD; Fauman EB; Fava C; Ferreira T; Foley CN; Franceschini N; Gao H; Giannakopoulou O; Giulianini F; Gudbjartsson DF; Guo XQ; Harris SE; Havulinna AS; Helgadottir A; Huffman JE; Hwang SJ; Kanoni S; Kontto J; Larson MG; Li-Gao R; Lindstrom J; Lotta LA; Lu YC; Luan JA; Mahajan A; Malerba G; Masca NGD; Mei H; Menni C; Mook-Kanamori DO; Mosen-Ansorena D; Muller-Nurasyid M; Pare G; Paul DS; Perola M; Poveda A; Rauramaa R; Richard M; Richardson TG; Sepulveda N; Sim XL; Smith AV; Smith JA; Staley JR; Stanakova A; Sulem P; Theriault S; Thorsteinsdottir U; Trompet S; Varga TV; Edwards DRV; Veronesi G; Weiss S; Willems SM; Yao J; Young RB; Yu B; Zhang WH; Zhao JH; Zhao W; Evangelou E; Aeschbacher S; Asllanaj E; Blankenberg S; Bonnycastle LL; Bork-Jensen J; Brandslund I; Braund PS; Burgess S; Cho K; Christensen C; Connell J; de Mutsert R; Dominiczak AF; Dorr M; Eiriksdottir G; Farmaki AE; Gaziano JM; Grarup N; Grove ML; Hallmans G; Hansen T; Have CT; Heiss G; Jorgensen ME; Jousilahti P; Kajantie E; Kamat M; Karajamaki A; Karpe F; Koistinen HA; Kovesdy CP; Kuulasmaa K; Laatikainen T; Lannfelt L; Lee IT; Lee WJ; Linneberg A; Martin LW; Moitry M; Nadkarni G; Neville MJ; Palmer CNA; Papanicolaou GJ; Pedersen O; Peters J; Poulter N; Rasheed A; Rasmussen KL; Rayner NW; Magi R; Renstrom F; Rettig R; Rossouw J; Schreiner PJ; Sever PS; Sigurdsson EL; Skaaby T; Sun YV; Sundstrom J; Thorgeirsson G; Esko T; Trabetti E; Tsao PS; Tuomi T; Turner ST; Tzoulaki I; Vaartjes I; Vergnaud AC; Willer CJ; Wilson PWF; Witte DR; Yonova-Doing E; Zhang H; Aliya N; Almgren P; Amouyel P; Asselbergs FW; Barnes MR; Blakemore AI; Boehnke M; Bots ML; Bottinger EP; Buring JE; Chambers JC; Chen YDI; Chowdhury R; Conen D; Correa A; Smith GD; de Boer RA; Deary IJ; Dedoussis G; Deloukas P; Di Angelantonio E; Elliott P; Felix SB; Ferrieres J; Ford I; Fornage M; Franks PW; Franks S; Frossard P; Gambaro G; Gaunt TR; Groop L; Gudnason V; Harris TB; Hayward C; Hennig BJ; Herzig KH; Ingelsson E; Tuomilehto J; Jarvelin MR; Jukema JW; Kardia SLR; Kee F; Kooner JS; Kooperberg C; Launer LJ; Lind L; Loos RJF; Majumder AA; Laakso M; McCarthy MI; Melander O; Mohlke KL; Murray AD; Nordestgaard BG; Orho-Melander M; Packard CJ; Padmanabhan S; Palmas W; Polasek O; Porteous DJ; Prentice AM; Province MA; Relton CL; Rice K; Ridker PM; Rolandsson O; Rosendaal FR; Rotter JI; Rudan I; Salomaa V; Samani NJ; Sattar N; Sheu WHH; Smith BH; Soranzo N; Spector TD; Starr JM; Sebert S; Taylor KD; Lakka TA; Timpson NJ; Tobin MD; van der Harst P; van der Meer P; Ramachandran VS; Verweij N; Virtamo J; Volker U; Weir DR; Zeggini E; Charchar FJ; Wareham NJ; Langenberg C; Tomaszewski M; Butterworth AS; Caulfield MJ; Danesh J; Edwards TL; Holm H; Hung AM; Lindgren CM; Liu CY; Manning AK; Morris AP; Morrison AC; O'Donnell CJ; Psaty BM; Saleheen D; Stefansson K; Boerwinkle E; Chasman DI; Levy D; Newton-Cheh C; Munroe PB; Howson JMM
Contributors:	P. Surendran; E. Feofanova; N. Lahrouchi; I. Ntalla; S. Karthikeyan; J. Cook; L. Chen; B. Mifsud; C. Yao; A. Kraja; J. Cartwright; J. Hellwege; A. Giri; V. Tragante; G. Thorleifsson; D. Liu; B. Prin; I. Stewart; C. Cabrera; J. Eale; A. Akbarov; P. Auer; L. Bielak; J. Bi; V. Braithwaite; J. Brody; E. Daw; H. Warren; F. Dreno; S. Nielsen; J. Faul; E. Fauman; C. Fava; T. Ferreira; C. Foley; N. Franceschini; H. Gao; O. Giannakopoulou; F. Giulianini; D. Gudbjartsson; X. Guo; S. Harri; A. Havulinna; A. Helgadottir; J. Huffman; S. Hwang; S. Kanoni; J. Kontto; M. Larson; R. Li-Gao; J. Lindstrom; L. Lotta; Y. Lu; J. Luan; A. Mahajan; G. Malerba; N. Masca; H. Mei; C. Menni; D. Mook-Kanamori; D. Mosen-Ansorena; M. Muller-Nurasyid; G. Pare; D. Paul; M. Perola; A. Poveda; R. Rauramaa; M. Richard; T. Richardson; N. Sepulveda; X. Sim; A. Smith; J. Smith; J. Staley; A. Stanakova; P. Sulem; S. Theriault; U. Thorsteinsdottir; S. Trompet; T. Varga; D. Edward; G. Veronesi; S. Wei; S. Willem; J. Yao; R. Young; B. Yu; W. Zhang; J. Zhao; W. Zhao; E. Evangelou; S. Aeschbacher; E. Asllanaj; S. Blankenberg; L. Bonnycastle; J. Bork-Jensen; I. Brandslund; P. Braund; S. Burge
Publication Year:	2020
Collection:	The University of Milan: Archivio Istituzionale della Ricerca (AIR)
Subject Terms:	Settore MEDS-24/A - Statistica medica
Description:	Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to similar to 1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency
Document Type:	article in journal/newspaper
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/33230300; info:eu-repo/semantics/altIdentifier/wos/WOS:000592028900001; volume:52; issue:12; firstpage:1314; lastpage:1332; numberofpages:19; journal:NATURE GENETICS; https://hdl.handle.net/2434/1100331
Availability:	https://hdl.handle.net/2434/1100331
Rights:	info:eu-repo/semantics/openAccess
Accession Number:	edsbas.9E3A558E
Database:	BASE